Granulosa cell tumour in two speyed bitches

Sivacolundhu, Ramesh K.; O’Hara, A.J.; Read, Roger W.

doi:10.1111/j.1751-0813.2001.tb14571.x

Cited by 19 publications

(35 citation statements)

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“…Interestingly, development of granulosa cell tumors has been reported in spayed bitches as in the present case [20,26]. One of them showed a predominance of lobules of luteallike cells accompanied by granulosa cells proliferating in a Sertoli cell pattern [26].…”

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confidence: 68%

“…The present case exhibited abnormal vaginal bleeding that is known to be the most frequent clinical manifestation of granulosa cell tumors and luteomas [26,[28][29][30]. Interestingly, development of granulosa cell tumors has been reported in spayed bitches as in the present case [20,26]. One of them showed a predominance of lobules of luteallike cells accompanied by granulosa cells proliferating in a Sertoli cell pattern [26].…”

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confidence: 81%

“…In dogs, there have been no case reports of ovarian luteomas except for one study of steroid cell tumor resembling luteoma associated with hyperadrenocortism in a bitch [29]. The present case exhibited abnormal vaginal bleeding that is known to be the most frequent clinical manifestation of granulosa cell tumors and luteomas [26,[28][29][30]. Interestingly, development of granulosa cell tumors has been reported in spayed bitches as in the present case [20,26].…”

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confidence: 94%

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A Case Resport of an Uncommon Sex-Cord Stromal Tumor Consisted of Luteal and Sertoli Cells in a Spayed Bitch

Ichimura

Shibutani

Mizukami

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. We report a rare case of benign sex cord-stromal tumor consisted largely of luteoma with minor portion of Sertoli cell tumor located at the position of the left ovary excision in an 11-year-old ovariectomized bitch. Granulosa cell component was lacking, and both luteal and Sertoli cell portions were entirely positive for inhibin  and neuron-specific enolase, whereas luteoma portion alone was positive for Wilms' tumor-1 (WT1), immunohistochemically. The results suggest that this tumor is a possible complication of incomplete ovarian excision at the time of ovariectomy and consisted of uncommon hybrid of luteal and Sertoli cells to be diagnosed as an unclassified sex cord-stromal tumor if applied in human cases. WT1-expression pattern suggested the signature of the difference in the phenotype of these cell types.KEY WORDS: inhibin , luteoma, Sertoli cell tumor, sex cord-stromal tumor, Wilms' tumor-1 (WT1).J. Vet. Med. Sci. 72(2): 229-234, 2010 In the old literature, a variety of types of sex cord-stromal tumors have been reported in bitches, such as granulosa cell tumor, Sertoli cell tumor, luteoma, and nonspecific stromal tumor [2,6,16]. In a later published retrospective study of 71 primary ovarian tumors in dogs, the incidence of epithelial tumors (46%) was slightly higher than that of sex cordstromal tumors (34%) or germ cell tumors (20%) [19]. Sex cord-stromal tumors were then equally divided into SertoliLeydig and granulosa cell tumors, and there was no indication of steroid cell tumors or luteomas. Granulosa cell tumors are usually the group of tumors that include granulosa theca cell tumors, and if they have abundance of lipid, they are diagnosed as luteinized granulosa cell tumors [30]. On the other hand, in humans, occasional tumors are encountered which clearly fall in the sex cord-stromal category but do not lend themselves to placement in the more specific categories, warranting the somewhat unsatisfactory diagnosis of sex cord-stromal tumor unclassified in both male and female gonads [25].This report describes a case of sex cord-stromal tumor with differentiation into luteal and Sertoli cells in an 11-year-old spayed bitch. At one year of age, this dog received ovariectomy for sterilization. At 10 years of age, bloody fluid appeared from valva. By ecography, one splenic tumor and another tumor located at the portion of the excised left ovary attached to the mesovaria were found, and they were then surgically resected. No other abdominal tumors/nodules were found at the surgery. The splenic tumor was histopathologically diagnosed as follicular lymphoma. The ovarian portion tumor consisted of a spherical and soft mass showing white and brown patchy pattern on cut surface. The mass was fixed in 10% neutral buffered formalin for three days at room temperature, trimmed, dehydrated, and paraffin embedded, and 4 m sections were stained with hematoxylin and eosin (HE). As immunohistochemical analyses, avidin-biotin-peroxidase complex (ABC) technique was applied using antibodies against inhibi...

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A Case Resport of an Uncommon Sex-Cord Stromal Tumor Consisted of Luteal and Sertoli Cells in a Spayed Bitch

Ichimura

Shibutani

Mizukami

et al. 2010

The Journal of Veterinary Medical Science

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“…This type of tumour is the second most frequent ovarian tumour in bitches, has multifactorial aetiology and 20% of cases exhibit metastasis. Sivacolundhu et al (2001) reported that GCTs are uncommon in bitches, and are rare in spayed bitches. In this last case, similarly to the case reported here, it can be suggested that the granulosa cell tumour was associated with the incomplete ovarian excision at the time of ovariohysterectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, surgical intervention can lead to disease associated with reproductive tissue which was properly removed. Granulosa cell tumours, pyometra, mammary tumours and other diseases associated with the release of steroid hormones from ovary remnants have all been linked with improper removal of reproductive tissue (Sivacolundhu et al 2001;Ragni 2005;Christensen et al 2013). Some reports have described the presence of uterine and ovarian remnants in bitches after ovariohysterectomy (Ball et al 2010), usually linked to pyometra.…”

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Uterine and ovarian remnants in an incorrectly spayed bitch: a case report

Marı́n¹,

Molina²,

Vizuete³

et al. 2014

Vet. Med. - Czech

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ABSTRACT:A spayed Samoyed bitch, 12 years old, was presented to the Veterinary Clinical Hospital of the University of Cordoba (Spain) with abundant vulvar sanguineous discharge over the previous three days. The clinical examination revealed a remarkable vulvar mass, which protruded through the vulvar lips. Abdominal ultrasonography revealed the presence of structures compatible with uterus and ovary, which had been presumably removed eight years previously. An exploratory laparotomy was carried out, which confirmed the presence of the right ovary and a remnant of the uterus. The histological evaluation confirmed a granulosa cell tumour in the ovary, and an enlarged portion of the right uterine horn with brownish contents. The vulvar mass was also surgically removed and fibroma with some fibrosarcoma areas was diagnosed. This case shows the evolution of ovary and uterus into the abdomen, which were incorrectly removed after ovariohysterectomy eight years previously.

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Testes, Ovaries, and Prostate

Conrado¹,

Henderson²

2020

Veterinary Cytology

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Granulosa cell tumour in two speyed bitches

Cited by 19 publications

References 10 publications

A Case Resport of an Uncommon Sex-Cord Stromal Tumor Consisted of Luteal and Sertoli Cells in a Spayed Bitch

A Case Resport of an Uncommon Sex-Cord Stromal Tumor Consisted of Luteal and Sertoli Cells in a Spayed Bitch

Uterine and ovarian remnants in an incorrectly spayed bitch: a case report

Testes, Ovaries, and Prostate

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