Graphene-based sensing of oxygen transport through pulmonary membranes

Kim, Mijung; Porras-Gómez, Marilyn; Leal, Cecília

doi:10.1038/s41467-020-14825-9

Cited by 18 publications

(9 citation statements)

References 68 publications

(86 reference statements)

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“…In nature, lipid membranes: (i) structurally compartmentalize cellular components, (ii) stabilize membrane proteins, and (iii) select the transport of particular molecules or ions. Inspired by these functionalities, many scientists have developed lipid vesicular forms that enclose membranes in aqueous solution for a variety of biomedical applications such as drug/gene delivery, , artificial cell development, biosensors, − and the most recent mRNA–lipid vaccines. − Analogous polymer vesicles or polymersomes, − erupted thereafter given the similarity that amphiphilic copolymers have to self-assemble into numerous mesophases like micelles, vesicles, and tubes. , Even though the assembled structures are similar in form, lipid and polymer membranes have noticeably different properties such as bending and stretching moduli, lateral diffusivity, and permeability. Compared to lipids, polymers with typical molecular weights above 1 kDa are mechanically more robust and chemically versatile.…”

Section: Introductionmentioning

confidence: 99%

Polymer–Lipid Hybrid Materials

Leal

2021

Chem. Rev.

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Hierarchic self-assembly underpins much of the form and function seen in synthetic or biological soft materials. Lipids are paramount examples, building themselves in nature or synthetically in a variety of meso/nanostructures. Synthetic block copolymers capture many of lipid's structural and functional properties. Lipids are typically biocompatible and high molecular weight polymers are mechanically robust and chemically versatile. The development of new materials for applications like controlled drug/gene/protein delivery, biosensors, and artificial cells often requires the combination of lipids and polymers. The emergent composite material, a "polymer−lipid hybrid membrane", displays synergistic properties not seen in pure components. Specific examples include the observation that hybrid membranes undergo lateral phase separation that can correlate in registry across multiple layers into a three-dimensional phase-separated system with enhanced permeability of encapsulated drugs. It is timely to underpin these emergent properties in several categories of hybrid systems ranging from colloidal suspensions to supported hybrid films. In this review, we discuss the form and function of a vast number of polymer−lipid hybrid systems published to date. We rationalize the results to raise new fundamental understanding of hybrid self-assembling soft materials as well as to enable the design of new supramolecular systems and applications.

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Section: Introductionmentioning

confidence: 99%

Polymer–Lipid Hybrid Materials

Leal

2021

Chem. Rev.

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“…Oxygen can also be detected using several bulk instruments, such as AFM and x-rays to obtain fast results in a limited time. Researchers have used graphane, self-chargeable nano-bio-supercapacitors with microelectronic circuits, to sense oxygen and blood plasma (Kim et al (2020); Lee et al (2021)). However, these techniques are limited to rapid PoC applications.…”

Section: Selection Of Nanomaterialsmentioning

confidence: 99%

Towards Real-Time Oxygen Sensing: From Nanomaterials to Plasma

Vinitha

Chinmaya

CV³

et al. 2022

Front. Sens.

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A significantly large scope is available for the scientific and engineering developments of high-throughput ultra-high sensitive oxygen sensors. We give a perspective of oxygen sensing for two physical states of matters—solid-state nanomaterials and plasma. From single-molecule experiments to material selection, we reviewed various aspects of sensing, such as capacitance, photophysics, electron mobility, response time, and a yearly progress. Towards miniaturization, we have highlighted the benefit of lab-on-chip-based devices and showed exemplary measurements of fast real-time oxygen sensing. From the physical–chemistry perspective, plasma holds a strong potential in the application of oxygen sensing. We investigated the current state-of-the-art of electron density, temperature, and design issues of plasma systems. We also show numerical aspects of a low-cost approach towards developing plasma-based oxygen sensor from household candle flame. In this perspective, we give an opinion about a diverse range of scientific insight together, identify the short comings, and open the path for new physical–chemistry device developments of oxygen sensor along with providing a guideline for innovators in oxygen sensing.

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“…Oxygen can also be detected using several bulk instruments, such as AFM and x-rays to obtain fast results in a limited time. Researchers have used graphane, self-chargeable nano-bio-supercapacitors with microelectronic circuits to sense oxygen and blood plasma 33,34 . However, these techniques are limited to rapid PoC applications.…”

Section: Selection Of Nanomaterialsmentioning

confidence: 99%

Towards real-time oxygen sensing: From nanomaterials to plasma

Vinitha¹,

Chinmaya²,

CV³

et al. 2021

Preprint

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A significantly large scope is available for the scientific and engineering developments of high-throughput ultra-high sensitive oxygen sensors. We give a perspective of oxygen sensing for two physical states of matters -solid-state nanomaterials and plasma. From single-molecule experiments to material selection, we reviewed various aspects of sensing, such as capacitance, photophysics, electron mobility, response time, and a yearly progress. Towards miniaturisation, we have highlighted the benefit of lab-on-chip-based devices and showed exemplary measurements of fast real-time oxygen sensing. From the physicalchemistry perspective, plasma holds a strong potential in the application of oxygen sensing. We investigated the current state-of-the-art of electron density, temperature, and design issues of plasma systems. We also show a numerical aspects of low-cost approach towards developing plasma-based oxygen sensor from household candle flame. In this perspective, we give an opinion about a diverse range of scientific insight together, identifies the short comings, and opens the path for new physical-chemistry device developments of oxygen sensor along with providing a guideline for innovators in oxygen sensing.

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Graphene-based sensing of oxygen transport through pulmonary membranes

Cited by 18 publications

References 68 publications

Polymer–Lipid Hybrid Materials

Polymer–Lipid Hybrid Materials

Towards Real-Time Oxygen Sensing: From Nanomaterials to Plasma

Towards real-time oxygen sensing: From nanomaterials to plasma

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