Graphene, carbon nanotubes, zinc oxide and gold as elite nanomaterials for fabrication of biosensors for healthcare

Kumar, Sandeep; Ahlawat, Wandit; Kumar, Rajesh; Dilbaghi, Neeraj

doi:10.1016/j.bios.2015.03.062

Cited by 344 publications

(173 citation statements)

References 34 publications

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“…For example, enzymatic biosensors face serious problems of inactivation or loss which affect sensing performance [20,21]. Hence, enzymes immobilization emerges as a key technology that enables practical and commercial viability of such biocatalysts [19,20,22].…”

Section: Nanoparticle Surface Immobilization Of Proteins and Enzymesmentioning

confidence: 99%

“…In addition, nanotoxicity concerns need to be addressed when aiming for applications involving biological cells, tissues, or animal models [153,154]. Finally, commercial viability of protein-carbon nanoparticle systems requires cost-effective synthesis and manufacturing, and competitiveness with regard to other commercially available products [21,154].…”

Section: Challengesmentioning

confidence: 99%

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Protein functionalized carbon nanomaterials for biomedical applications

Oliveira

Bisker

Bakh

et al. 2015

Carbon

185

111

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a b s t r a c tSince the discovery of low-dimensional carbon allotropes, there is increasing interest in using carbon nanomaterials for biomedical applications. Carbon nanomaterials have been utilized in the biomedical field for bioimaging, chemical sensing, targeting, delivery, therapeutics, catalysis, and energy harvesting. Each application requires tailored surface functionalization in order to take advantage of a desired property of the nanoparticles. Herein, we review the surface immobilization of bio-molecules, including proteins, peptides, and enzymes, and present the recent advances in synthesis and applications of these conjugates. The carbon scaffold and the biological moiety form a complex interface which presents a challenge for achieving efficient and robust binding while preserving biological activity. Moreover, some applications require the utilization of the protein-nanocarbon system in a complex environment that may hinder its performance or activity. We analyze different strategies to overcome these challenges when using carbon nanomaterials as protein carriers, explore various immobilization techniques along with characterization methods, and present recent demonstrations of employing these systems for biomedical applications. Finally, we consider the challenges and future directions of this field.

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Section: Nanoparticle Surface Immobilization Of Proteins and Enzymesmentioning

confidence: 99%

Section: Challengesmentioning

confidence: 99%

Protein functionalized carbon nanomaterials for biomedical applications

Oliveira

Bisker

Bakh

et al. 2015

Carbon

185

111

View full text Add to dashboard Cite

show abstract

“…[14] More importantly, compared with pure CNT films, GOCNT composite films with both hydrophobic and hydrophilic groups offer much better compatibility in both organic solvents and water, with dramatically enhanced mechanical properties providing great advantages in solution-based processing. [15,16] Photovoltaics based on the heterojunction created between silicon (Si) and GOCNT hybrid film, GOCNT/Si, have been studied extensively. [14] In such a device, as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Application of Hole-Transporting Materials as the Interlayer in Graphene Oxide/Single-Wall Carbon Nanotube Silicon Heterojunction Solar Cells

Grace

Pham

et al. 2017

Aust. J. Chem.

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Solid-state hole-transporting materials, including the traditional poly (3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), and recently developed 4,4 0 -(naphthalene-2,6-diyl)bis(N,N-bis(4-methoxyphenyl)aniline) (NAP) and (E)-4 0 ,4, have been applied as a hole-transporting interlayer (HTL) for graphene oxide/single-walled carbon nanotube-silicon (GOCNT/Si) heterojunction solar cells, forming a GOCNT/HTL/Si architecture. The influence of the thickness of the HTL has been studied. A new AuCl 3 doping process based on bath immersion has been developed and proved to improve the efficiency. With the AuCl 3 -doped GOCNT electrodes, the efficiency of GOCNT/PEDOT:PSS/Si, GOCNT/NAP/Si, and GOCNT/BPV/Si devices was improved to 12.05 AE 0.21, 10.57 AE 0.37, and 10.68 AE 0.27 % respectively. This study reveals that the addition of an HTL is able to dramatically minimise recombination at the heterojunction interface.

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“…Biosensing is a scientific and technological hot topic, given its potential in the field of medical diagnosis [1], healthcare [2], environment [3], defense [4], and food security [5].…”

Section: Introductionmentioning

confidence: 99%

Bioengineered Surfaces for Real-Time Label-Free Detection of Cancer Cells

Martucci¹,

Migliaccio²,

ImmacolataRuggiero³

et al. 2016

Lab-on-a-Chip Fabrication and Application

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Biosensing technology is an advancing field that benefits from the properties of biological processes combined to functional materials. Recently, biosensors have emerged as essential tools in biomedical applications, offering advantages over conventional clinical techniques for diagnosis and therapy. Optical biosensors provide fast, selective, direct, and cost-effective analyses allowing label-free and real-time tests. They have also shown exceptional potential for integration in lab-on-a-chip (LOC) devices. The major challenge in the biosensor field is to achieve a fully operative LOC platform that can be used in any place at any time. The choice of an appropriate strategy to immobilize the biological element on the sensor surface becomes the key factor to obtain an applicable analytical tool. In this chapter, after a brief description of the main biofunctionalization procedures on silicon devices, two silicon-based chips that present an (i) IgG antibody or (ii) an Id-peptide as molecular probe, directed against the B-cell receptor of lymphoma cancer cells, will be presented. From a comparison in detecting cells, the Id-peptide device was able to detect lymphoma cells also at low cell concentrations (8.5 × 10 −3 cells/μm 2 ) and in the presence of a large amount of non-specific cells. This recognition strategy could represent a proof-of-concept for an innovative tool for the targeting of patient-specific neoplastic B cells during the minimal residual disease; in addition, it represents an encouraging starting point for the construction of a lab-on-a-chip system for the specific recognition of neoplastic cells in biological fluids enabling the follow-up of the changes of cancer cells number in patients, highly demanded for therapy monitoring applications.

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Graphene, carbon nanotubes, zinc oxide and gold as elite nanomaterials for fabrication of biosensors for healthcare

Cited by 344 publications

References 34 publications

Protein functionalized carbon nanomaterials for biomedical applications

Protein functionalized carbon nanomaterials for biomedical applications

Application of Hole-Transporting Materials as the Interlayer in Graphene Oxide/Single-Wall Carbon Nanotube Silicon Heterojunction Solar Cells

Bioengineered Surfaces for Real-Time Label-Free Detection of Cancer Cells

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