Granzyme B‐positive primary gastric T‐cell lymphoma: Gastric T‐cell lymphoma with the possibility of extrathymic T cell origin

Abstract

A case of primary gastric T-cell lymphoma, which was positive for granzyme B, is reported. The patient was a 47-year-old Japanese female who complained of a dull upper abdominal pain. Radiographic and endoscopic examinations revealed an ulcerative infiltrative lesion in her stomach. Following the confirmation of a high-grade malignant lymphoma, a distal gastrectomy with regional lymph nodal dissection was performed. The histology of the gastric lesion revealed a malignant lymphoma of the diffuse pleomorphic type without lymph nodal involvement. Immunohistochemistry revealed that the tumor cells were positive for LCA, CD3, TIA-1 and granzyme B, but were negative for CD4, CD8, CD56, CD30, L-26, EMA, TCR alpha/beta and TCR gamma/delta. Because the tumor cells showed T cell nature with cytotoxic activity proved by TIA-1 and granzyme B, and without evidence of further maturation of T cell, a malignant lymphoma originating from extrathymic-derived T cells was suggested.

Non‐HTLV‐1‐associated primary gastric T‐cell lymphomas show cytotoxic activity: clinicopathological, immunohistochemical characteristics and TIA‐1 expression in 31 cases

“…It is therefore possible that intraepithelial lymphocytes might be the origin of the gastric cytotoxic T‐cell lymphomas similar to the enteropathy‐associated T‐cell lymphoma. To our knowledge, only four studies have previously described primary gastric T‐cell lymphoma positive for granzyme B or TIA‐1, 20–23 and those cases showed no association with HTLV‐1. In the present study, eight cases were positive for TIA‐1, and two of these were positive for CD103.…”

“…Cytotoxic markers such as TIA‐1 and granzyme B could be demonstrated in these tumour cells by immunohistochemistry. On the other hand, few cases of the gastric T‐cell lymphoma show cytotoxic activity 20–23 . It is therefore possible that intraepithelial lymphocytes might be the origin of the gastric cytotoxic T‐cell lymphomas similar to the enteropathy‐associated T‐cell lymphoma.…”

“…On the other hand, few cases of the gastric T-cell lymphoma show cytotoxic activity. [20][21][22][23] It is therefore possible that intraepithelial lymphocytes might be the origin of the gastric cytotoxic T-cell lymphomas similar to the enteropathy-associated T-cell lymphoma. To our knowledge, only four studies have previously described primary gastric T-cell lymphoma positive for granzyme B or TIA-1, 20-23 and those cases showed no association with HTLV-1.…”

Frequent expression of CD30 antigen in the primary gastric non‐B, non‐Hodgkin lymphomas

“…In contrast to primary gastric B‐cell lymphomas, primary gastric T‐cell lymphomas are far more rare; fewer than 100 cases have been reported, most of which are from Japan 4–11 . In addition, these cases are frequently associated with adult T‐cell leukemia/lymphoma (ATLL) 7–11 .…”

Pathology service and practice: Solo‐practice pathologist in a community hospital in Japan: Personal experience and a proposal for cost‐ and time‐effective practice

“…Most of these presentations have been case reports. In addition, some reports have been published in academic journals 11–20 …”