Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemotherapy Combination Treatment of Cancer

Jin, Jun‐O; Guo, Mengyu; Liu, Jiaming; Zhou, Huige; Li, Jiayang; Wang, Liming; Liu, Huibiao; Li, Yuliang; Zhao, Yuliang; Chen, Chunying

doi:10.1021/acsami.7b17219

Cited by 130 publications

(77 citation statements)

References 35 publications

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“…Due to the negative potential of GDY surface, it would be beneficial to calcium deposition 63 . In addition, GDY nanosheets possess a high surface area, suggesting that they have a better drug loading capacity 64 . These indicated that the specific structure of GDY significantly improved the osteoinductive ability of TiO 2 nanofibers.…”

Section: Discussionmentioning

confidence: 99%

Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

et al. 2020

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Titanium implants have been widely used in bone tissue engineering for decades. However, orthopedic implant-associated infections increase the risk of implant failure and even lead to amputation in severe cases. Although TiO2 has photocatalytic activity to produce reactive oxygen species (ROS), the recombination of generated electrons and holes limits its antibacterial ability. Here, we describe a graphdiyne (GDY) composite TiO2 nanofiber that combats implant infections through enhanced photocatalysis and prolonged antibacterial ability. In addition, GDY-modified TiO2 nanofibers exert superior biocompatibility and osteoinductive abilities for cell adhesion and differentiation, thus contributing to the bone tissue regeneration process in drug-resistant bacteria-induced implant infection.

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Section: Discussionmentioning

confidence: 99%

Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

et al. 2020

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“…In addition, we have recently proved that GDY has a strong Kerr nonlinearity, [ 24 ] so it is expected to become an excellent NLO material for optical information converters, modulators, and optical switches. Chen et al found that GDY nanoflakes have high photothermal conversion ability, [ 61 ] so GDY can be coated on the surface of microfibers or silicon waveguides to develop into efficient thermo‐optic modulators, which opens a new way for the development of all‐optical devices. Finally, different morphologies of GDY (e.g., nanowalls, nanofilms, nanowires, nanotube arrays, and ordered stripe arrays) [ 1 ] have been fabricated and successfully applied in many fields such as energy storage, solar cells, catalysis, photoelectric devices.…”

Section: Resultsmentioning

confidence: 99%

Graphdiyne as a Promising Mid‐Infrared Nonlinear Optical Material for Ultrafast Photonics

Guo

Wang

Shi

et al. 2020

Advanced Optical Materials

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fascinating physical and chemical properties. At present, two dimensional (2D) materials with brilliant nonlinear optical (NLO) properties play an key role in modern photonics since the appearance of graphene. [15] However, GDY, as a 2D allotrope of graphene, is still in the primary stage of its application in photonic fields. [16,17] On the basis of previous research results, the advantages of GDY as a NLO material for photonic devices are obvious. First, it is essentially different from the zero-band gap of graphene. GDY has a tunable direct band gap of 0.46-1.10 eV (according to different simulated methods), [18][19][20] which shows that GDY has great potential in the application of photonic devices based on optical switch function. Besides, in the structure of GDY, the alkyne bonds and sub-nanopore, provide a large number of reaction sites for its functionalization. In this context, the optical energy gap of the original GDY can be tuned in a wide range of wavelengths by controlling the type and amount of doped atoms (e.g., boron, nitrogen, phosphorus, and sulfur), [21][22][23] which makes GDY a more compatible NLO material. Recently, we used the method of spatial self-phase modulation to demonstrate the strong broadband Kerr nonlinearity and large nonlinear refractive index (in the order of ≈10 −5 cm 2 W −1 ) of GDY, [24] which indicates that GDY can be widely used in multi-functional photonic devices. Compared with the unstable black phosphorus (BP), the GDY material can remain stable up to 1000 K and its service life at room temperature is extremely long. [25] The excellent stability of GDY prevents it from photooxidation and photo degradation under high strong light irradiation, which is of crucial significance for the development of photonic devices that can be used for a long term. In view of this, the research and development of advanced multifunctional photonics devices (e.g., detector, photonic diode, switcher, sensors, and modulator) based on GDY is not only of great significance to fully understand the optical performance of all-carbon nanomaterials, but also promotes the development of photonic devices based on 2D materials.Ultrafast lasers which can be passively generated using saturable absorption of 2D materials play a pivotal role in various cutting-edge technologies such as micromachining, [26] hyperfine medical surgery, [27] and ultrafast information processing. [28] However, up to now, most of the ultrashort pulse generation Graphdiyne (GDY) is a novel 2D all-carbon nanomaterial, which has an intransic band gap, strong light-matter interaction, and large optical absorption in the infrared region, indicating that it has great potential in the field of mid-infrared ultrafast photonics. Here, a Z-scan method is used to demonstrate the broadband and strong nonlinear optical (NLO) response of GDY, and its performance in the application of mid-infrared ultrafast photonics is explored for the first time. The experimental results demonstrate that its nonlinear parameters are superior to the current...

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“…The peak area of TPENH 2 reached 94.18% from HPLC analysis (see the Supporting Information for details). The chemical structure has been verified by 1…”

Section: Characterization Of Aie Molecule Tpenhmentioning

confidence: 99%

“…Cancer is a highly fatal disease which involves abnormal cell growth with the opportunity to move to and invade other parts of the body [1][2][3]. To date, chemotherapy has still remained the most commonly used therapeutic option for cancer treatment [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional nanogel engineering with redox-responsive and AIEgen features for the targeted delivery of doxorubicin hydrochloride with enhanced antitumor efficiency and real-time intracellular imaging

Zhou

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Nanogels exhibit potential application values in drug delivery systems because of their tunable properties and biocompatibility. In this study, multifunctional hyaluronic-based nanogels (HNPs), all-trans retinoid acid (ATRA)/aggregation-induced emission luminogen (AIEgen) fluorophores (TPENH 2)-grafted hyaluronic acid (HA) with disulfide bonds as linkers of (HA-ss-ATRA/TPENH 2), were successfully developed for doxorubicin hydrochloride (DOX) delivery. Besides, the controls of HA-ATRA/TPENH 2 were also developed for comparison. The HNPs with nanoscale particle sizes possessed an excellent DOX-loading capacity. As expected, the DOX-loaded HNPs exhibited the higher stability in a normal physiological environment (10 mM GSH), but rapidly disintegrated in the cancer microenvironment (20 mM GSH) according to an in vitro drug release study. The intracellular observation of HNPs by the fluorescence microscopy indicated that the self-fluorescent DOX-loaded HNPs with unique AIEgen characteristic transported DOX into the cancer cells and visibly accumulated within the cytoplasm. Importantly, the accumulation of DOX-loaded HNPs was largely increased due to the targeted reorganization of CD44 or LYCE-1 receptors by HA moieties on the surface of HNPs. Based on in vitro cytotoxicity analyses, the DOX-loaded HNPs displayed dramatically enhanced virulence to cancer cells compared to the controls and free DOX. This is the first study to achieve combined functionalities of targeted delivery, controllable release and real-time intracellular imaging on HA-base nanogels with enhanced antitumor efficiency. Therefore, the multifunctional HA-ss-ATRA/TPENH 2 HNPs have good potential to develop a novel drug delivery platform for the targeted delivery and controlled release of DOX to achieve enhanced antitumor efficiency as well as real-time intracellular imaging.

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Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemotherapy Combination Treatment of Cancer

Cited by 130 publications

References 35 publications

Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

Graphdiyne as a Promising Mid‐Infrared Nonlinear Optical Material for Ultrafast Photonics

Multifunctional nanogel engineering with redox-responsive and AIEgen features for the targeted delivery of doxorubicin hydrochloride with enhanced antitumor efficiency and real-time intracellular imaging

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