Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering

Zhao, Hong; Ding, Ruihua; Zhao, Xin; Li, Yiwei; Qu, Liangliang; Pei, Hao; Yildirimer, Lara; Wu, Zhengwei; Zhang, Weixia

doi:10.1016/j.drudis.2017.04.002

Cited by 267 publications

(150 citation statements)

References 200 publications

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“…Accordingly, it can act as a useful building block for versatile functional materials synthesis, furthermore, one of the main advantages of GO over its nonoxidized counterpart is its ability to form stable solutions in water and most organic solvents. These features allow the GO and the various GO‐based composites to play a significant role in medical and biological applications (Bitounis, Ali‐Boucetta, Hong, Min, & Kostarelos, ; Sanchez, Jachak, Hurt, & Kane, ), such as tissue engineering (Goenka, Sant, & Sant, ; Ku, Lee, & Park, ; Zhao et al, ), drug delivery carriers (Bao et al, ; Goenka et al, ), cellular imaging (Zhao et al, ), biosensor (Liu, Yu, Zeng, Miao, & Dai, ), and antibacterial material (Akhavan & Ghaderi, ; Hu et al, ). In particular, the potential of these nanomaterials has attracted significant attention for bone tissue engineering and regenerative medicine (Bouzid, Sinitskii, & Lim, ).…”

Section: Introductionmentioning

confidence: 99%

In situ syntheses of hydroxyapatite‐grafted graphene oxide composites

Iacoboni

Perrozzi

Macera

et al. 2019

J Biomedical Materials Res

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In this study, we examined three different syntheses of hydroxyapatite (HAp) and graphene oxide–hydroxyapatite (GO–HAp) composites with a GO content of 9, 33, and 43% wt. The materials were prepared from various precursors of calcium and phosphate ions, using an in situ synthesis method, with mild conditions to avoid reducing the GO. In situ bonding technology proposed that calcium ions bond with GO at first and then HAp nanoflakes in situ grow on GO sheets, forming GO–HAp nanocomposite. The aim of the present work was to analyze the differences due to the use of different starting reagents and verify, with the addition of increasing amounts of GO, the changes in morphology, crystallinity, and solubility of the obtained HAp composites. Detailed structural and morphological characterization studies of the composites were carried out using scanning electron microscopy, energy dispersive X‐ray spectrometry, X‐ray powder diffraction, Raman spectroscopy, and Fourier transform infrared spectroscopy. We found that GO sheets act as a nucleation site for HAp mineralization, but we observed a loss of the crystallographic order due to the intercalation of the graphenic sheets between the HAp particles.

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Section: Introductionmentioning

confidence: 99%

In situ syntheses of hydroxyapatite‐grafted graphene oxide composites

Iacoboni

Perrozzi

Macera

et al. 2019

J Biomedical Materials Res

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“…PVA has been used in biomedical and pharmaceutical applications as mentioned previously. Graphene derivatives and graphene-inorganic hybrid materials are also used as biomedical materials due to their unique properties [71]. Biomedical applications of these nanomaterials include drug and gene delivery, biosensing and bioimaging systems, tissue engineering and other therapeutic applications.…”

Section: Inhibition Of Bacterial Growth By Pva/go-agnps Nanocompositesmentioning

confidence: 99%

Synthesis, Physical, Mechanical and Antibacterial Properties of Nanocomposites Based on Poly(vinyl alcohol)/Graphene Oxide–Silver Nanoparticles

et al. 2020

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The design of new materials with antimicrobial properties has emerged in response to the need for preventing and controlling the growth of pathogenic microorganisms without the use of antibiotics. In this study, partially reduced graphene oxide decorated with silver nanoparticles (GO–AgNPs) was incorporated as a reinforcing filler with antibacterial properties to poly(vinyl alcohol) (PVA) for preparation of poly(vinyl alcohol)/graphene oxide-silver nanoparticles nanocomposites (PVA/GO–AgNPs). AgNPs, spherical in shape and with an average size of 3.1 nm, were uniformly anchored on the partially reduced GO surface. PVA/GO–AgNPs nanocomposites showed exfoliated structures with improved thermal stability, tensile properties and water resistance compared to neat PVA. The glass transition and crystallization temperatures of the polymer matrix increased with the incorporation of the hybrid. The nanocomposites displayed antibacterial activity against Staphylococcus aureus and Escherichia coli in a filler content- and time-dependent manner. S. aureus showed higher susceptibility to PVA/GO–AgNPs films than E. coli. Inhibitory activity was higher when bacterial cells were in contact with nanocomposite films than when in contact with leachates coming out of the films. GO–AgNPs based PVA nanocomposites could find application as wound dressings for wound healing and infection prevention.

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“…Recently, quantum dots are used in many biotechnological appliances [6,62]. These fluorescent nanocrystals are utilized in many immunofluorescence assays [63], tissue engineering [64], DNA array technology [65], and other cell biology techniques [66] where fluorescence measurements are occupied. Single-molecule level studies of living cells [67] and targeted drug delivery for cancer treatment [68] are some other applications in medicine.…”

Section: Biomedical Applicationmentioning

confidence: 99%

Magnetic and Quantum Dot Nanoparticles for Drug Delivery and Diagnostic Systems

Munasinghe¹,

Aththapaththu²,

Jayarathne³

2020

Colloid Science in Pharmaceutical Nanotechnology

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Nanoparticles are being used tremendously in biomedical sciences due to their promising chemical and physical properties. Magnetic nanoparticles and quantum dot nanocrystals are two of the main nanoparticle types used in the biomedical industry. The surface of these nanoparticles is further modified in order to obtain biocompatibility and surface functionalization. Magnetic properties, fluorescence, nanometer size, and availability of sites to modify its surface for bioconjugation provide greater potential to use these nanoparticles in targeted drug delivery technique and diagnostics. As a result, these nanoparticles create massive developments in the industrial operations. In this chapter, an overview of the nanoparticles used in drug delivery and diagnostic systems will be discussed. In addition, advantages in encapsulation of magnetic and quantum dot nanoparticles for bioconjugation and different methods of drug delivery will be addressed.

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Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering

Cited by 267 publications

References 200 publications

In situ syntheses of hydroxyapatite‐grafted graphene oxide composites

In situ syntheses of hydroxyapatite‐grafted graphene oxide composites

Synthesis, Physical, Mechanical and Antibacterial Properties of Nanocomposites Based on Poly(vinyl alcohol)/Graphene Oxide–Silver Nanoparticles

Magnetic and Quantum Dot Nanoparticles for Drug Delivery and Diagnostic Systems

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