Graphene materials: Armor against nosocomial infections and biofilm formation – A review

Dey, Nibedita; Vickram, A.S.; Thanigaivel, S.; Kamatchi, C.; Subbaiya, Ramasamy

doi:10.1016/j.envres.2022.113867

Cited by 31 publications

(10 citation statements)

References 95 publications

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“…Compared with traditional antibacterial agents, antibiofilm nanoagents provide superior biocompatibility, multifunctionalization, active and passive targeting capabilities, high drug-loading ability, and the ability to protect the biological activity of antibacterial drugs. [134,135] However, in the context of biofilm treatment, on account of the biofilm matrix barrier, these antibiofilm nanoagents are generally enriched on the biofilm surface, with poor biofilm permeability; [136] thus, the bacteria encased in the biofilm matrix are often not removed, causing recurrent infections. [24] Therefore, antibiofilm nanoagents must overcome the biofilm matrix.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Wang

Mei

et al. 2022

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Bacterial biofilms cause persistent infectious diseases and create tremendous obstacles to anti-infection treatment. [5,6] Epidemiological evidence has shown that biofilm formation poses a risk of chronic infection for clinical treatments, particularly in implant patients [7,8] such as cardiovascular grafts, fracture treatment, and orthodontic treatment. [9,10] If the biofilm infection is not cured in time, the long-term use of antibiotics to treat chronic infection may further aggravate the negative impact of antibiotics on the human body.The particular structure and components of the biofilm hinder the penetration efficiency of drugs and reduce the therapeutic effect of antibiotics, causing the hazard of bacterial biofilms. [11] In addition, some drug-resistant bacteria that inhabit the biofilms could secrete hydrolases (e.g., β-lactamases) to degrade antibiotics, making antibiotics ineffective. [12] In biofilms, the matrix, which accounts for most of the dry mass, possesses diverse functions such as the external digestive system, recycling center, gene pool, and nutrient source. [13,14] Biofilm organisms produce extracellular polymeric substances (EPS), primarily comprising exopolysaccharides, proteins, lipids, and extracellular DNA (eDNA), varying according to the environmental conditions. [15,16] EPS protects the organism from drying, oxidization, charged biocides, antibiotics, metal cations, and the host's immune defenses. [13,17,18] Additionally, EPS limits the diffusion of nutrients, creating a nutrient-deficient environment, further resulting in the slow metabolism of bacteria within the biofilm, making the bacteria less sensitive to antibiotics. [19] First, obstruction of the biofilm matrix results in extremely poor antibiotic and nutrient permeability. The aggregation of cations, such as Ca 2+ and Mg 2+ , in biofilms, promotes crosslinking between polymeric polysaccharide molecules, increasing both the viscosity and binding forces of the biofilm matrix. [20] The hydrophilic-hydrophobic properties of EPS also influence the drug penetration effect, which is related to the hydration state of EPS. [21,22] Furthermore, EPS helps immobilize bacterioplankton. The embedded bacteria in the biofilm show intense interconnections and produce stronger intercellular signal communication, a process called quorum sensing (QS). [23] Benefitting from QS, a relatively Bacterial biofilm-related infectious diseases severely influence human health. Under typical situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are functional aggregates that coat bacteria with extracellular polymeric substances (EPS). The main reason for the failure of biofilm infection treatment is the low permeability and enrichment of therapeutic agents within the biofilm, which results from the particular features of biofilm matrix barriers such as negatively charged biofilm components and highly viscous compact EPS structures. Hence, developing novel therapeutic strategies with enhanced biofilm penetrability is...

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Wang

Mei

et al. 2022

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“…Nosocomial infections, which are often commonly referred to as healthcare-related illnesses, represent a significant task in medical facilities, causing increased mortality and morbidity among patients around the world. The root of this problem is microbial colonization and development on the surface of biomedical implants and equipment [ 24 ]. Numerous harmful bacterial strains have been commonly found inhabiting medical devices and surfaces, and they are easily spread to patients during routine medical procedures [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Aluminum oxide, cobalt aluminum oxide, and aluminum-doped zinc oxide nanoparticles as an effective antimicrobial agent against pathogens

Omeiri,

El Hadidi,

Awad

et al. 2024

Heliyon

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“…After working with graphene for several years, some applications have already been found, such as fuel cells and biological devices or anticorrosive coatings for metals. [ 10–14 ]…”

Section: Introductionmentioning

confidence: 99%

“…After working with graphene for several years, some applications have already been found, such as fuel cells and biological devices or anticorrosive coatings for metals. [10][11][12][13][14] Attempts have been made to use pure graphene coatings for corrosion protection, for example, by chemical vapor deposition (CVD), but this is associated with some difficulties. Although these coatings provide very good short-term protection, they can even have the opposite effect over the longer term.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a commercial graphene‐additive for boosting the corrosion performance of a thermal curing primer

Wiener

Strauß

Luckeneder

et al. 2023

Materials & Corrosion

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Graphene has emerged as a promising additive for improving the corrosion resistance of organic coatings due to its planar structure and low permeability. Multiple publications have reported positive results, primarily because of its barrier qualities. However, the incorporation of graphene into commercial coatings has not been studied in great detail, as the limited availability of commercial‐grade graphene has hindered its widespread use. This study investigates the addition of a commercially available graphene additive to a commercial primer, using industry‐standard corrosion tests and advanced characterization techniques to evaluate the coating's performance. The results show that while the addition does improve the barrier properties of the coating, as shown in salt spray tests, it also reduces its functionality due to factors such as oxygen reduction on graphene and accelerated diffusion pathways. Overall, the cost of incorporating graphene may outweigh the limited benefits observed in this study. These findings underscore the need for further research to explore the potential of graphene and the importance of utilizing multiple testing methods for performance evaluation.

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Graphene materials: Armor against nosocomial infections and biofilm formation – A review

Cited by 31 publications

References 95 publications

Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Aluminum oxide, cobalt aluminum oxide, and aluminum-doped zinc oxide nanoparticles as an effective antimicrobial agent against pathogens

Evaluation of a commercial graphene‐additive for boosting the corrosion performance of a thermal curing primer

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