Graphene Can Wreak Havoc with Cell Membranes

Dallavalle, Marco; Calvaresi, Matteo; Bottoni, Andreà; Melle‐Franco, Manuel; Zerbetto, Francesco

doi:10.1021/am508938u

Cited by 149 publications

(144 citation statements)

References 68 publications

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“…An additional mechanical effect was reported by Liu et al, who suggested a size-dependent wrapping of bacteria by graphene oxide sheets that resulted in higher antibacterial activity for larger sheets [36,37]. Using dissipative particle dynamics simulations, Dallavalle and co-authors studied the various potential interactions of graphene with lipid bilayers and emphasized the resulting adverse effects for cell membranes [38]. …”

Section: Inherent Antibacterial Properties Of Carbon Nanomaterialsmentioning

confidence: 99%

Carbon Nanomaterials as Antibacterial Colloids

Maas

2016

Materials

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Carbon nanomaterials like graphene, carbon nanotubes, fullerenes and the various forms of diamond have attracted great attention for their vast potential regarding applications in electrical engineering and as biomaterials. The study of the antibacterial properties of carbon nanomaterials provides fundamental information on the possible toxicity and environmental impact of these materials. Furthermore, as a result of the increasing prevalence of resistant bacteria strains, the development of novel antibacterial materials is of great importance. This article reviews current research efforts on characterizing the antibacterial activity of carbon nanomaterials from the perspective of colloid and interface science. Building on these fundamental findings, recent functionalization strategies for enhancing the antibacterial effect of carbon nanomaterials are described. The review concludes with a comprehensive outlook that summarizes the most important discoveries and trends regarding antibacterial carbon nanomaterials.

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Section: Inherent Antibacterial Properties Of Carbon Nanomaterialsmentioning

confidence: 99%

Carbon Nanomaterials as Antibacterial Colloids

Maas

2016

Materials

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“…The destruction of bacteria membrane stems from graphene induced oxidative stress has been reported by other research communities2728. Moreover, experimental and theoretical study show that strong dispersion interaction between graphene and phospholipids eventually lead to the membrane degradation by robust extraction of phospholipids2930. Meanwhile, with the advantage of presence of dirac point, graphene can be assumed as a semimetal, and it would lead to the forming of Schottky barrier at the interface when contact with a semiconductor2021.…”

Section: Discussionmentioning

confidence: 85%

“…Electrostatic interaction between positively charged pristine graphene and negatively charged bacterial membrane makes the phospholipids band together with graphene films. Meanwhile, the contact might induce translocation and overturn of phospholipids and make phospholipids interact with hydrophobic tail due to hydrophobic interaction, which further disrupt the function of the membrane30. Therefore, the bacteria death caused by membrane rupture would be very likely to occur, since the translocation of phospholipids is inclined to destroy the structure of bacterial membrane.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial ability and hemocompatibility of graphene functionalized germanium

Geng¹,

Dai²,

Li³

et al. 2016

Sci Rep

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Germanium (Ge), as an elemental semiconductor material, has been an attractive candidate for manufacturing semiconductor microelectronic device. In the present investigation, to improve the biocompatibility of Ge-based device, graphene film is directly deposited on the Ge surface with different coverage area by controlling the growth time. Compared to bare Ge, the presence of graphene film entitles Ge with satisfactory antibacterial ability against Staphylococcus aureus (S.aureus), and acceptable antibacterial ability against Escherichia coli (E. coli). Meanwhile, antibacterial efficiency closely correlates with coverage area of graphene film, and larger graphene coverage always leads to better antibacterial performance. The underlying mechanism is thought to be the integrative action of phospholipids disturbance and electron extraction at the interface between graphene and biomembrane. Meanwhile, the electron extraction action would further lead to the activation of platelet. This study might provide some new insights into the relationship between antibacterial ability and hemocompatibility based on graphene functionalized biomedical device.

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“…Because of their mechanical stability, well-understood surface chemistry, and excellent optical and thermal properties, they are extensively studied for use in nanotechnology and are promising for a wide range of biomedical applications such as gene delivery, cellular imaging, and tumor therapy [17]. Many theoretical, experimental, and computational studies have explored the interaction of graphene sheets with cell membranes and proteins[18] [19] [20] [21] [22] [23] [24–26] [27, 28]. The molecular mechanism behind the antibacterial activity of graphene sheets on Escherichia coli was investigated with molecular dynamics (MD) simulations and experiments.…”

Section: Introductionmentioning

confidence: 99%

Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments

Jeevan

Pokhrel

Bhattarai

et al. 2017

Biochemical and Biophysical Research Communications

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Ebola virus infections cause hemorrhagic fever that often results in very high fatality rates. In addition to exploring vaccines, development of drugs is also essential for treating the disease and preventing the spread of the infection. The Ebola virus matrix protein VP40 exists in various conformational and oligomeric forms and is a potential pharmacological target for disrupting the virus life-cycle. Here we explored graphene-VP40 interactions using molecular dynamics simulations and graphene pelleting assays. We found that graphene sheets associate strongly with VP40 at various interfaces. We also found that the graphene is able to disrupt the C-terminal domain (CTD-CTD) interface of VP40 hexamers. This VP40 hexamer-hexamer interface is crucial in forming the Ebola viral matrix and disruption of this interface may provide a method to use graphene or similar nanoparticle based solutions as a disinfectant that can significantly reduce the spread of the disease and prevent an Ebola epidemic.

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Graphene Can Wreak Havoc with Cell Membranes

Cited by 149 publications

References 68 publications

Carbon Nanomaterials as Antibacterial Colloids

Carbon Nanomaterials as Antibacterial Colloids

Antibacterial ability and hemocompatibility of graphene functionalized germanium

Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments

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