Graphene-Based Nanomaterials as Drug Delivery Carriers

Jeong, Woo Yeup; Choi, Hye Eun; Kim, Ki Su

doi:10.1007/978-981-16-4923-3_6

Cited by 12 publications

(4 citation statements)

References 59 publications

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“…Good biosafety and stability are the prerequisites for the further development and application of nanoparticles [43][44][45]. Cytotoxicity, blood biochemistry and HE results showed that the nanoparticles did not exhibit significant cellular damage, liver and kidney toxicity, and pathological damage to major metabolic organs, and the one-week monitoring of the T 2 relaxation rate showed that the relaxation rate was only slightly reduced, suggesting that the nanoparticles have good short-term stability.…”

Section: Discussionmentioning

confidence: 99%

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Yin,

Gao,

Zhang

et al. 2024

Biomed. Mater.

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This study developed a probe Fe3O4-Cy5.5-trastuzumab with fluorescence and magnetic resonance imaging functions that can target breast cancer with high HER2 expression, aiming to provide a new theoretical method for the diagnosis of early breast cancer.Methods:Fe3O4-Cy5.5-trastuzumab nanoparticles were combined with Fe3O4 for T2 imaging and Cy5.5 for near-infrared imaging, and coupled with trastuzumab for HER2 targeting. We characterized the nanoparticles used transmission electron microscopy, hydration particle size, Zeta potential, UV and fourier transform infrared spectroscopy, and examined its magnetism, fluorescence, and relaxation rate related properties. CCK-8 and blood biochemistry analysis evaluated the biosafety and stability of the nanoparticles, and validated the targeting ability of Fe3O4-Cy5.5 trastuzumab nanoparticles through in vitro and in vivo cell and animal experiments.Results: Characterization results showed the successful synthesis of Fe3O4-Cy5.5-trastuzumab nanoparticles with a diameter of 93.72±6.34 nm. The nanoparticles showed a T2 relaxation rate 42.29 mM-1s-1, magnetic saturation strength of 27.58 emg/g. Laser confocal and flow cytometry uptake assay showed that the nanoparticles could effectively target HER2 expressed by breast cancer cells. As indicated by in vitro and in vivo studies, Fe3O4-Cy5.5-trastuzumab were specifically taken up and effectively aggregated to tumor regions with prominent NIRF/MR imaging properties. CCK-8, blood biochemical analysis and histological results suggested Fe3O4-Cy5.5-trastuzumab that exhibited low toxicity to major organs and good in vivo biocompatibility. The prepared Fe3O4-Cy5.5-trastuzumab exhibited excellent targeting, NIRF/MR imaging performance. It is expected to serve as a safe and effective diagnostic method that lays a theoretical basis for the effective diagnosis of of early breast cancer.Conclusion: This study successfully prepared a kind of nanoparticles with near-infrared fluorescence imaging and T2 imaging properties, which is expected to serve as a new theory and strategy for early detection of breast cancer.KeywordsBreast cancer ; HER2 ;Trastuzumab ;T2 imaging properties; Near infrared fluorescence imaging;Early detection 

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Section: Discussionmentioning

confidence: 99%

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Yin,

Gao,

Zhang

et al. 2024

Biomed. Mater.

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“…Graphene-based materials are attractive for biomedical applications due to their physicochemical and biological properties, such as large surface area, chemical and mechanical stability, high thermal conductivity, and biocompatibility. Graphene and its derivatives can be conjugated with other aromatic materials on the surface through π–π stacking or electrostatic interactions, and the large surface area of graphene increases the opportunities for multi-drug delivery [ 28 ]. In one of the first works in the field of graphene-based targeting of the TRAIL pathway, a sequentially functionalized graphene-based nanostructure was developed as a new cellular protease-mediated programmed co-delivery system, integrating TRAIL protein and the intracellular-functioning small molecule doxorubicin (DOX).…”

Section: Inorganic Nanoparticles Modified With Trail Pathway-targetin...mentioning

confidence: 99%

Recent Advances in the Development of Nanodelivery Systems Targeting the TRAIL Death Receptor Pathway

2023

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The TRAIL (TNF-related apoptosis-inducing ligand) apoptotic pathway is extensively exploited in the development of targeted antitumor therapy due to TRAIL specificity towards its cognate receptors, namely death receptors DR4 and DR5. Although therapies targeting the TRAIL pathway have encountered many obstacles in attempts at clinical implementation for cancer treatment, the unique features of the TRAIL signaling pathway continue to attract the attention of researchers. Special attention is paid to the design of novel nanoscaled delivery systems, primarily aimed at increasing the valency of the ligand for improved death receptor clustering that enhances apoptotic signaling. Optionally, complex nanoformulations can allow the encapsulation of several therapeutic molecules for a combined synergistic effect, for example, chemotherapeutic agents or photosensitizers. Scaffolds for the developed nanodelivery systems are fabricated by a wide range of conventional clinically approved materials and innovative ones, including metals, carbon, lipids, polymers, nanogels, protein nanocages, virus-based nanoparticles, dendrimers, DNA origami nanostructures, and their complex combinations. Most nanotherapeutics targeting the TRAIL pathway are aimed at tumor therapy and theranostics. However, given the wide spectrum of action of TRAIL due to its natural role in immune system homeostasis, other therapeutic areas are also involved, such as liver fibrosis, rheumatoid arthritis, Alzheimer’s disease, and inflammatory diseases caused by bacterial infections. This review summarizes the recent innovative developments in the design of nanodelivery systems modified with TRAIL pathway-targeting ligands.

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“…Conversely, MWCNTs can serve as scaffolds for peripheral nerve repair as well as nerve conduit-targeted drug carriers [96]. In contrast, graphene not only efficiently conducts heat and electricity, but also has a high degree of low cytotoxicity and biocompatibility [137].…”

Section: A Comparative Study Of Biomimetic Hydrogels and Biomaterials...mentioning

confidence: 99%

Biomimetic Hydrogel Applications and Challenges in Bone, Cartilage, and Nerve Repair

Gao,

Zhang,

Zhou

2023

Pharmaceutics

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Tissue engineering and regenerative medicine is a highly sought-after field for researchers aiming to compensate and repair defective tissues. However, the design and development of suitable scaffold materials with bioactivity for application in tissue repair and regeneration has been a great challenge. In recent years, biomimetic hydrogels have shown great possibilities for use in tissue engineering, where they can tune mechanical properties and biological properties through functional chemical modifications. Also, biomimetic hydrogels provide three-dimensional (3D) network spatial structures that can imitate normal tissue microenvironments and integrate cells, scaffolds, and bioactive substances for tissue repair and regeneration. Despite the growing interest in various hydrogels for biomedical use in previous decades, there are still many aspects of biomimetic hydrogels that need to be understood for biomedical and clinical trial applications. This review systematically describes the preparation of biomimetic hydrogels and their characteristics, and it details the use of biomimetic hydrogels in bone, cartilage, and nerve tissue repair. In addition, this review outlines the application of biomimetic hydrogels in bone, cartilage, and neural tissues regarding drug delivery. In particular, the advantages and shortcomings of biomimetic hydrogels in biomaterial tissue engineering are highlighted, and future research directions are proposed.

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Graphene-Based Nanomaterials as Drug Delivery Carriers

Cited by 12 publications

References 59 publications

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Recent Advances in the Development of Nanodelivery Systems Targeting the TRAIL Death Receptor Pathway

Biomimetic Hydrogel Applications and Challenges in Bone, Cartilage, and Nerve Repair

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Graphene-Based Nanomaterials as Drug Delivery Carriers

Cited by 12 publications

References 59 publications

Fe3O4-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Fe3O4-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Recent Advances in the Development of Nanodelivery Systems Targeting the TRAIL Death Receptor Pathway

Biomimetic Hydrogel Applications and Challenges in Bone, Cartilage, and Nerve Repair

Contact Info

Product

Resources

About

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer