Grapefruit juice improves glucose intolerance in streptozotocin-induced diabetes by suppressing hepatic gluconeogenesis

Hayanga, Julia A.; Ngubane, Senelisiwe P.; Murunga, Alfred N.; Owira, Peter M. O.

doi:10.1007/s00394-015-0883-4

Cited by 17 publications

(11 citation statements)

References 24 publications

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“…These observations confirm that naringin reversed metabolic acidosis associated with DKA albeit in experimental animal model. We recently reported antidiabetic effects of grapefruit juice in experimental animal studies [ 30 ]. Naringin is the main flavonoid in grapefruit juice and therefore it seems plausible to infer that some of the antidiabetic effects of grapefruit juice could be attributed to naringin in addition to other as yet unidentified bioactive chemical ingredients.…”

Section: Discussionmentioning

confidence: 99%

Grapefruit Derived Flavonoid Naringin Improves Ketoacidosis and Lipid Peroxidation in Type 1 Diabetes Rat Model

et al. 2016

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BackgroundHypoglycemic effects of grapefruit juice are well known but the effects of naringin, its main flavonoid on glucose intolerance and metabolic complications in type 1 diabetes are not known.ObjectivesTo investigate the effects of naringin on glucose intolerance, oxidative stress and ketonemia in type 1 diabetic rats.MethodsSprague-Dawley rats divided into 5 groups (n = 7) were orally treated daily with 3.0 ml/kg body weight (BW)/day of distilled water (group 1) or 50 mg/kg BW of naringin (groups 2 and 4, respectively). Groups 3, 4 and 5 were given a single intra-peritoneal injection of 60 mg/kg BW of streptozotocin to induce diabetes. Group 3 was further treated with subcutaneous insulin (4.0 IU/kg BW) twice daily, respectively.ResultsStretozotocin (STZ) only-treated groups exhibited hyperglycemia, polydipsia, polyuria, weight loss, glucose intolerance, low fasting plasma insulin and reduced hepatic glycogen content compared to the control group. Furthermore they had significantly elevated Malondialdehyde (MDA), acetoacetate, β-hydroxybutyrate, anion gap and significantly reduced blood pH and plasma bicarbonate compared to the control group. Naringin treatment significantly improved Fasting Plasma Insulin (FPI), hepatic glycogen content, malondialdehyde, β-hydroxybutyrate, acetoacetate, bicarbonate, blood pH and anion gap but not Fasting Blood Glucose (FBG) compared to the STZ only-treated group.ConclusionsNaringin is not hypoglycemic but ameliorates ketoacidosis and oxidative stress. Naringin supplements could therefore mitigate complications of diabetic ketoacidosis.

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Section: Discussionmentioning

confidence: 99%

Grapefruit Derived Flavonoid Naringin Improves Ketoacidosis and Lipid Peroxidation in Type 1 Diabetes Rat Model

et al. 2016

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“…Furthermore, naringin treatment significantly improved glucose tolerance not only in normal but also in PI-exposed rats compared to the control and PI-treated rats, respectively ( Fig 4B ). Antihyperglycemic effects of naringin have previously been described [ 25 , 26 ]. In our study, naringin treatment significantly increased glucokinase protein content in both hepatic and pancreatic tissue compared to either controls or ATV- or SQV-treated animals, respectively ( Fig 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…Naringin is a flavanone derived from citrus species and has been demonstrated to possess antioxidant, anti-diabetic, anti-dyslipidemic and anti-inflammatory activities [ 22 – 24 ]. Hypoglycemic effects of naringin have previously been demonstrated [ 25 , 26 ]. We have recently reported that naringin improves both glucose intolerance and insulin resistance in non-diabetic rats [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Naringin prevents HIV-1 protease inhibitors-induced metabolic complications in vivo

2017

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BackgroundInsulin resistance, glucose intolerance and overt diabetes are known metabolic complications associated with chronic use of HIV-Protease Inhibitors. Naringin is a grapefruit-derived flavonoid with anti-diabetic, anti-dyslipidemia, anti-inflammatory and anti-oxidant activities.ObjectivesThe study investigated the protective effects of naringin on glucose intolerance and impaired insulin secretion and signaling in vivo.MethodsMale Wistar rats were divided into six groups (n = 6) and were daily orally treated with distilled water {3.0 ml/kg body weight (BW)}, atazanavir (133 mg/kg BW), saquinavir (333 mg/kg BW) with or without naringin (50 mg/kg BW), respectively for 56 days. Body weights and water consumption were recorded daily. Glucose tolerance tests were carried out on day 55 of the treatment and thereafter, the rats were sacrificed by halothane overdose.ResultsAtazanavir (ATV)- or saquinavir (SQV)-treated rats exhibited significant weight loss, polydipsia, elevated Fasting blood glucose (FBG), reduced Fasting Plasma Insulin (FPI) and expression of phosphorylated, Insulin Receptor Substrate-1 (IRS-1) and Akt proteins, hepatic and pancreatic glucokinase levels, and also increasing pancreatic caspase-3 and -9 as well as UCP2 protein expressions compared to controls, respectively. These effects were completely reversed by naringin treatment.ConclusionNaringin prevents PI-induced glucose intolerance and impairment of insulin signaling and as nutritional supplement it could therefore alleviate metabolic complications associated with antiretroviral therapy.

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“…Areca nut extract enriched with catechin‐based procyanidins reduced the level of hepatic G6Pase mRNA in STZ‐treated mice . Grapefruit juice has been reported to improve glucose intolerance in STZ‐treated rats by suppressing hepatic gluconeogenesis . Because azuki beans have previously been reported to be rich in proanthocyanidins as well as other catechins, it is possible that ABE treatment may suppress hepatic gluconeogenesis by reducing G6Pase protein expression via AMPK activation.…”

Section: Discussionmentioning

confidence: 99%

Azuki bean (Vigna angularis) extract stimulates the phosphorylation of AMP‐activated protein kinase in HepG2 cells and diabetic rat liver

et al. 2015

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Grapefruit juice improves glucose intolerance in streptozotocin-induced diabetes by suppressing hepatic gluconeogenesis

Abstract: These findings show that GFJ is not insulinotropic but improves glucose intolerance in diabetic rats by suppressing hepatic gluconeogenesis.

Cited by 17 publications

References 24 publications

Grapefruit Derived Flavonoid Naringin Improves Ketoacidosis and Lipid Peroxidation in Type 1 Diabetes Rat Model

Grapefruit Derived Flavonoid Naringin Improves Ketoacidosis and Lipid Peroxidation in Type 1 Diabetes Rat Model

Naringin prevents HIV-1 protease inhibitors-induced metabolic complications in vivo

Azuki bean (Vigna angularis) extract stimulates the phosphorylation of AMP‐activated protein kinase in HepG2 cells and diabetic rat liver

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