Granzyme B is elevated in esophageal biopsies from children with eosinophilic esophagitis
Helena Thulin,
Jesper Säfholm,
Joachim Lundahl
et al.
Abstract:ObjectivesEosinophilic esophagitis (EoE) is an immune‐mediated antigen‐triggered inflammatory disease of the esophagus. Our aim was to investigate inflammatory responses by an ex vivo biopsy provocation‐based method, stimulating biopsies with milk, wheat, and egg extracts.MethodsAn experimental study was conducted on esophageal biopsies from children who underwent esophagogastroduodenoscopy. Supernatants were collected before and after stimulation of the biopsies with food extracts and analyzed for 45 differen… Show more
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