Graphene-Based Nanomaterials and Their Interactions with Lipid Membranes

Mandal, Priya; Ghosh, Sajal K.

doi:10.1021/acs.langmuir.3c02805

Cited by 1 publication

(1 citation statement)

References 101 publications

(218 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Graphene nanosheets have become promising candidates in biotechnology and biomedicine fields, such as drug delivery, , bioimaging, and antimicrobial and photothermal therapy of tumor or infection. , At the same time, biosafety of carbon nanomaterials is also an issue that cannot be ignored . Potential toxicity may come from the disturbance to the cell membrane and their hybrid structure, as well as other compositions that closely related to cellular functions . Understanding the intricate interactions of graphene nanosheets on cell membranes is fundamental to determining their potential biomedical use as well as biocompatibility and cytotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Cholesterols Induced Distinctive Entry of the Graphene Nanosheet into the Cell Membrane

Tan,

Hu,

2024

ACS Omega

View full text Add to dashboard Cite

Graphene nanosheets are highly valued in the biomedical field due to their potential applications in drug delivery, biological imaging, and biosensors. Their biological effects on mammalian cells may be influenced by cholesterols, which are crucial components in cell membranes that take part in many vital processes. Therefore, it is particularly important to investigate the effect of cholesterols on the transport mechanism of graphene nanosheets in the cell membrane as well as the final stable configuration of graphene, which may have an impact on cytotoxicity. In this paper, the molecular details of a graphene nanosheet interacting with a 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine (DPPC) membrane with cholesterols were studied using molecular dynamics simulations. Results showed that the structure of the graphene nanosheet transits from the cut-in state in a pure DPPC membrane to being sandwiched between two DPPC leaflets when cholesterols reach a certain concentration. The underlying mechanism showed that cholesterols are preferentially adsorbed on the graphene nanosheet, which causes a larger disturbance to the nearby DPPC tails and thus guides the graphene nanosheet into the core of lipid bilayers to form a sandwiched structure. Our results are helpful for understanding the fundamental interaction mechanism between the graphene nanosheet and cell membrane and to explore the potential applications of the graphene nanosheet in biomedical sciences.

show abstract