Graphene-based nanomaterials for cancer therapy and anti-infections

Wang, Yan; Li, Juan; Li, Xiaobin; Shi, Jinping; Jiang, Zhaotan; Zhang, Can Yang

doi:10.1016/j.bioactmat.2022.01.045

Cited by 41 publications

(30 citation statements)

References 148 publications

(171 reference statements)

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“…For example, smaller GO flakes showed, in general, less toxicity. The size of GO is also important to be always taken into account, as a mechanism by which the material internalises into a target cell [244][245][246].…”

Section: Discussionmentioning

confidence: 99%

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Krasteva

Georgieva

2022

Pharmaceutics

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Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases per annum, whereas the lack of effective therapies highlights the need for novel therapeutic approaches. Conventional treatment methods, such as surgery, chemotherapy and radiotherapy, are widely applied in oncology practice. Their therapeutic success is little, and therefore, the search for novel technologies is ongoing. Many efforts have focused recently on the development of safe and efficient cancer nanomedicines. Nanoparticles are among them. They are uniquewith their properties on a nanoscale and hold the potential to exploit intrinsic metabolic differences between cancer and healthy cells. This feature allows them to induce high levels of toxicity in cancer cells with little damage to the surrounding healthy tissues. Graphene oxide is a promising 2D material found to play an important role in cancer treatments through several strategies: direct killing and chemosensitization, drug and gene delivery, and phototherapy. Several new treatment approaches based on nanoparticles, particularly graphene oxide, are currently under research in clinical trials, and some have already been approved. Here, we provide an update on the recent advances in nanomaterials-based CRC-targeted therapy, with special attention to graphene oxide nanomaterials. We summarise the epidemiology, carcinogenesis, stages of the CRCs, and current nanomaterials-based therapeutic approaches for its treatment.

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Section: Discussionmentioning

confidence: 99%

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Krasteva

Georgieva

2022

Pharmaceutics

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“…The decline in number of publications in 2020 may be linked to the impact of COVID-19 globally. [21][22][23] The trend is due to the pronounced ability of helicobacter bio lm to raise the rate of antibiotic resistance to helicobacter. 24 In our study, bibliographic coupling was found for publications arising from 253 institutions over 42 countries worldwide in the eld that have appeared since 1998.…”

Section: Discussionmentioning

confidence: 99%

“…15 Since then, researchers have reported bio lms in almost all natural and industrial ecosystems, especially in infectious diseases. [16][17][18][19][20] In this study, we used a combination of bibliometric and visualized analyses to grasp the current state of the eld on helicobacter bio lms research. These articles re ected major advances and annual publications' trend about helicobacter bio lm during the last two decades.…”

Section: Discussionmentioning

confidence: 99%

Global trends of Helicobacter pylori biofilm research in the past two decades: A bibliometric study

Wang

Xie

2022

Preprint

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Background: Helicobacter pylori biofilm formation is a key factor of refractory helicobacter pylori infection. This study aimed to access the research trends of helicobacter pylori biofilm.Methods: Publications from 1998 to 2022 were retrieved from the Web of Science Core Collection database. Different kinds of software, EXCEL, VOSviewer, and the online bibliometric analysis platform were used to evaluate and visualize the bibliometric data.Results: A total of 154 publications were finally identified, and the annual number of publications showed a rising trend. The China made the greatest contributions to this research field, while the journal of Helicobacter was the most productive journal. Grande rossella published the most papers, and the most productive institution was G dannunzio University. Co-occurrence network maps revealed that the keyword of “Helicobacter pylori” ranked first in research field, and the keyword of “biofilm formation” and “in vitro” began to appear in the past 3 to 5 years.Conclusion: The annual number of publications on helicobacter pylori biofilm have grown steadily in the past two decades and will continue to grow. Future research hot spots will domain in the establishment of helicobacter pylori biofilm in vitro model and mechanism of helicobacter pylori biofilm formation.

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“…PTAs include inorganic materials and organic materials. Inorganic materials include noble metals (e.g., gold nanoparticles and platinum nanoparticles) [ 43 , 44 ], carbon-based nanomaterials (e.g., carbon nanotubes, graphene, graphene oxide, carbon quantum dots, and mesoporous carbon) [ 40 , 45 , 46 , 47 ]. Organic materials include NIR-responsive small molecules and semiconducting polymer nanoparticles [ 48 , 49 , 50 ] (e.g., cyanine, porphyrin, copper phthalocyanine, and diketone pyrrole pyrrole).…”

Section: Photothermal Transduction Agentsmentioning

confidence: 99%

Antitumor Applications of Photothermal Agents and Photothermal Synergistic Therapies

Cheng

et al. 2022

IJMS

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As a new tumor treatment strategy, photothermal therapy (PTT) has the advantages of accuracy, ease of administration, a high efficiency and low side effects. Photothermal transduction agents (PTAs) are the key factor which play an important role in PTT. The mechanism of PTT is discussed in detail. The photothermal conversion efficiency (PCE) can be improved by increasing the light absorption and reducing the light scattering of photothermal conversion agents. Additionally, non-radiative relaxation path attenuation can also promote energy conversion to obtain a higher value in terms of PCE. The structure and photothermal characteristics of various kinds of PTAs (metal materials, carbon-based nanomaterials, two-dimensional nanomaterials, and organic materials) were compared and analyzed. This paper reviews the antitumor applications of photothermal synergistic therapies, including PTT combined with immunotherapy, chemotherapy, and photodynamic therapy. This review proposes that these PTAs promote the development of photothermal synergistic therapies and have a great potential in the application of tumor treatment.

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Graphene-based nanomaterials for cancer therapy and anti-infections

Cited by 41 publications

References 148 publications

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Global trends of Helicobacter pylori biofilm research in the past two decades: A bibliometric study

Antitumor Applications of Photothermal Agents and Photothermal Synergistic Therapies

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