Grape powder treatment prevents anxiety-like behavior in a rat model of aging

Patki, Gaurav; Ali, Quaisar; Pokkunuri, Indira; Asghar, Mohammad; Salim, Samina

doi:10.1016/j.nutres.2015.05.005

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…Fresh solution of 1.5% grape powder in tap water was made every day to feed the rats. This grape powder dose was carefully chosen after conducting pilot dose-response studies as the selected dosage showed most pronounced effects on oxidative stress and blood pressure in these rats [ 18 , 20 ].…”

Section: Methodsmentioning

confidence: 99%

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Grape Powder Improves Age‐Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats

Pokkunuri

Ali

Asghar

2016

Oxidative Medicine and Cellular Longevity

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We examined the effects and mechanism of grape powder- (GP-) mediated improvement, if any, on aging kidney function. Adult (3-month) and aged (21-month) Fischer 344 rats were treated without (controls) and with GP (1.5% in drinking water) and kidney parameters were measured. Control aged rats showed higher levels of proteinuria and urinary kidney injury molecule-1 (KIM-1), which decreased with GP treatment in these rats. Renal protein carbonyls (protein oxidation) and gp91phox-NADPH oxidase levels were high in control aged rats, suggesting oxidative stress burden in these rats. GP treatment in aged rats restored these parameters to the levels of adult rats. Moreover, glomerular filtration rate and sodium excretion were low in control aged rats suggesting compromised kidney function, which improved with GP treatment in aged rats. Interestingly, low renal mitochondrial respiration and ATP levels in control aged rats were associated with reduced levels of mitochondrial biogenesis marker MtTFA. Also, Nrf2 proteins levels were reduced in control aged rats. GP treatment increased levels of MtTFA and Nrf2 in aged rats. These results suggest that GP by potentially regulating Nrf2 improves aging mitochondrial and kidney functions.

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Section: Methodsmentioning

confidence: 99%

“…Grape powder [ 16 – 20 ] recently has received much attention with regard to its health benefits. However, whether grape powder has any beneficial effects on aging kidney and its impact on improving mitochondrial functions are not known.…”

Section: Introductionmentioning

confidence: 99%

Grape Powder Improves Age‐Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats

Pokkunuri

Ali

Asghar

2016

Oxidative Medicine and Cellular Longevity

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“…Grape intake is commonly considered to promote good health, and its effects have been associated with mental well-being ( Thomas et al, 2009 ; Wang et al, 2009 ; Vislocky and Fernandez, 2013 ). In particular, grapes’ antioxidant properties have been attributed predominantly to the content of numerous polyphenolic constituents, largely believed to be responsible for their beneficial effects ( Patki et al, 2015 ). However, anti-inflammatory and antiapoptotic mechanisms have also been proposed to explain protective effects ( Yousuf et al, 2009 ; Salim et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Double-Blinded, Clinical Trial on Effects of a Vitis vinifera Extract on Cognitive Function in Healthy Older Adults

Calapai

Bonina

Bonina³

et al. 2017

Front. Pharmacol.

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Introduction: Gradual population aging is creating a new set of needs in the general population. Memory capacity decreases with age, and memory deficits are considered an early symptom of Alzheimer’s Disease (AD), one of the most prevalent cognitive disorders in older people. Numerous studies have shown that grape polyphenolic compounds (GPs) are able to attenuate cognitive impairment and reduce brain lesions in experimental AD animal models. These GP effects are associated with improvement in brain antioxidant status and prevention of free radical-induced neuronal damage. We designed a randomized, double-blind, placebo-controlled clinical trial to investigate the potential beneficial effects of a Vitis vinifera-based dietary supplement on cognitive function and neuropsychological status in healthy older adults.Methods: One-hundred eleven subjects were recruited and randomly divided in two groups: one group received the V. vinifera-based dietary supplement Cognigrape® for 12 weeks (250 mg/day) and the second group received placebo over the same period of time. Before and after the end of the supplementation period, cognitive function and neuropsychological status were evaluated using the Mini-Mental State Examination (MMSE), Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HARS), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) evaluations.Results: MMSE scores were significantly improved after supplementation with Cognigrape® in comparison with baseline levels (p < 0.0001) and placebo (r = 0.59, 0.95% CI 0.11, 1.22; p < 0.0001). Cognigrape® supplementation produced a significant reduction in BDI (-15.8%) and HARS (-24.9%) scores with respect to baseline levels (p < 0.0001) and placebo (p < 0.0001 for BDI and p < 0.05 for HARS). RBANS total score was significantly improved by Cognigrape® with respect to baseline levels and placebo (r = 0.55, 0.95% CI 0.48, 6.07; p < 0.0001). The comparison with the placebo revealed improvements in several parameters among participants receiving Cognigrape®: attention (p < 0.001); language (p < 0.05); immediate memory (p < 0.0001); and delayed memory (p < 0.0001). Visuospatial/constructional abilities were not modified. During the study, no adverse effects were detected.Conclusion: The results show that 12 weeks of Cognigrape® supplementation is safe, can improve physiological cognitive profiles, and can concurrently ameliorate negative neuropsychological status in healthy older adults.

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“…Recent studies have shown that plant polyphenols possess a number of beneficial properties, such as reducing the risks of cancer and heart diseases (Mattera et al, 2017;Amor et al, 2018); green tea and grape powder have shown effect on alleviating cognitive impairments and leading to a lower prevalence of depressive symptoms (Mulero et al, 2015;Patki et al, 2015;Solank et al, 2015). It has been recognized that red wines are one of the richest sources of polyphenols and thus possess beneficial effects on human health when drunk in moderation (Nash et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

Yan

Sun

et al. 2019

Ciência Téc. Vitiv.

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The aim of this study was to investigate the antidepressant-like effect of red wine phenolic extracts in mouse model exposed to exogenous corticosterone. The results showed that 3-week corticosterone injections caused depression-like behavior in mice, as indicated by the significant decrease in sucrose consumption and increase immobility time in the forced swimming test (FST). Red wine phenolic extracts treatment significantly reduced serum corticosterone levels. Moreover, it was found that red wine phenolic extract increased the brain-derived neurotrophic factor protein (BNDF) and tropomyosin-related kinase B (TrkB) phosphorylation and cAMP-responsive element binding protein (CREB) phosphorylation levels in the hippocampus and prefrontal cortex. However, K252a, an inhibitor of TrkB, completely abolished those antidepressant-like effects. These results suggested that the red wine phenolic extracts produce an antidepressant-like effect in corticosteronetreated mice, at least in part, which is possibly mediated by modulating hypothalamic-pituitary-adrenal (HPA) axis, BDNF, TrkB and CREB phosphorylation levels in the brain region of mice.

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Grape powder treatment prevents anxiety-like behavior in a rat model of aging

Cited by 13 publications

References 35 publications

Grape Powder Improves Age‐Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats

Grape Powder Improves Age‐Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats

A Randomized, Double-Blinded, Clinical Trial on Effects of a Vitis vinifera Extract on Cognitive Function in Healthy Older Adults

Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

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