Graphene-based multifunctional nanosystems for simultaneous detection and treatment of breast cancer

Dolatkhah, Mitra; Hashemzadeh, Nastaran; Barar, Jaleh; Adibkia, Khosro; Aghanejad, Ayuob; Barzegar-Jalali, Mohammad; Omidi, Yadollah

doi:10.1016/j.colsurfb.2020.111104

Cited by 43 publications

(9 citation statements)

References 154 publications

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“…The absorbance of the samples was measured with a UV-Vis spectrophotometer at wavelengths of 310 and 480 nm. The standard curve was prepared to investigate the relationship between the released CP and MET (Shen et al., 2012 ; Alemi et al., 2020 ; Dolatkhah et al., 2020 ).…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

Zhang

Han

et al. 2021

Drug Delivery

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Hepatocellular carcinoma (HCC) is widespread cancer with a high degree of morbidity and mortality in individuals worldwide and a serious concern for its resistance to present chemotherapy drugs. In this investigation, the combination of cisplatin (CPT) and metformin (MET) to kill the HepG2 and caco-2 cells was developed into a new pH-responding magnetic nanocomposite based on reduced graphene oxide. Polyhydroxyethyl methacrylic (PHEA) was then linked employing grafting from approach to the reduced graphene oxide by ATRP polymerization (Fe 3 O 4 @rGO-G-PSEA). FT-IR, SEM, XRD, DLS, and TGA analyses evaluated physicochemical characteristics of the nanocomposite. In addition, the cellular uptake property of the nanocomposites was examined by the HepG2 cells. The outcomes of cell viability results indicate that the nanoparticles loaded with MET&CPT showed the lowest concentration rate of HepG2 and Caco-2 cells compared to the drug-loaded single nanocomposite groups and free drugs. The histological analysis has demonstrated relatively safe and does not produce different stress such as swelling and inflammation of the mice organs. Our results show the enhancement in cytotoxicity in HepG2 and Cocoa-2 cells by MET and CPT graphene oxide-based nanocomposite by promoting apoptotic response. Moreover, Fe 3 O 4 @rGO-G-PSEA showed potent in vivo antitumor efficacy but showed no adverse toxicity to normal tissues. Together, this study can provide insight into how surface embellishment may tune these nanocomposites' tumor specificity and provide the basis for developing anticancer efficacy.

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Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

Zhang

Han

et al. 2021

Drug Delivery

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“…PDT only produces ROS in the tumor after local irradiation with excitation light, making it less invasive and confined. Furthermore, PDT has shown promising results in the diagnosis and treatment of cancers, such as breast, colorectal, and skin cancers, because of the mechanism of action of PSs, which does not cause drug tolerance (8)(9)(10). PDT can also induce immunogenic cell death (ICD), promote the release of tumor-associated antigens (TAAs) from tumor cell remnants, and increase the proliferation, activation, and infiltration of antigen-presenting cells and antigen-specific T cells (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Hua

Gan

et al. 2021

Front. Oncol.

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Photodynamic therapy (PDT) is a low invasive antitumor therapy with fewer side effects. On the other hand, immunotherapy also has significant clinical applications in the treatment of cancer. Both therapies, on their own, have some limitations and are incapable of meeting the demands of the current cancer treatment. The efficacy of PDT and immunotherapy against tumor metastasis and tumor recurrence may be improved by combination strategies. In this review, we discussed the possibility that PDT could be used to activate immune responses by inducing immunogenic cell death or generating cancer vaccines. Furthermore, we explored the latest advances in PDT antitumor therapy in combination with some immunotherapy such as immune adjuvants, inhibitors of immune suppression, and immune checkpoint blockade.

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“…The use of GQDs to improve disease diagnosis and treatment has been demonstrated by several research groups [417][418][419][420][421]. Composites based on GQDs have also been studied by many researchers to further enhance their efficiency in biomedical applications.…”

Section: Cancer Cell and Tumor Therapymentioning

confidence: 99%

Graphene quantum dots: preparations, properties, functionalizations and applications

Tian,

Tang,

Teng

et al. 2024

Mater. Futures

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Due to its zero-dimensional property, graphene quantum dots (GQDs) has quantum confinement effect on the internal charge, so they show many properties different from the parent two-dimensional graphene, such as strong fluorescence, non-zero band gap and easily soluble in solvents. As a member of the family of carbon materials, GQDs also has biocompatibility and low toxicity, which is one of the reasons why GQDs can be widely used in the biomedical field .The edge effect of GQDs is also particularly important. By modifying the edge of GQDs, the performance of GQDs can be regulated. A lot of preparation technology of GQDs, probably can be divided into three categories, and top-down, bottom-up and chemical method, chemical method is different from other literature classification, mainly considering the certain of the preparation of GQDs way, not directly to block materials or direct synthesis of small molecule materials for GQDs, but through intermediate in chemical means under the action of changes and form GQDs. The detailed introduction of the optical, electrical, thermal and magnetic properties of GQDs is the premise of the performance regulation of GQDs. In addition to inheriting the excellent properties of graphene, GQDs also expand the properties of the parent material. The functionalization of GQDs mainly includes the doping technology of introducing heteroatom and the composite technology of combining with other substances to improve the performance of other substances. The performance of these functionalized products is also discussed. The original and functionalized properties of GQDs are based on the application of GQDs. In recent years, GQDs has been used in many fields, including optics, electricity, optoelectronics, biomedicine, energy, agriculture and some emerging interdisciplinary fields. Through the introduction and discussion of the recent research achievements of GQDs, this review mainly highlights the huge potential value of GQDs and puts forward the direction of the development of GQDs in the future.

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Graphene-based multifunctional nanosystems for simultaneous detection and treatment of breast cancer

Cited by 43 publications

References 154 publications

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Graphene quantum dots: preparations, properties, functionalizations and applications

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