Graphene active sensor arrays for long-term and wireless mapping of wide frequency band epicortical brain activity

Garcia‐Cortadella, Ramon; Schwesig, Gerrit; Jeschke, Christoph; Illa, Xavi; Gray, Anna L.; Savage, S.; Stamatidou, E.; Schießl, Ingo; Masvidal‐Codina, Eduard; Kostarelos, Kostas; Guimerà‐Brunet, Anton; Sirota, Anton; Garrido, José Antonio

doi:10.1038/s41467-020-20546-w

Cited by 55 publications

(81 citation statements)

References 84 publications

(66 reference statements)

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“…These values are many times higher with respect to silicon nanowire FETs, [41] organic FETs, [42,43] and other graphene-based FETs. [19,40,44,45] The higher the transconductance, the greater the sensing amplification of the FET when the sensing strategy is based on monitoring changes in I DS at a constant V G . It is also possible to observe a high homogeneity in terms of g m , since all the devices displayed a g m above 0.7 times the average value; a criterion previously considered as a good GFET reproducibility.…”

Section: Electrical Characterization and Functionalization Of The Gfetsmentioning

confidence: 99%

Biofunctionalization of Graphene‐Based FET Sensors through Heterobifunctional Nanoscaffolds: Technology Validation toward Rapid COVID‐19 Diagnostics and Monitoring

Piccinini

Fenoy

Cantillo

et al. 2022

Adv Materials Inter

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The biofunctionalization of graphene field‐effect transistors (GFETs) through vinylsulfonated‐polyethyleneimine nanoscaffold is presented for enhanced biosensing of severe acute respiratory‐related coronavirus 2 (SARS‐CoV‐2) spike protein and human ferritin, two targets of great importance for the rapid diagnostic and monitoring of individuals with COVID‐19. The heterobifunctional nanoscaffold enables covalent immobilization of binding proteins and antifouling polymers while the whole architecture is attached to graphene by multivalent π–π interactions. First, to optimize the sensing platform, concanavalin A is employed for glycoprotein detection. Then, monoclonal antibodies specific against SARS‐CoV‐2 spike protein and human ferritin are anchored, yielding biosensors with limit of detections of 0.74 and 0.23 nm, and apparent affinity constants () of 6.7 and 8.8 nm, respectively. Both biosensing platforms show good specificity, fast time response, and wide dynamic range (0.1–100 nm). Moreover, SARS‐CoV‐2 spike protein is also detected in spiked nasopharyngeal swab samples. To rigorously validate this biosensing technology, the GFET response is matched with surface plasmon resonance measurements, exhibiting linear correlations (from 2 to 100 ng cm−2) and good agreement in terms of KD values. Finally, the performance of the biosensors fabricated through the nanoscaffold strategy is compared with those obtained through the widely employed monopyrene approach, showing enhanced sensitivity.

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Section: Electrical Characterization and Functionalization Of The Gfetsmentioning

confidence: 99%

Biofunctionalization of Graphene‐Based FET Sensors through Heterobifunctional Nanoscaffolds: Technology Validation toward Rapid COVID‐19 Diagnostics and Monitoring

Piccinini

Fenoy

Cantillo

et al. 2022

Adv Materials Inter

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“…Due to the nanoscopic dimensions of graphenes, it is possible to assemble 0D, 1D and 2D materials. These are often dispersed in liquid environments working as molecular probes ( Sekhon et al, 2021 ) or assembled in monolayers for the fabrication of sensors ( Garcia-Cortadella et al, 2021 ). However, the production of scalable 3D GBMs is possible under particular conditions and using specific components ( Li et al, 2019 ; Bellucci and Tozzini, 2020 ).…”

Section: Graphene-based Materialsmentioning

confidence: 99%

Graphene Oxide and Biomolecules for the Production of Functional 3D Graphene-Based Materials

Passaretti

2022

Front. Mol. Biosci.

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Graphene and its derivatives have been widely employed in the manufacturing of novel composite nanomaterials which find applications across the fields of physics, chemistry, engineering and medicine. There are many techniques and strategies employed for the production, functionalization, and assembly of graphene with other organic and inorganic components. These are characterized by advantages and disadvantages related to the nature of the specific components involved. Among many, biomolecules and biopolymers have been extensively studied and employed during the last decade as building blocks, leading to the realization of graphene-based biomaterials owning unique properties and functionalities. In particular, biomolecules like nucleic acids, proteins and enzymes, as well as viruses, are of particular interest due to their natural ability to self-assemble via non-covalent interactions forming extremely complex and dynamic functional structures. The capability of proteins and nucleic acids to bind specific targets with very high selectivity or the ability of enzymes to catalyse specific reactions, make these biomolecules the perfect candidates to be combined with graphenes, and in particular graphene oxide, to create novel 3D nanostructured functional biomaterials. Furthermore, besides the ease of interaction between graphene oxide and biomolecules, the latter can be produced in bulk, favouring the scalability of the resulting nanostructured composite materials. Moreover, due to the presence of biological components, graphene oxide-based biomaterials are more environmentally friendly and can be manufactured more sustainably compared to other graphene-based materials assembled with synthetic and inorganic components. This review aims to provide an overview of the state of the art of 3D graphene-based materials assembled using graphene oxide and biomolecules, for the fabrication of novel functional and scalable materials and devices.

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“…Even densely organized polymer electrode arrays based on PEDOT:PSS with 1,024 channels were presented, proving the capability of measuring single unit activities of hundreds of neurons for a prolonged period (>5 months) in freely moving animals ( Figure 2 B) ( Chung et al., 2019 ). Moreover, there have been emerging approaches to fabricate organic materials-based transistors ( Garcia-Cortadella et al., 2020 , 2021 ; Rivnay et al., 2018 ; Spanu et al., 2021 ). In particular, the organic electrochemical transistor (OECT) has been investigated as a promising active transducer for its intrinsic amplification capability with tissue-compliant nature ( Khodagholy et al., 2013 ; Rivnay et al., 2018 ).…”

Section: Advances In Neural Device Platformsmentioning

confidence: 99%

Recent advances in recording and modulation technologies for next-generation neural interfaces

Hong¹,

Yoon²,

Jo³

et al. 2021

iScience

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Summary Along with the advancement in neural engineering techniques, unprecedented progress in the development of neural interfaces has been made over the past few decades. However, despite these achievements, there is still room for further improvements especially toward the possibility of monitoring and modulating neural activities with high resolution and specificity in our daily lives. In an effort of taking a step toward the next-generation neural interfaces, we want to highlight the recent progress in neural technologies. We will cover a wide scope of such developments ranging from novel platforms for highly specific recording and modulation to system integration for practical applications of novel interfaces.

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Graphene active sensor arrays for long-term and wireless mapping of wide frequency band epicortical brain activity

Cited by 55 publications

References 84 publications

Biofunctionalization of Graphene‐Based FET Sensors through Heterobifunctional Nanoscaffolds: Technology Validation toward Rapid COVID‐19 Diagnostics and Monitoring

Biofunctionalization of Graphene‐Based FET Sensors through Heterobifunctional Nanoscaffolds: Technology Validation toward Rapid COVID‐19 Diagnostics and Monitoring

Graphene Oxide and Biomolecules for the Production of Functional 3D Graphene-Based Materials

Recent advances in recording and modulation technologies for next-generation neural interfaces

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