Grape seed extract: having a potential health benefits

Gupta, Manasvi; Dey, Sanjay; Marbaniang, Daphisha; Pal, Paulami; Ray, Subhashis; Mazumder, Bhaskar

doi:10.1007/s13197-019-04113-w

Cited by 114 publications

(84 citation statements)

References 63 publications

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“…In the present paper, we showed evidence that GSEe in vitro on HUVEC cells, widely utilized human-derived primary endothelial cells, produced a significant reduction of both sICAM and endothelin-1 secretion/release. Those effects, together with a significant activation of the vasodilating agent eNOS [ 31 ], support the beneficial effects of GSEe on vasodilatation and inflammation, as shown in other previous studies by proanthocyanidins [ 29 , 32 , 33 , 34 ]. The effect of GSEe on sVCAM appeared less clear, but since sVCAM is normally very low or not expressed in endothelial cells [ 33 ], it should be investigated better with other experiments such as inflammatory-induced models.…”

Section: Discussionsupporting

confidence: 84%

Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

et al. 2021

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It is well established that maintaining healthy blood pressure is fundamental in order to avoid disorders to the heart and blood vessels. In prevention, and alongside pharmacological therapy, the use of natural substances has been proven to be extremely helpful for pre- and mild hypertensive subjects. Our study was therefore focused on the effects, both in vitro and in humans, of a grape seed extract, Enovita (GSEe), a highly standardized extract in polyphenols of Vitis vinifera L. The in vitro human umbilical vein endothelial cells (HUVEC) model was chosen to explore the extract properties related to vascular inflammation/vasodilation. A significant reduction of both soluble Inter-Cellular Adhesion Molecule-1 (sICAM) and endothelin-1 secretion/release was induced by GSEe in HUVEC cells. A randomized, double-blind, placebo-controlled clinical study in healthy volunteers was further performed to investigate GSEe benefits. In healthy volunteers, both supplementations significantly modulated blood pressure, with a pronounced effect after GSEe tablets (300 mg/day for 16 weeks) in respect to placebo. In the male gender subgroup, no placebo effect was observed as it was for the female group. As an additional outcome, an overall GSEe positive modulation emerged on mood related to stress perception. Thus, GSEe resulted in a benefit of modulating endothelial functionality and blood pressure. It was noteworthy that GSEe relieved the perceived stress, promising new future perspectives on mood comfort.

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Section: Discussionsupporting

confidence: 84%

Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

et al. 2021

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“…In this sense, winery by-products have been successfully used to obtain antioxidant [ 31 ], antimicrobial [ 32 ], anti-inflammatory [ 33 ], antihyperglycemic [ 34 ], or antihypertensive compounds [ 14 , 16 , 17 , 35 ]. For instance, extracts rich in phenolic compounds (proanthocyanidins or resveratrol), with antihypertensive properties in both rats and humans, have been extracted from stem, grape seeds, or skin, respectively [ 13 , 15 , 16 , 17 , 36 , 37 , 38 ]. However, to our knowledge, no studies have been performed to evaluate whether WL can present ACEi or antihypertensive properties.…”

Section: Discussionmentioning

confidence: 99%

ACE Inhibitory and Antihypertensive Activities of Wine Lees and Relationship among Bioactivity and Phenolic Profile

López‐Fernández‐Sobrino

Soliz‐Rueda

Margalef

et al. 2021

Nutrients

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Wine lees (WL) are by-products generated in the winemaking process. The aim of this study was to investigate the angiotensin-converting enzyme inhibitory (ACEi) activity, and the blood pressure (BP) lowering effect of WL from individual grape varieties. The relationship among their activities and phenolic profiles was also studied. Three WL, from Cabernet, Mazuela, and Garnacha grape varieties, were firstly selected based on their ACEi properties. Their phenolic profiles were fully characterized by UHPLC-ESI-Q-TOF-MS. Then, their potential antihypertensive effects were evaluated in spontaneously hypertensive rats (SHR). BP was recorded before and after their oral administrations (2, 4, 6, 8, 24, and 48 h) at a dose of 5 mL/kg bw. Cabernet WL (CWL) exhibited a potent antihypertensive activity, similar to that obtained with the drug Captopril. This BP-lowering effect was related to the high amount of anthocyanins and flavanols present in these lees. In addition, a potential hypotensive effect of CWL was discarded in normotensive Wistar–Kyoto rats. Finally, the ACEi and antihypertensive activities of CWL coming from a different harvest were confirmed. Our results suggest the potential of CWL for controlling arterial BP, opening the door to commercial use within the wine industry.

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“…A mixture of α-tocopherol and α- and γ-tocotrienol purified from grape seeds was more effective than other lipophilic grape seed fractions in neutralizing free and lipid peroxy radicals and in chelating prooxidant metals [ 12 ]. Therefore, grape seed oil extract can be considered a valuable source of natural liposoluble antioxidants, having potential health benefits [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Innovative and Conventional Valorizations of Grape Seeds from Winery By-Products as Sustainable Source of Lipophilic Antioxidants

et al. 2020

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The aim of this study was to valorize the oil recovery from red and white grape seeds (Vitis vinifera L.) that remains as by-product after the winemaking process. Oils were extracted by modern techniques, ultrasound assisted (UAE), microwave assisted (MAE) and supercritical fluid extraction (SFE), and compared to the Soxhlet extraction (SE). Firstly, SFE was optimized at different operating conditions: pressure (250–350 bar), temperature (40–60 °C), CO2 flow rate (0.2, 0.3 and 0.4 kg h−1), and particle size (315–800 µm and >800 µm). The highest extraction yields were achieved by SFE at the optimal conditions: 350 bar, 60 °C, 0.4 kg h−1. Afterwards, SFE was compared to SE, UAE and MAE with respect to oil extraction yields, and analyzed for fatty acid composition and antioxidant capacity. Considering the general classification of fatty acids, it was found that samples had high content of polyunsaturated fatty acids, regardless of extraction technology. Tocopherol content was significantly influenced by all extraction methods, whereas UAE and MAE resulted in extracts richer with lipophilic antioxidants. In conclusion, modern extractions that are suited for industrial applications had better performance as compared to SE, as judging by the oil yield and quality.

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Grape seed extract: having a potential health benefits

Cited by 114 publications

References 63 publications

Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

ACE Inhibitory and Antihypertensive Activities of Wine Lees and Relationship among Bioactivity and Phenolic Profile

Innovative and Conventional Valorizations of Grape Seeds from Winery By-Products as Sustainable Source of Lipophilic Antioxidants

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