Graphene blended with SnO 2 and Pd-Pt nanocages for sensitive non-enzymatic electrochemical detection of H 2 O 2 released from living cells

Fu, Yiming; Huang, Di; Li, Congming; Zou, Lina; Ye, Baoxian

doi:10.1016/j.aca.2018.01.067

Cited by 75 publications

(29 citation statements)

References 51 publications

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“…Table 1 also compares the response of non‐enzymatic hydrogen peroxide sensors based on other hybrid materials. Among them, our sensor presents a very competitive performance with lower detection limit than most of them [36–38, 42–44, 48, 56–58], comparable to [39, 40, 45, 46, 50–52] and higher than [15, 41, 47, 53–55]. In general, the sensors that present better detection limits than our sensor, are built with several constituents that can make the preparation of the sensor more time consuming, like MWCNTs dispersed in avidin and Ru [15], GO, Fe 3 O 4 , PAMAM and Pd [41], Ag@Cu 2 O and N‐rGO [47], Pt nanoparticles and polyazure A [53], three‐dimensional CuO inverse opals coated with NiO nanoflowers [54] or Au and Ag nanoparticles in connection with a potential of −0.700 V [55].…”

Section: Resultsmentioning

confidence: 99%

MWCNT‐Organoimido Polyoxomolybdate Hybrid Material: Analytical Applications for Amperometric Sensing of Hydrogen Peroxide

et al. 2021

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We report a hybrid material obtained by dispersing the polyoxometalate n‐[Bu4‐N]2[Mo6O18NC13H9] functionalized with 2‐aminofluorene (POMAF) and multi‐walled carbon nanotubes (MWCNTs) in 1,3‐dioxolane (MWCNT‐ POMAF). We demonstrate the peroxidase‐like activity of the hybrid material and its application for the amperometric quantification of hydrogen peroxide at −0.450 V previous drop‐coating at glassy carbon electrodes, with a linear range between 1.0 μM and 6.0 μM and a detection limit of 330 nM. The reproducibility was 2.2 % using one MWCNTs‐POMAF dispersion, and 3.9 % using 4 different dispersions. The sensor was successfully used for the quantification of hydrogen peroxide in enriched milk samples.

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Section: Resultsmentioning

confidence: 99%

MWCNT‐Organoimido Polyoxomolybdate Hybrid Material: Analytical Applications for Amperometric Sensing of Hydrogen Peroxide

et al. 2021

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“…In addition, to the best of our knowledge, this is the first time that H 2 O 2 is measured and quantified in the 6-OHDA model for Parkinson's disease using electrochemical sensors. Pd/Au NWs -50 vs Ag|AgCl, 3M KCl 3.0x10 -7 1.0x10 -6 -1.0x10 -3 HL-1 cells [47] PtPb/Graphene -200 vs Ag|AgCl 2.0x10 -9 2.0x10 -9 -2.5x10 -3 Raw 264.7 cells [48] CuO@MnAl LDHs -850 vs SCE 1.3x10 -7 6.0x10 -6 -22x10 -3 Epithelial normal cells HBL100, breast cancer cells MCF-7 and glioma brain cancer cells U87 [49] PdPt NCs@SGN/GCE -0.1 vs SCE 3.0x10 -7 3.0x10 -6 -3.0x10 -4 Hela cells [50] Ag NSs/GCE -500 vs Ag|AgCl, sat KCl 1.7x10 -7 5.0x10 -6 -6.0x10 -3 HeLa cells and SH-SY5Y cells [51] SPE-CB-PB-Nafion -50 mV vs Ag 1.0x10 -8 2.0x10 -7 -1.0x10 -3 Neuroblastoma SH-SY5Y cell line This work…”

Section: Application To H 2 O 2 Sensing In Shsy5y Differentiated In Nmentioning

confidence: 99%

Electrodeposited Prussian Blue on carbon black modified disposable electrodes for direct enzyme-free H2O2 sensing in a Parkinson’s disease in vitro model

Rojas

Pelle

Carlo

et al. 2018

Sensors and Actuators B: Chemical

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In this work, we present the combination of Carbon Black (CB) and electrodeposited Prussian Blue (PB) covered with a Nafion layer on Screen-Printed electrodes (CB/PB-SPE) used for non-enzymatic H 2 O 2 sensing in Neuroblastoma cell line SH-SY5Y. These cells were challenged with 6hidroxidopamine (6-OHDA) for modelling Parkinson's disease. The electrodes surface was investigated using Scanning Electron Microscopy (SEM) and electrochemically characterized, in terms of electroactivity and stability. Electrochemical sensing of H 2 O 2 was carried out at very low potentials (-50mV), with a LOD of 0.01 μM and linear range between 0.2 and 1000 μM, allowing interference-free detection of H 2 O 2 in the selected cell culture. The H 2 O 2 concentration was successfully monitored in an experimental model of Parkinson's disease. These results pave the way to a method for the continuous monitoring of H 2 O 2 in culture medium for future studies of the role of H 2 O 2 in Parkinson's disease.

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“…Overproduction of H 2 O 2 (>1 × 10 −3 m ) might associate with a variety of diseases such as cell damage that can even lead to senescence, neurodegeneration, and cancer . Therefore, detection of H 2 O 2 could offer direct indications of health states or disease progresses . In addition, many biomolecules such as glucose or uric acid have been indirectly detected by applying specific enzymes to catalyze the generation of H 2 O 2 by‐products, which allows conversion of the H 2 O 2 detection into the sensing of corresponding biomolecules .…”

Section: Introductionmentioning

confidence: 99%

Reduced Graphene Oxide Nanohybrid–Assembled Microneedles as Mini‐Invasive Electrodes for Real‐Time Transdermal Biosensing

Jin

Chen

et al. 2019

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A variety of nanomaterial‐based biosensors have been developed to sensitively detect biomolecules in vitro, yet limited success has been achieved in real‐time sensing in vivo. The application of microneedles (MN) may offer a solution for painless and minimally‐invasive transdermal biosensing. However, integration of nanostructural materials on microneedle surface as transdermal electrodes remains challenging in applications. Here, a transdermal H2O2 electrochemical biosensor based on MNs integrated with nanohybrid consisting of reduced graphene oxide and Pt nanoparticles (Pt/rGO) is developed. The Pt/rGO significantly improves the detection sensitivity of the MN electrode, while the MNs are utilized as a painless transdermal tool to access the in vivo environment. The Pt/rGO nanostructures are protected by a water‐soluble polymer layer to avoid mechanical destruction during the MN skin insertion process. The polymer layer can readily be dissolved by the interstitial fluid and exposes the Pt/rGO on MNs for biosensing in vivo. The applications of the Pt/rGO‐integrated MNs for in situ and real‐time sensing of H2O2 in vivo are demonstrated both on pigskin and living mice. This work offers a unique real‐time transdermal biosensing system, which is a promising tool for sensing in vivo with high sensitivity but in a minimally‐invasive manner.

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Graphene blended with SnO 2 and Pd-Pt nanocages for sensitive non-enzymatic electrochemical detection of H 2 O 2 released from living cells

Cited by 75 publications

References 51 publications

MWCNT‐Organoimido Polyoxomolybdate Hybrid Material: Analytical Applications for Amperometric Sensing of Hydrogen Peroxide

MWCNT‐Organoimido Polyoxomolybdate Hybrid Material: Analytical Applications for Amperometric Sensing of Hydrogen Peroxide

Electrodeposited Prussian Blue on carbon black modified disposable electrodes for direct enzyme-free H2O2 sensing in a Parkinson’s disease in vitro model

Reduced Graphene Oxide Nanohybrid–Assembled Microneedles as Mini‐Invasive Electrodes for Real‐Time Transdermal Biosensing

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