Graphene-based nanomaterials and their potentials in advanced drug delivery and cancer therapy

Liu, Jinzhao; Dong, Jia; Zhang, Ting; Peng, Qiang

doi:10.1016/j.jconrel.2018.07.034

Cited by 201 publications

(95 citation statements)

References 159 publications

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“…For example, graphene has been used for drug transport, stem cell engineering, cell imaging, and tumor therapy (Zhu et al, 2010). Graphene oxide attracted much attention due to the larger surface and oxygen groups, It has been demonstrated that graphene oxide can be used in drug delivery of cancer therapy (Liu et al, 2018). In addition, study has reported that graphene oxide can be used in cell imaging without any additional fluorescent protein (Cheng et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Graphene Enhances Neural Stem Cell Proliferation Through Metabolic Regulation

Fang

Zhang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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Graphene consists of two-dimensional sp2-bonded carbon sheets, a single or a few layers thick, which has attracted considerable interest in recent years due to its good conductivity and biocompatibility. Three-dimensional graphene foam (3DG) has been demonstrated to be a robust scaffold for culturing neural stem cells (NSCs) in vitro that not only supports NSCs growth, but also maintains cells in a more active proliferative state than 2D graphene films and ordinary glass. In addition, 3DG can enhance NSCs differentiation into astrocytes and especially neurons. However, the underlying mechanisms behind 3DG's effects are still poorly understood. Metabolism is the fundamental characteristic of life and provides substances for building and powering the cell. Metabolic activity is tightly tied with the proliferation, differentiation, and self-renewal of stem cells. This study focused on the metabolic reconfiguration of stem cells induced by culturing on 3DG. This study established the correlation between metabolic reconfiguration metabolomics with NSCs cell proliferation rate on different scaffold. Several metabolic processes have been uncovered in association with the proliferation change of NSCs. Especially, culturing on 3DG triggered pathways that increased amino acid incorporation and enhanced glucose metabolism. These data suggested a potential association between graphene and pathways involved in Parkinson's disease. Our work provides a very useful starting point for further studies of NSC fate determination on 3DG.

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Section: Discussionmentioning

confidence: 99%

Three-Dimensional Graphene Enhances Neural Stem Cell Proliferation Through Metabolic Regulation

Fang

Zhang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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“…Reduced GO (RGO) not only is decorated with multiple oxygen-containing functional groups but also restores the good electronic, thermal, and mechanical properties of graphene. Therefore, abundant organic synthesis principles can be employed with functional supramolecular nanoassemblies of π-conjugated molecules to realize a responsiveness to various stimuli, confirming graphene materials to be excellent scaffolds for various sensors [25][26][27][28][29][30].…”

Section: The Unique Roles and Advantages Of Graphene Materials For Tamentioning

confidence: 98%

Graphene Nanostructure-Based Tactile Sensors for Electronic Skin Applications

et al. 2019

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HIGHLIGHTS• Tremendous progress has been advanced by research into graphene and its derivatives with great benefits toward low-cost, portable, and real-time tactile sensors/electronic skin.• The review presented herein direct future efforts aimed at high-quality graphene-based tactile sensors and their implications for the wider scientific community.• The paper also are informative regarding some basic and crucial issues regarding graphene and its derivatives, such as charge-transport principles, doping/trapping behaviors, correlations between structure/morphology and properties/functions.ABSTRACT Skin is the largest organ of the human body and can perceive and respond to complex environmental stimulations. Recently, the development of electronic skin (E-skin) for the mimicry of the human sensory system has drawn great attention due to its potential applications in wearable human health monitoring and care systems, advanced robotics, artificial intelligence, and human-of graphene materials; (2) state-of-the-art protocols recently developed for high-performance tactile sensing, including representative examples; and (3) perspectives and current challenges for graphene-based tactile sensors in E-skin applications. A summary of these cutting-edge developments intends to provide readers with a deep understanding of the future design of high-quality tactile sensing devices and paves a path for their future commercial applications in the field of E-skin.

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“…47 In the last decade, many efforts have been directed toward the development of nanomaterials, and GO has been extensively used in drug delivery. 51,52 The large surface area of GO is an incomparable advantage for drug or gene delivery. 24,53 Moreover, there were no specific anti-OSCC nucleic acids that utilized GO as a gene delivery nanocarrier utilized in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

<p>Efficient miRNA Inhibitor Delivery with Graphene Oxide-Polyethylenimine to Inhibit Oral Squamous Cell Carcinoma</p>

Ou¹,

Sun²,

Liu³

et al. 2020

IJN

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Background: MicroRNAs (miRNAs) are widely believed to be promising targets for oral squamous cell carcinoma (OSCC) gene therapy. miR-214 has been identified as a promoter of OSCC aggression and metastasis. Methods: Graphene oxide-polyethylenimine (GO-PEI) complexes were prepared and loaded with a miRNA inhibitor at different N/P ratios. The transfection efficiency of GO-PEI-inhibitor was tested in Cal27 and SCC9 cells. Moreover, the tumor inhibition ability of GO-PEI-inhibitor was measured in an OSCC xenograft mouse model by intratumoral injection. Results: Here, we show that a GO-PEI complex efficiently delivers a miR-214 inhibitor into OSCC cells and controls the intracellular release of the miR-214 inhibitor. These results indicate that the GO-PEI-miR-214 inhibitor complex efficiently inhibited cellular miR-214, resulting in a decrease in OSCC cell invasion and migration and an increase in cell apoptosis by targeting PTEN and p53. In the xenograft mouse model, the GO-PEI-miR-214 inhibitor complex significantly prevented tumor volume growth. Conclusion: This study indicates that functionalized GO-PEI with low toxicity has promising potential for miRNA delivery for the treatment of OSCC.

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Graphene-based nanomaterials and their potentials in advanced drug delivery and cancer therapy

Cited by 201 publications

References 159 publications

Three-Dimensional Graphene Enhances Neural Stem Cell Proliferation Through Metabolic Regulation

Three-Dimensional Graphene Enhances Neural Stem Cell Proliferation Through Metabolic Regulation

Graphene Nanostructure-Based Tactile Sensors for Electronic Skin Applications

<p>Efficient miRNA Inhibitor Delivery with Graphene Oxide-Polyethylenimine to Inhibit Oral Squamous Cell Carcinoma</p>

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