Grape skin extract reduces adipogenesis- and lipogenesis-related gene expression in 3T3-L1 adipocytes through the peroxisome proliferator-activated receptor-γ signaling pathway

Jeong, Yoo Seok; Hong, Joo Heon; Cho, Kyung Hyun; Jung, Hyun-Sam

doi:10.1016/j.nutres.2012.06.001

Cited by 29 publications

(26 citation statements)

References 37 publications

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“…Previous studies have focused on the mechanism of fatty deposits using rodents. For example, the rat 3T3-L1 cell line is usually used to study the differentiation of fat cells [32,33]. Moreover, fat mice are also considered as animal models to study fat metabolism diseases [34].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Zhang¹,

Huang²,

Guo³

et al. 2017

Oncotarget

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The domestic pig, an important species in the animal production industry, is also a model system for studying fat deposition and fat-associated diseases in humans. In order to investigate the genetic relationships of the miRNAs that may regulate fat deposition, we performed a genome-wide analysis of miRNAs derived from subcutaneous adipose tissue of Laiwu and Large White pig using RNA-seq. A total of 26,486,906 reads were obtained. Further analysis indicated that 39 known miRNAs and 56 novel miRNAs had significantly differential expression between the two breeds of pigs. Gene Ontology and KEGG pathway analysis revealed that the predicted targets of these differentially expressed miRNAs were involved in several fat-associated pathways, such as the PPAR, MAPK and Wnt signaling pathways. In addition, we found that three miRNAs, ssc-miR-133a-3p, ssc-miR-486 and ssc-miR-1, had an impact on the development of porcine subcutaneous fat through the PPAR signaling pathway. This study provides clues to understand the potential mechanisms of adipogenesis and fat deposition between two different pig breeds. Furthermore, these results may also contribute to the research involving human obesity.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Zhang¹,

Huang²,

Guo³

et al. 2017

Oncotarget

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“…Moreover, grape seeds may be separated from the pomace and used either for production of grape seed oil or as individual food supplements in the form of grape seed powder or grape seed extracts [41]. Additional flavonoids-rich products are also extracted from grape skins [42,43]. The North American grape species, such as M. rotundifolia (Michx.)…”

Section: Biological Activities Of Grape Productsmentioning

confidence: 99%

Recent Advances and Uses of Grape Flavonoids as Nutraceuticals

2014

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Grape is one of the oldest fruit crops domesticated by humans. The numerous uses of grape in making wine, beverages, jelly, and other products, has made it one of the most economically important plants worldwide. The complex phytochemistry of the berry is characterized by a wide variety of compounds, most of which have been demonstrated to have therapeutic or health promoting properties. Among them, flavonoids are the most abundant and widely studied, and have enjoyed greater attention among grape researchers in the last century. Recent studies have shown that the beneficial health effects promoted by consumption of grape and grape products are attributed to the unique mix of polyphenolic compounds. As the largest group of grape polyphenols, flavonoids are the main candidates considered to have biological properties, including but not limited to antioxidant, anti-inflammatory, anti-cancer, antimicrobial, antiviral, cardioprotective, neuroprotective, and hepatoprotective activities. Here, we discuss the recent scientific advances supporting the beneficial health qualities of grape and grape-derived products, mechanisms of their biological activity, bioavailability, and their uses as nutraceuticals. The advantages of modern plant cell based biotechnology as an alternative method for production of grape nutraceuticals and improvement of their health qualities are also discussed.

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“…Monomeric polyphenols such as apigenin [12] and epigallocatechin-3-O-gallate (EGCG) [13], resveratrol [14], curcumin [15], and polyphenolic extracts such as cocoa polyphenols extract and grape seed extract [3,16] were reported to inhibit 3T3-L1 adipocyte differentiation effectively through the suppression of PPARγ. It was reported that some polyphenols suppressed PPARγ expression in 3T3-L1 A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 4 cells by activating AMP-activated protein kinase (AMPK) [12], while some reports indicated that the expression of PPARγ was modified by several specific microRNAs ( miRNAs) such as miR-27a and miR-27b [17,18] .…”

Section: Introductionmentioning

confidence: 99%

A-type ECG and EGCG dimers disturb the structure of 3T3-L1 cell membrane and strongly inhibit its differentiation by targeting peroxisome proliferator-activated receptor γ with miR-27 involved mechanism

Zhu

Zou

Nie

et al. 2015

The Journal of Nutritional Biochemistry

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Grape skin extract reduces adipogenesis- and lipogenesis-related gene expression in 3T3-L1 adipocytes through the peroxisome proliferator-activated receptor-γ signaling pathway

Cited by 29 publications

References 37 publications

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Recent Advances and Uses of Grape Flavonoids as Nutraceuticals

A-type ECG and EGCG dimers disturb the structure of 3T3-L1 cell membrane and strongly inhibit its differentiation by targeting peroxisome proliferator-activated receptor γ with miR-27 involved mechanism

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