Graphene Biodevices for Early Disease Diagnosis Based on Biomarker Detection

Han, Qingfang; Pang, Jinbo; Li, Yufen; Sun, Bao‐Jun; Ibarlucea, Bergoi; Liu, Xiaoyan; Gemming, Thomas; Cheng, Qilin; Zhang, Shu; Liu, Hong; Wang, Jingang; Zhou, Weijia; Cuniberti, Gianaurelio; Rümmeli, Mark H.

doi:10.1021/acssensors.1c01172

Cited by 57 publications

(43 citation statements)

References 441 publications

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“…The variation in the parameters of peak current (I p ) and peak potential (E p ) are the main tools utilized as a means to calculate the TAC value of antioxidants. It is used for determining the antioxidant activity of food, polyphenolic compounds [ 50 ], clinical samples [ 51 ], and pathological processes and infectious diseases [ 52 , 53 ].…”

Section: Electrochemical Methodologiesmentioning

confidence: 99%

Electrochemical Methodologies for Investigating the Antioxidant Potential of Plant and Fruit Extracts: A Review

et al. 2022

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In recent years, the growing research interests in the applications of plant and fruit extracts (synthetic/stabilization materials for the nanomaterials, medicinal applications, functional foods, and nutraceuticals) have led to the development of new analytical techniques to be utilized for identifying numerous properties of these extracts. One of the main properties essential for the applicability of these plant extracts is the antioxidant capacity (AOC) that is conventionally determined by spectrophotometric techniques. Nowadays, electrochemical methodologies are emerging as alternative tools for quantifying this particular property of the extract. These methodologies address numerous drawbacks of the conventional spectroscopic approach, such as the utilization of expensive and hazardous solvents, extensive sample pre-treatment requirements, long reaction times, low sensitivity, etc. The electrochemical methodologies discussed in this review include cyclic voltammetry (CV), square wave voltammetry (SWV), differential pulse voltammetry (DPV), and chronoamperometry (CAP). This review presents a critical comparison between both the conventional and electrochemical approaches for the quantification of the parameter of AOC and discusses the numerous applications of the obtained bioextracts based on the AOC parameter.

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Section: Electrochemical Methodologiesmentioning

confidence: 99%

Electrochemical Methodologies for Investigating the Antioxidant Potential of Plant and Fruit Extracts: A Review

et al. 2022

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“…Graphene is one of the most studied CNMs for a variety of biosensing devices ( Figure 7 ) thanks to its exceptional electronic and mechanical properties, as recently reviewed in detail elsewhere [ 368 ]. Other less studied CNMs, such as CNOs, can also make attractive electrode components for the development of low-cost, simple to use, and highly sensitive sensors [ 237 , 369 ].…”

Section: Applications Of Cnm-enzyme Conjugatesmentioning

confidence: 99%

“… Graphene is one of the most popular CNMs, employed in a variety of biosensing devices thanks to its exceptional electronic and mechanical properties. Reproduced with permission from [ 368 ], Copyright © 2022 American Chemical Society. …”

Section: Figurementioning

confidence: 99%

Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation

et al. 2022

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Carbon nanomaterials (CNMs) and enzymes differ significantly in terms of their physico-chemical properties—their handling and characterization require very different specialized skills. Therefore, their combination is not trivial. Numerous studies exist at the interface between these two components—especially in the area of sensing—but also involving biofuel cells, biocatalysis, and even biomedical applications including innovative therapeutic approaches and theranostics. Finally, enzymes that are capable of biodegrading CNMs have been identified, and they may play an important role in controlling the environmental fate of these structures after their use. CNMs’ widespread use has created more and more opportunities for their entry into the environment, and thus it becomes increasingly important to understand how to biodegrade them. In this concise review, we will cover the progress made in the last five years on this exciting topic, focusing on the applications, and concluding with future perspectives on research combining carbon nanomaterials and enzymes.

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“…Indeed, drug-resistant cells, circulating tumor cells, and other cancer cells may all be detected using graphene sensors. According to their varying affinities, seven distinct types of molecules may be fixed onto the graphene surface to serve as probes for differentiating different cell types [ 45 ]. This sensor array makes contact with different cell surfaces, and a corresponding high-affinity probe seizes the target cells.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive TiO2/Au/Graphene Layer-Based Surface Plasmon Resonance Biosensor for Cancer Detection

et al. 2022

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In this article, a hybrid TiO2/Au/graphene layer-based surface plasmon resonance (SPR) sensor with improved sensitivity and capability for cancer detection is presented. The finite element method (FEM) was used for numerical analysis. The proposed SPR biosensor was structured based on the angular analysis of the attenuated total reflection (ATR) method for the detection of various types of cancer using the refractive index component. The resonance angle shifted owing to the increment of normal and cancerous cells’ refractive index, which varied between 1.36 and 1.401 for six different types of normal and cancerous cells. According to numerical results, the obtained sensitivities for skin (basal), cervical (HeLa), adrenal gland (PC12), blood (Jurkat), and breast (MCF-7 and MDA-MB-231) cancer cells were 210 deg/RIU, 245.83 deg/RIU, 264.285 deg/RIU, 285.71 deg/RIU, 292.86 deg/RIU, and 278.57 deg/RIU, respectively. Furthermore, the detection accuracy (DA), figure of merits (FOM), and signal-to-noise ratio (SNR) were also obtained, with values of 0.263 deg−1, 48.02 RIU−1, and 3.84, respectively. Additionally, the distribution of the electric field and the propagation of the magnetic field for resonant and non-resonant conditions of the proposed structure were illustrated. It was found that an enhanced field was exhibited on the surface of the plasmonic material for resonant conditions. We also measured the penetration depth of 180 nm using decayed electric field intensity. Furthermore, the impact of using a TiO2/Au/graphene layer was demonstrated. We further conducted analyses of the effects of the thickness of the gold layer and the effects of additional graphene layers on overall sensitivities for six different types of cancer. The proposed TiO2/Au/graphene layered structure exhibited the highest overall sensitivity in terms of detecting cancerous cells from healthy cells. Moreover, the proposed sensor was numerically analyzed for a wide range of biological solutions (refractive index 1.33 –1.41), and the sensor linearity was calculated with a linear regression coefficient (R2) of 0.9858. Finally, numerical results obtained in this manuscript exhibited high sensitivity in comparison with previously reported studies.

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Graphene Biodevices for Early Disease Diagnosis Based on Biomarker Detection

Cited by 57 publications

References 441 publications

Electrochemical Methodologies for Investigating the Antioxidant Potential of Plant and Fruit Extracts: A Review

Electrochemical Methodologies for Investigating the Antioxidant Potential of Plant and Fruit Extracts: A Review

Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation

Highly Sensitive TiO2/Au/Graphene Layer-Based Surface Plasmon Resonance Biosensor for Cancer Detection

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