Grape seed extract as photochemopreventive agent against UVB-induced skin cancer

Perde-Schrepler, Maria; Cherecheș, Gabriela; Brie, Ioana; Tatomir, Corina; Postescu, I. D.; Soran, Loredana; Filip, Gabriela Adriana

doi:10.1016/j.jphotobiol.2012.10.008

Cited by 42 publications

(26 citation statements)

References 23 publications

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“…First, the ability of solar UVR to generate reactive free MDA was confirmed in both cultured human keratinocytes and normal human skin, a finding consistent with prior publications that reported MDA-generation in the context of photooxidative lipid damage [24, 49]. In cultured human skin cells, SSL exposure caused a dose-dependent increase in intracellular levels of free MDA that was observable at sublethal doses (60 mJ/cm 2 UVB; Fig.…”

Section: Discussionsupporting

confidence: 87%

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Williams

Bermudez

Park

et al. 2014

Journal of Photochemistry and Photobiology B: Biology

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Cutaneous exposure to solar ultraviolet radiation (UVR) is a causative factor in photoaging and photocarcinogenesis. In human skin, oxidative stress is widely considered a key mechanism underlying the detrimental effects of acute and chronic UVR exposure. The lipid peroxidation product malondialdehyde (MDA) accumulates in tissue under conditions of increased oxidative stress, and the occurrence of MDA-derived protein epitopes, including dihydropyridine-lysine (DHP), has recently been substantiated in human skin. Here we demonstrate for the first time that acute exposure to sub-apoptogenic doses of solar simulated UV light (SSL) causes the formation of free MDA and protein-bound MDA-derived epitopes in cultured human HaCaT keratinocytes and healthy human skin. Immunohistochemical staining revealed that acute exposure to SSL is sufficient to cause an almost twenty-fold increase in general MDA- and specific DHP-epitope content in human skin. When compared to dose-matched solar simulated UVA, complete SSL was more efficient generating both free MDA and MDA-derived epitopes. Subsequent tissue microarray (TMA) analysis revealed the prevalence of MDA- and DHP-epitopes in nonmelanoma skin cancer (NMSC). In squamous cell carcinoma tissue, both MDA- and DHP-epitopes were increased more than three-fold as compared to adjacent normal tissue. Taken together, these date demonstrate the occurrence of MDA-derived epitopes in both solar UVR-exposed healthy human skin and NMSC TMA tissue; however, the potential utility of these epitopes as novel biomarkers of cutaneous photodamage and a functional role in the process of skin photocarcinogenesis remain to be explored.

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Section: Discussionsupporting

confidence: 87%

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Williams

Bermudez

Park

et al. 2014

Journal of Photochemistry and Photobiology B: Biology

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“…Major antioxidative compounds in lotus leaf include hyperin, isoquercetin, astragalin, kaempferol, myricetin, and catechin (13). Most of the compounds that protect the skin from the toxicity of UVB come from plant extracts with high antioxidative effects (24,25). The antioxidative effects of lotus tea seems to come from the synergic effects of antioxidative compounds from the lotus seed and the products made from the Maillard reactions that occurs during the roasting process of the lotus seed.…”

Section: Discussionmentioning

confidence: 99%

Photoprotective Effect of Lotus (Nelumbo nucifera Gaertn.) Seed Tea against UVB Irradiation

Kim

Moon

2015

JFN

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Lotus (Nelumbo nucifera Gaertn.) seed is widely used as a traditional medicine in countries of Asia. Among many functions of the lotus seed, one interesting activity is its skin protection from the sunlight and scar. In this study, we focused on the skin protective property of lotus seed tea against ultraviolet B (UVB) irradiation. Two groups of a hairless mouse model, water as control (water group) and lotus seed tea (LST group), were administrated a fluid drink water for six months. After 6 month of administration, UVB exposure was carried out to both groups for another 3 months. During and after the administration, the skin moisture content and the morphological and histopathological analyses through biopsy were carried out. Prior to UVB irradiation, no significant difference was discovered in the skin moisture content for the water group and LST group (P＜0.05). However, drastic changes were observed after the UVB treatment. The LST group showed a clear evidence of skin protection compared to the control group (P＜0.05). The moisture content, epidermal and horny layer thickness, and protein carbonyl values all revealed that the intake of the lotus seed tea enhanced protection against UVB exposure. As a result, the long-term intake of the lotus seed tea showed the effect of preventing loss of skin moisture, mitigating the formation of abnormal keratinocytes, and contributing to protein oxidation inhibition.

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“…[14][15][16][17][18][19][20][21] Protective effects against UVB-induced phototoxicity are related to plant extracts which are rich in antioxidants. 22,23 The purpose of this study is to assess the inhibitory activity against UVB-induced phototoxicity and its underlying mechanisms of total phenylethanoid glycosides (TPG) and magnoloside I a (MI a ) from M. officinalis var. biloba fruits.…”

Section: 6mentioning

confidence: 99%

Total phenylethanoid glycosides and magnoloside I_afromMagnolia officinalisvar.bilobafruits inhibit ultraviolet B-induced phototoxicity and inflammation through MAPK/NF-κB signaling pathways

Chen

et al. 2018

RSC Adv.

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Magnolia officinalis var. biloba is used as a traditional medicine in China and as a food additive in the United Kingdom and the European Union. In this study, total phenylethanoid glycosides (TPG) and magnoloside I a (MI a ) from M. officinalis var. biloba fruits showed excellent radical scavenging activities and potent inhibition activities against ultraviolet B (UVB)-induced oxidative damage in vitro. In vivo, TPG and MI a inhibited UVBinduced skin phototoxicity in mice upon continuous irradiation for 10 days. Changes in the levels of malondialdehyde, catalase, glutathione peroxidase, superoxide dismutase, and hydroxyproline caused by UVB irradiation were remarkably reversed in a dose-dependent manner after treatment with TPG or MI a .Protein-level analysis further showed that compared with the UVB group, the TPG high-dose group or MI a group significantly down-regulated MAPK/NF-kB signaling pathways. Therefore, TPG and MI a possessed a powerful photoprotective property that can be applied in food and antiphototoxicity formulations.

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Grape seed extract as photochemopreventive agent against UVB-induced skin cancer

Cited by 42 publications

References 23 publications

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Photoprotective Effect of Lotus (Nelumbo nucifera Gaertn.) Seed Tea against UVB Irradiation

Total phenylethanoid glycosides and magnoloside I_afromMagnolia officinalisvar.bilobafruits inhibit ultraviolet B-induced phototoxicity and inflammation through MAPK/NF-κB signaling pathways

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Grape seed extract as photochemopreventive agent against UVB-induced skin cancer

Cited by 42 publications

References 23 publications

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Photoprotective Effect of Lotus (Nelumbo nucifera Gaertn.) Seed Tea against UVB Irradiation

Total phenylethanoid glycosides and magnoloside IafromMagnolia officinalisvar.bilobafruits inhibit ultraviolet B-induced phototoxicity and inflammation through MAPK/NF-κB signaling pathways

Contact Info

Product

Resources

About

Total phenylethanoid glycosides and magnoloside I_afromMagnolia officinalisvar.bilobafruits inhibit ultraviolet B-induced phototoxicity and inflammation through MAPK/NF-κB signaling pathways