Graphene/Cu Nanoparticle Hybrids Fabricated by Chemical Vapor Deposition As Surface-Enhanced Raman Scattering Substrate for Label-Free Detection of Adenosine

Xu, Shicai; Man, Baoyuan; Jiang, Shouzhen; Wang, Jihua; Wei, Jie; Xu, Shiguo; Liu, Hanping; Gao, Shoubao; Liu, Huilan; Li, Zhenhua; Li, Hongsheng; Qiu, Hengwei

doi:10.1021/acsami.5b02303

Cited by 157 publications

(68 citation statements)

References 72 publications

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“…Based on the SEM results shown in Figure S1b,f (Supporting Information), we observe that the density of the annealed AgNPs is relatively low compared to that of the chemical synthesized AgNPs and that the diameter of the former is larger than that of the latter. It has been shown by many groups that, although the large metal nanoparticles possess a high local electric field, the total enhancement cannot be comparable with that of small metal nanoparticles because of the lack of hot spots for the former . Moreover, another obvious and crucial difference for these AgNPs synthesized with different methods is the shape of the AgNPs.…”

Section: Resultsmentioning

confidence: 99%

“…Surface enhanced Raman scattering (SERS), since it was first demonstrated in 1974, has been widely studied regarding both its enhancement mechanism and enhanced properties . With the development of SERS over the past several decades, SERS substrates based on different materials, such as metal, semiconductor, and 2D material, have been designed. The various SERS substrates can be divided into two categories in terms of their surface structure: 2D and 3D substrates.…”

Section: Introductionmentioning

confidence: 99%

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Constructing 3D and Flexible Plasmonic Structure for High‐Performance SERS Application

et al. 2018

Adv Materials Technologies

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provide more hot spots, which are introduced by the electromagnetic mechanism (EM). By the virtue of their larger specific surface area and periodic structure, 3D SERS substrates can effectively amplify the optical field around metal nanoparticles (NPs), thereby enhancing the Raman signal. Moreover, the 3D structure of these substrates is beneficial for the enrichment of probe molecules around metal nanoparticles; as a result, one can still obtain a high Raman signal, even under an ultralow concentration. Consequently, an increasing number of researchers are now focusing on the design and fabrication of 3D SERS substrates.To make full use of the merits of the 3D structure, SERS substrates based on 2D materials and metal nanoparticles have been combined and proposed. [23,24] In these 3D SERS substrates, the 3D structure can fully utilize the 3D focal volume of the incident beam and increase the density of the metal nanoparticles. Furthermore, introduction of the 2D material can act as an atomically thick SERS substrate, [25] perfect absorbent layer of molecules, [26] excellent sub-nanometer spacer, [27] and passivation layer for metal, [28,29] and introduce enhancements via a chemical mechanism (CM). Previously, a 3D SERS substrate based on graphene covering a pyramid-shaped Au structure was reported to achieve high enhancement. [30] While the integration of graphene and pyramid-shaped Au was successfully implemented, this 3D SERS substrate was not flexible and did not meet with the requirements when detecting probe molecules on an arbitrary curvilinear surface.Therefore, transformation of these stiff 3D substrates into flexible structures via using various methods has been investigated extensively. Leem et al. reported 3D crumpled graphene-AuNPs hybrid structures for SERS applications using a mechanical self-assembly strategy on a thermally activated polymer. [31] Similarly, Lee et al. fabricated a rippled graphene structure on a polystyrene substrate using a thermal rippling process and demonstrated the increased plasmonic coupling and higher density of the hot spots on the rippled nanostructure. [32] Kumar et al. presented a flexible SERS sensor by depositing Ag on structured polydimethylsiloxane using a Taro leaf as the template and achieved highly sensitive detection for malachite green. [33] Moreover, to fabricate a flexible 3D SERS substrate, the transfer printing technique, [34] shadow Substrate design has attracted much interest in development of an effective surface enhanced Raman scattering (SERS) sensor. A flexible SERS substrate with excellent performance needs to be sensitive to details of the preparation process; this sensitivity represents a significant challenge for practical applications as opposed to laboratory research applications. Here, a 3D flexible plasmonic structure, AgNPs@MoS 2 /pyramidal polymer (polymethyl methacrylate), is fabricated using a simple and lowcost method. Using experiments and theoretical simulations, the SERS performance of the proposed substrate is assessed in terms of ...

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Constructing 3D and Flexible Plasmonic Structure for High‐Performance SERS Application

et al. 2018

Adv Materials Technologies

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“…Interestingly, we note that the enhancement factors are more pronounced at long wavelength. The maximum electric field intensity enhancement (| E | 2 /| E 0 | 2 ) created by monolayer MoS 2 for AuMAu and AgMAu reached up to ≈10 9 , which is much larger than previously reported metal nanostructures . Furthermore, both the AuMAu and AgMAu possessed the 3D bump structure and large amount of nanogaps among the assemblies, which is beneficial for adsorption of the analytes, therefore, making the analytes more accessible to the high density of hot spots.…”

Section: Resultsmentioning

confidence: 78%

3D Hybrid Plasmonic Nanostructures with Dense Hot Spots Using Monolayer MoS₂ as Sub‐Nanometer Spacer

Jiang

Huo

et al. 2018

Adv Materials Inter

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some problems for the use of graphene. First, it has been demonstrated that the intensity of the EF generally increase as the gap decreases from 10 nm to 6.2 Å but fall off dramatically when the gap further decrease from 6.2 Å for the occurrence of quantum mechanical effects based on the results of the simulation and experiments. [16] The thickness of monolayer graphene is just 3.4 Å, which is so thin that the quantum mechanical electron tunneling emerge in a NP/G/NP or NP/G/ metal film structure. For such nanostructures, the electron tunneling can reduce the accumulation of opposite charges on the both sides of gap and further the EF in the "hot spots" would decrease. Second, the graphene film would tear and suspend inevitably in the transferring process and cannot be covered tightly on the top of the nanostructure with many sharp irregular shapes. [17] To realize the better plasmonic couplings, a kind of new spacer with superior optical property and stability should be introduced. Molybdenum disulfide (MoS 2 ), a semiconductor crystal, has a hexagonal crystal structure with the Mo atom in a trigonal biprism coordination sandwiched between two S atom layers. The MoS 2 films have drawn a lot of attention for applications in energy conversion, photocatalysis, and biochemical sensing for its low cost, good chemical performance, and high stability. [18][19][20][21] Consequently, many researches have reported MoS 2 combined with plasmonic structures and showed excellent photoelectrical properties recently. [22][23][24] In this work, we proposed a 3D hybrid structure using mono layer MoS 2 as spacer between adjacent metal NP. The direct growth of MoS 2 films on AuNP was first realized and the monolayer MoS 2 /AuNP was further obtained after the simple ultrasonic treatment. The AuNP and AgNP were used separately as the third metal nanostructure through the metal films sputtering and annealing process on the surface of the MoS 2 /AuNP. Then, the AuNP/MoS 2 /AuNP (AuMAu) and AgNP/MoS 2 /AuNP (AgMAu) hybrid assemblies were all fabricated and investigated, respectively. Although the hybrid structure seems to have some structural similarities with some works using graphene as spacer, there are several differences. First, the thickness of monolayer MoS 2 is around 6.5 Å close to the optimum gap size (6.2 Å), which is supposed to obtain the considerable enhancement of the EF. The monolayer MoS 2 can act as an insulating sub-nanometer spacer between two metal NP layers for its high vertical resistance and gap thickness to effectively prevent the emergence of the quantum Here, 3D hybrid plasmonic nanostructures using monolayer MoS 2 as subnanometer spacer with high density hot spots are fabricated. For the 3D hybrid assemblies, the hot spots exist not only on the 0.65 nm thick MoS 2 gap regions between large and small nanoparticles (NP) but also between small and small NP. The high-density hot spots induce prominently enhanced optical absorption, huge surface enhanced Raman scattering effect, excellent reproducibility, and ultr...

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“…However, efficiency as well as sensitivity of SERS is limited [7]. Raman effect can be remarkably enhanced if metal nanoparticles like silver, gold and copper have been adsorbed upon by the molecule or are in immediate vicinity [8,9]. Localized surface plasmon resonance as well as charge transfer enhances SERS signal within the range of 10 3 −10 6 .…”

Section: Introductionmentioning

confidence: 99%

Gold and silver nanoparticles used for SERS detection of S. aureus and E. coli

Ankamwar

Gharpure

2020

Nano Ex.

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Surface enhanced Raman scattering (SERS) is emerging as a robust analytical method used in sensing applications in chemical as well as biological systems. SERS has been reported to be used in fast detection of micro-organisms up to the specificity of strain identification. However, use of SERS is tricky because of difficulties involved in selection of SERS active substrate so as to give uniform, sensitive as well as reproducible results. We have synthesized silver and gold nanoparticles using chemical, electrochemical and microwave-assisted methods followed by their characterization. Uses of these nanoparticles in association with micro-organisms such as S. aureus and E. coli have been analyzed using SERS to generate signature spectra. This demonstrates use of so synthesized gold and silver nanoparticles as SERS active substrates for rapid detection of micro-organisms which pave way to find applications in disease diagnostics.

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Graphene/Cu Nanoparticle Hybrids Fabricated by Chemical Vapor Deposition As Surface-Enhanced Raman Scattering Substrate for Label-Free Detection of Adenosine

Cited by 157 publications

References 72 publications

Constructing 3D and Flexible Plasmonic Structure for High‐Performance SERS Application

Constructing 3D and Flexible Plasmonic Structure for High‐Performance SERS Application

3D Hybrid Plasmonic Nanostructures with Dense Hot Spots Using Monolayer MoS₂ as Sub‐Nanometer Spacer

Gold and silver nanoparticles used for SERS detection of S. aureus and E. coli

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Graphene/Cu Nanoparticle Hybrids Fabricated by Chemical Vapor Deposition As Surface-Enhanced Raman Scattering Substrate for Label-Free Detection of Adenosine

Cited by 157 publications

References 72 publications

Constructing 3D and Flexible Plasmonic Structure for High‐Performance SERS Application

Constructing 3D and Flexible Plasmonic Structure for High‐Performance SERS Application

3D Hybrid Plasmonic Nanostructures with Dense Hot Spots Using Monolayer MoS2 as Sub‐Nanometer Spacer

Gold and silver nanoparticles used for SERS detection of S. aureus and E. coli

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3D Hybrid Plasmonic Nanostructures with Dense Hot Spots Using Monolayer MoS₂ as Sub‐Nanometer Spacer