Graphene–MoS2–metal hybrid structures for plasmonic biosensors

Abstract

Surface Plasmon Resonance (SPR) biosensors are widely used for real-time label-free detection in medical diagnostics, pharmaceutical researches and food safety. Although there is a growing interest in miniaturization of biosensors for selfdetection and diagnostics at out of laboratory, the performance of conventional metal SPR sensors is still limited. In this paper, we theoretically propose graphene-MoS 2-metal hybrid structures based plasmon sensors under the best minimum light intensity approach, which represents the performance analysis in case of the lowest reflected light strength. It is demonstrated that the metal thickness can be reduced from 55 nm to 32 nm and 37 nm meanwhile the performance of the background sensor can be improved by 87% and 13% with the 4 additional MoS 2 and graphene layers, respectively. Besides MoS 2 based SPR devices provide much better sensitivity performance than that of graphene, our results reveal the another promising property of MoS 2 , the sensitivity of SPR sensors can be greatly increased with a few number of MoS 2 within the angular SPR system while reducing the size of the device, especially for particular applications such as detecting a single molecule and biosensing at low biomolecule concentration. Furthermore, for the first time we show that the equivalent optical properties of a multilayered structure is also depend on the layer thickness which provide a novel knowledge for the next studies on 2D material based SPR plasmonic devices with the multilayered structures.

Graphene/MoS2 Nanohybrid for Biosensors

“…The graphene/MoS 2 nanohybrid has also been used to develop surface plasmon resonance (SPR) biosensors and SERS biosensors [ 156 , 157 , 158 ]. For example, an optical fiber-based SPR biosensor composed of Ag, MoS 2 , and a graphene nanohybrid was developed to sense DNA hybridization through computational modeling [ 159 ].…”

Ultrasensitive Field‐Effect Biosensors Enabled by the Unique Electronic Properties of Graphene

“…Similarly, the tunnel barrier for graphene spintronics can also be realized by CVD h‐BN, placed over the graphene and used either as a monolayer or bilayer . Moreover, graphene–MoS 2 –metal hybrid structures can be used as ultrasensitive plasmonic biosensor . MoS 2 as well as other 2D materials by themselves provide additional possibility for noncovalent functionalization as routes toward novel field‐effect‐based biosensors …”

Tuning and Sensitivity Improvement of Bi-Metallic Structure-Based Surface Plasmon Resonance Biosensor with 2-D $$\upvarepsilon$$-Tin Selenide Nanosheets

“…In particular, graphene has attractive properties such as tunable electrical and optical characteristics [ 27 ], ring-type carbon structure and high surface-to-volume ratio. Thus, the adsorbates can easily interact with this structure, increasing the adsorption ability of the biosensors [ 28 , 29 ].…”