Grape seed extract suppresses calcitonin gene-related peptide secretion and upregulates expression of GAD 65/67 and GABAB receptor in primary trigeminal ganglion cultures

Antonopoulos, Sophia R.; Durham, Paul L.

doi:10.1016/j.ibneur.2022.08.006

Cited by 7 publications

(3 citation statements)

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“…Notably, daily supplementation with coenzyme Q10 [92], curcumin [95] and vitamin D [96] were shown to reduce CGRP levels. Some other evidence derived from preclinical migraine and TMD model studies reported reduction of CGRP secretion with grape seed extract [97][98][99]. Table 3 summarizes the evidence of the efficacy and scientific rigor of the available human studies assessing nutritional supplements compared to a control group.…”

Section: Treatment Considerationsmentioning

confidence: 99%

Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches

Sangalli,

Eli,

Mehrotra

et al. 2023

IJMS

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A bidirectional causal relationship has been established between temporomandibular disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic pain offer a framework for understanding the comorbidity between these two conditions that might reside in the shared biomolecular mechanisms of peripheral and central sensitization. The initiation of these processes is inflammatory in nature and is most likely mediated by key molecules, including calcitonin gene-related peptide (CGRP). This scoping review proposes that CGRP-mediated neuroinflammation in the trigeminal ganglion may partly explain the biomolecular bidirectional link between TMDs and chronic headaches. Finally, clinical implications of this neuropathologic process are briefly discussed.

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Section: Treatment Considerationsmentioning

confidence: 99%

Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches

Sangalli,

Eli,

Mehrotra

et al. 2023

IJMS

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“…GABAB receptors are widely expressed in the central and peripheral nervous system exhibiting a development-and region-specific manner, including the thalamus, brainstem nuclei, and spinal cord and play a variety of important roles, such as synaptic development and memory [51]. The extensive expression of GABAB receptors in the pain sensing neurons in the superficial layers of the dorsal horn in the spinal cord and trigeminal ganglia suggests that it could be targetable for the modulation of analgesia [52]. For example, GABAB receptors in dorsal reticular nucleus in the spinal cord are involved in inflammatory pain [14].…”

Section: The Role Of Gabab Receptors In Pain Transduction and Modulationmentioning

confidence: 99%

GABA Receptor Subtypes Involvement of Analgesia: Current Status

Qian¹,

Zhao²,

Yu³

et al. 2023

Preprint

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Gamma-aminobutyric acid (GABA), a non-protein-producing amino acid, is extensively found in microorganisms, plants and vertebrates, and is abundantly expressed in the spinal cord and brain. To date, GABA is considered to be the major inhibitory neurotransmitter in the central nervous system. Its physiological effects are related to the regulation of synaptic transmission, the promotion of neuronal development and relaxation, and the prevention of insomnia and depres-sion. Mediated through its specific receptors, it plays a pivotal role in the control of neuronal ex-citability, which can serve as anovel target for developing analgesics for pain management. This review provides an update on the accumulating evidence of specific GABA receptors and their subtypes in the involvement of pain analgesia.

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“…The calcitonin gene-related peptide (CGRP) can be synthesized paracrinely by trigeminal neurons; the increase of this neuropeptide stimulates an inflammatory environment and increased nociceptive afferents [ 10 ]. OMT could improve the movement complex of the TMJ and, probably, stimulate the secretion of substances able to decrease the production of CGRP, increasing the GABAergic system [ 11 ]. OMT administered to patients with Parkinson's improves some neuromotor parameters; an explanation highlighted by the authors is that of having improved some cranial dysfunctions [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Osteopath’s Imprint: Osteopathic Medicine Under the Nanoscopic Lens

Bordoni¹,

Escher²

2023

Cureus

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Scientific literature demonstrates how osteopathic manipulative treatments (OMT) are able to improve various somatic functional parameters, change somato-visceral and viscero-somatic reflexes toward a more physiological mechano-metabolic environment and, consequently, bring benefits to patients. These benefits can be long-lasting or short-lived. Multiple reasons can be found to explain the positive responses to OMT, ranging from neurological, vascular, lymphatic, and endocrine explanations. Not only the techniques, but the touch of the clinician prove to be important factors for a favorable adaptation by the patient. Another science capable of explaining the change in cellular status and from which reflections that pave the way for observing the human body in a different light can be extrapolated is quantum physics. The latter is rarely taken into consideration to obtain possible explanations of the physical events that occur between the clinician and the patient. The article tries to put the effects of OMT under the light of a new lens: the nanoscopic.

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Grape seed extract suppresses calcitonin gene-related peptide secretion and upregulates expression of GAD 65/67 and GABAB receptor in primary trigeminal ganglion cultures

Cited by 7 publications

References 50 publications

Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches

Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches

GABA Receptor Subtypes Involvement of Analgesia: Current Status

The Osteopath’s Imprint: Osteopathic Medicine Under the Nanoscopic Lens

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