Grape skin and loquat leaf extracts and acai puree have potent anti-atherosclerotic and anti-diabetic activity in vitro and in vivo in hypercholesterolemic zebrafish

Kim, Jae-Yong; Hong, Joo-Heon; Jung, Hyun-Sam; Jeong, Yoo Seok; Cho, Kyung‐Hyun

doi:10.3892/ijmm.2012.1045

Cited by 44 publications

(26 citation statements)

References 41 publications

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“…Modern scientific studies using different experimental models have proved the anti-inflammatory capacity of different loquat tissues such as leaf [6,7,8,9,10], seed [11,12] and fruit [13]. …”

Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Liu

Zhang

et al. 2016

IJMS

122

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Loquat (Eriobotrya japonica Lindl.) is a subtropical fruit tree with high medicinal value native to China. Different organs of loquat have been used historically as folk medicines and this has been recorded in Chinese history for thousands of years. Research shows that loquat extracts contain many antioxidants, and different extracts exhibit bioactivity capable of counteracting inflammation, diabetes, cancer, bacterial infection, aging, pain, allergy and other health issues. Bioactive compounds such as phenolics and terpenoids have been isolated and characterized to provide a better understanding of the chemical mechanisms underlying the biological activities of loquat extracts. As the identification of compounds progresses, studies investigating the in vivo metabolism, bioavailability, and structure–activity relationships, as well as potential toxicity of loquat extracts in animal or cell models are receiving more attention. In addition, genetic studies and breeding of loquat germplasms for high contents of health-benefiting compounds may provide new insight for the loquat industry and research. This review is focused on the main medicinal properties reported and the possible pharmaceutically active compounds identified in different loquat extracts.

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Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Liu

Zhang

et al. 2016

IJMS

122

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“…Natural compound extracts of cinnamon, clove, grape skin, laurel, loquat, and turmeric contain inhibitors of zebrafish Cetp (30, 49, 50). These extracts protect zebrafish from high-cholesterol diet-induced dyslipidemia.…”

Section: Zebrafish Dyslipidemia Modelsmentioning

confidence: 99%

Zebrafish Models for Dyslipidemia and Atherosclerosis Research

Schlegel

2016

Front. Endocrinol.

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Atherosclerotic cardiovascular disease is the leading cause of death. Elevated circulating concentrations of lipids are a central pathogenetic driver of atherosclerosis. While numerous effective therapies for this condition have been developed, there is substantial unmet need for this pandemic illness. Here, I will review nutritional, physiological, genetic, and pathological discoveries in the emerging zebrafish model for studying dyslipidemia and atherosclerosis. The technical and physiological advantages and the pharmacological potential of this organism for discovery and validation of dyslipidemia and atherosclerosis targets are stressed through summary of recent findings. An emerging literature shows that zebrafish, through retention of a cetp ortholog gene and high sensitivity to ingestion of excess cholesterol, rapidly develops hypercholesterolemia, with a pattern of distribution of lipid species in lipoprotein particles similar to humans. Furthermore, recent studies leveraging the optical transparency of zebrafish larvae to monitor the fate of these ingested lipids have provided exciting insights to the development of dyslipidemia and atherosclerosis. Future directions for investigation are considered, with particular attention to the potential for in vivo cell biological study of atherosclerotic plaques.

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“…Angiogenic/anti-angiogenic Lam et al, 2008;He et al, 2009a;He et al, 2009b;Hong et al, 2009;He et al, 2010;Alex et al, 2010;KRILL et al, 2010;Zhu et al, 2011;Liu et al, 2011;Crawford et al, 2011;Tse et al, 2012;Zhong et al, 2012;He et al, 2012;Zhang et al, 2012;Han et al, 2012;Yu et al, 2013;Ba et al, 2013;Lee et al, 2013;Yahg et al, 2013;Fan et al, 2013;Yue et al, 2013, Da-Song et al, 2014Zhou et al, 2014;Germano et al, 2014Lai et al, 2015Antithrombotic activity Song et al, 2012Shi et al, 2015anticonvulsant Orellana-Paucar et al, 2012Buenafe et al, 2013;Challal et al, 2014Anti-inflammatory Kao et al, 2010Bohni et al, 2013;Wang et al, 2013Antilipemic Jin et al, 2011Kim et al, 2012;Pardal et al, 2014;Littleton et al, 2014Melanogenic Kim et al, 2008Ding et al, 2011;Park et al, 2013;Kim et al, 2014;Wang et al, 2014Neurodegenerative diseases Zhang 2012Chong et al, 2013;…”

Section: Activity Assayed In Zebrafish Model Referencesmentioning

confidence: 99%

Use of zebrafish (Danio rerio) in experimental models for biological assay with natural products

Santos¹,

Duarte²,

Fernandes³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Research on natural products is facing significant difficulty. The analysis "high-throughput screening" has limited effectiveness in their evaluation. This report on in vitro screening of pharmacological activity of the drugs candidate molecule by evaluating a single target. The presence of many substances in a natural extract makes this process unprecise. The zebrafish (Danio rerio, ZF) is well suited to highthroughput applications owing to its high fecundity, rapid extrauterine development and transparency during organogenesis. This fact promotes increase in the relevance of their use in biological assays, which is hard to be matched in vitro. Tests based on ZF can aid in the isolation of bioactive molecules from plant extracts, which was identified in a large-scale screening. This increases the biological relevance of such findings. Another decisive factor for the use of ZF as an experimental model, for widespread testing, is the few extracts or the isolated compounds required for tests. Therefore, the growing number of publications and innovative models created for the research shows a lot of diseases with this species, revealing the importance of ZF as an experimental model for the screening of natural products.

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Grape skin and loquat leaf extracts and acai puree have potent anti-atherosclerotic and anti-diabetic activity in vitro and in vivo in hypercholesterolemic zebrafish

Cited by 44 publications

References 41 publications

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Zebrafish Models for Dyslipidemia and Atherosclerosis Research

Use of zebrafish (Danio rerio) in experimental models for biological assay with natural products

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