Graphene‐Based Nanomaterials for Neuroengineering: Recent Advances and Future Prospective

Kumar, Raj; Rauti, Rossana; Scaini, Denis; Antman‐Passig, Merav; Meshulam, Ohad; Naveh, Doron; Ballerini, Laura; Shefi, Orit

doi:10.1002/adfm.202104887

Cited by 23 publications

(15 citation statements)

References 130 publications

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“…In the last two decades, tremendous progress has been made. However, the use of most of the new nanomaterials is limited due to toxicity and low biodegradability [6]. Recently, the interest in the field of biodegradable components has increased because of the possibility of tailoring their properties and biodegradation characteristics [7].…”

Section: Introductionmentioning

confidence: 99%

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

et al. 2021

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Bone-related diseases have been increasing worldwide, and several nanocomposites have been used to treat them. Among several nanocomposites, polyhydroxybutyrate (PHB)-based nanocomposites are widely used in drug delivery and tissue engineering due to their excellent biocompatibility and biodegradability. However, PHB use in bone tissue engineering is limited due to its inadequate physicochemical and mechanical properties. In the present work, we synthesized PHB-based nanocomposites using a nanoblend and nano-clay with modified montmorillonite (MMT) as a filler. MMT was modified using trimethyl stearyl ammonium (TMSA). Nanoblend and nano-clay were fabricated using the solvent-casting technique. Inspection of the composite structure revealed that the basal spacing of the polymeric matrix material was significantly altered depending on the loading percentage of organically modified montmorillonite (OMMT) nano-clay. The PHB/OMMT nanocomposite displayed enhanced thermal stability and upper working temperature upon heating as compared to the pristine polymer. The dispersed (OMMT) nano-clay assisted in the formation of pores on the surface of the polymer. The pore size was proportional to the weight percentage of OMMT. Further morphological analysis of these blends was carried out through FESEM. The obtained nanocomposites exhibited augmented properties over neat PHB and could have an abundance of applications in the industry and medicinal sectors. In particular, improved porosity, non-immunogenic nature, and strong biocompatibility suggest their effective application in bone tissue engineering. Thus, PHB/OMMT nanocomposites are a promising candidate for 3D organ printing, lab-on-a-chip scaffold engineering, and bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

et al. 2021

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“…The interaction of GBMs with neurons and astrocytes is still poorly investigated and unclear, due to the variable methods for GBM production that influence the oxygen content, lateral size, contaminants, and number of layers [ 155 ]. In one of the earlier studies, Defterali et al using rGO showed good neuronal and glial biocompatibility [ 156 , 157 ]. It seems plausible that carbon nanomaterial might modulate neuroinflammation, a common feature of neurodegenerative diseases [ 158 ].…”

Section: Approaches For Mirna Therapeutic Deliverymentioning

confidence: 99%

Opportunities Offered by Graphene Nanoparticles for MicroRNAs Delivery for Amyotrophic Lateral Sclerosis Treatment

et al. 2021

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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration and death of motor neurons. This neurodegenerative disease leads to muscle atrophy, paralysis, and death due to respiratory failure. MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) with a length of 19 to 25 nucleotides, participating in the regulation of gene expression. Different studies have demonstrated that miRNAs deregulation is critical for the onset of a considerable number of neurodegenerative diseases, including ALS. Some studies have underlined how miRNAs are deregulated in ALS patients and for this reason, design therapies are used to correct the aberrant expression of miRNAs. With this rationale, delivery systems can be designed to target specific miRNAs. Specifically, these systems can be derived from viral vectors (viral systems) or synthetic or natural materials, including exosomes, lipids, and polymers. Between many materials used for non-viral vectors production, the two-dimensional graphene and its derivatives represent a good alternative for efficiently delivering nucleic acids. The large surface-to-volume ratio and ability to penetrate cell membranes are among the advantages of graphene. This review focuses on the specific pathogenesis of miRNAs in ALS and on graphene delivery systems designed for gene delivery to create a primer for future studies in the field.

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“…With the growing use of graphene materials, there are parallel public concerns about the safety of their release into the environment [ 10 ]. In contrast to the long-term and in-depth research that has been conducted into GFN exposure in animals [ 2 , 11 , 12 , 13 , 14 , 15 ], studies into the effects of GFNs on plants are just beginning.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Graphene-Family Nanomaterials on Plant Growth: A Review

et al. 2022

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Numerous reports of graphene-family nanomaterials (GFNs) promoting plant growth have opened up a wide range of promising potential applications in agroforestry. However, several toxicity studies have raised growing concerns about the biosafety of GFNs. Although these studies have provided clues about the role of GFNs from different perspectives (such as plant physiology, biochemistry, cytology, and molecular biology), the mechanisms by which GFNs affect plant growth remain poorly understood. In particular, a systematic collection of data regarding differentially expressed genes in response to GFN treatment has not been conducted. We summarize here the fate and biological effects of GFNs in plants. We propose that soil environments may be conducive to the positive effects of GFNs but may be detrimental to the absorption of GFNs. Alterations in plant physiology, biochemistry, cytological structure, and gene expression in response to GFN treatment are discussed. Coincidentally, many changes from the morphological to biochemical scales, which are caused by GFNs treatment, such as affecting root growth, disrupting cell membrane structure, and altering antioxidant systems and hormone concentrations, can all be mapped to gene expression level. This review provides a comprehensive understanding of the effects of GFNs on plant growth to promote their safe and efficient use.

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Graphene‐Based Nanomaterials for Neuroengineering: Recent Advances and Future Prospective

Cited by 23 publications

References 130 publications

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

Opportunities Offered by Graphene Nanoparticles for MicroRNAs Delivery for Amyotrophic Lateral Sclerosis Treatment

The Effects of Graphene-Family Nanomaterials on Plant Growth: A Review

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