Granulosa Cell Tumors of the Equine Ovary

McCue, Patrick M.; Roser, Janet F.; Munro, Coralie; Liu, Irwin K. M.; Lasley, Bill L.

doi:10.1016/j.cveq.2006.08.008

Cited by 96 publications

(143 citation statements)

References 44 publications

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“…This type of cancer is also the most common ovarian cancer in other mammals, such as the mare, and appears spontaneously in certain strains of mice (Beamer et al 1985, McCue et al 2006. These tumours can cause hyperoestrogenism, resulting in various symptoms such as disturbance of menstruation or uterine bleeding after menopause (Tavassoli et al 2003).…”

Section: Foxl2: a Key Player In Gc Proliferation And Tumorigenesismentioning

confidence: 99%

FOXL2: a central transcription factor of the ovary

Georges¹,

Auguste²,

Bessière³

et al. 2013

Journal of Molecular Endocrinology

134

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Forkhead box L2 (FOXL2) is a gene encoding a forkhead transcription factor preferentially expressed in the ovary, the eyelids and the pituitary gland. Its germline mutations are responsible for the blepharophimosis ptosis epicanthus inversus syndrome, which includes eyelid and mild craniofacial defects associated with primary ovarian insufficiency. Recent studies have shown the involvement of FOXL2 in virtually all stages of ovarian development and function, as well as in granulosa cell (GC)-related pathologies. A central role of FOXL2 is the lifetime maintenance of GC identity through the repression of testis-specific genes. Recently, a highly recurrent somatic FOXL2 mutation leading to the p.C134W subtitution has been linked to the development of GC tumours in the adult, which account for up to 5% of ovarian malignancies. In this review, we summarise data on FOXL2 modulators, targets, partners and post-translational modifications. Despite the progresses made thus far, a better understanding of the impact of FOXL2 mutations and of the molecular aspects of its function is required to rationalise its implication in various pathophysiological processes.

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Section: Foxl2: a Key Player In Gc Proliferation And Tumorigenesismentioning

confidence: 99%

FOXL2: a central transcription factor of the ovary

Georges¹,

Auguste²,

Bessière³

et al. 2013

Journal of Molecular Endocrinology

134

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“…The GTCT is a sex cord gonadal-stromal tumour, involving granulosa and theca cells in varying proportions. Some authors refer to the same class of tumours as granulosa cell tumours (McCue et al 2006). For this report the term GTCT is used.…”

Section: Introductionmentioning

confidence: 99%

“…Classically, the mare presents with a history of behavioural changes or anoestrus, and rectal palpation and transrectal ultrasonography reveals one enlarged ovary with a small and inactive contralateral ovary, and a presumptive diagnosis of GTCT is made. GTCT are steroidogenically competent, so profiles of concentrations of inhibin, testosterone and progesterone in blood may be assessed in mares with presumptive GTCT, to support the diagnosis (Bailey et al 2002;McCue et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Granulosa theca cell tumour in a pregnant mare: concentrations of inhibin and testosterone in serum before and after surgery

Gee

Dicken

Archer

et al. 2012

New Zealand Veterinary Journal

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“…Surgical removal of GCTs is the only solution available for treatment of the typical presentation of aggressive, stallionlike or nymphomania behaviour, infertility and anoestrous (McCue et al 2006;Sherlock et al 2016). Laparotomy (Crabtree 2011) and laparoscopy have both been reported for surgical removal of large, nonruptured GCTs (Rodgerson et al 2002;de Bont et al 2010).…”

Section: Treatment Optionsmentioning

confidence: 99%

“…Ovarian tumours account for 2.5% of all neoplasms in the horse (Sundberg et al 1977) and granulosa cell tumour (GCT) is the most common neoplasm affecting the equine ovary (McCue et al 2006). The most common clinical signs associated with ovarian GCTs are changes in behaviour, specifically developing aggressive, stallion-like or nymphomania behaviour, infertility, anoestrous or colic (Crabtree 2011).…”

Section: Introductionmentioning

confidence: 99%

Treatment of haemoperitoneum secondary to ruptured granulosa cell tumours in two mares

Worsman

Barakzai²,

Bont

et al. 2018

Equine Veterinary Education

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SummaryThis report describes two cases of successful surgical management of granulosa cell tumours (GCT) in mares presenting with haemoperitoneum (HP). Controlled abdominal drainage was initially attempted in Case 1 but was not successful. A ventral midline exploratory laparotomy allowed removal of a haemorrhaging 13 kg GCT. The mare made a full recovery and returned to normal work as a driving pony 11 months post-operatively. In Case 2 controlled abdominal drainage was followed by standing left flank laparoscopic visualisation of the bleeding ovary and transection of the ovarian pedicle by electrocautery. The GCT was then removed via a ventral midline incision due to its large size. Haemoperitoneum can be associated with GCTs and in some cases is severe enough to prompt emergency treatment. Stabilisation of the patient and removal of the haemorrhaging GCT can lead to a successful outcome.

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Granulosa Cell Tumors of the Equine Ovary

Cited by 96 publications

References 44 publications

FOXL2: a central transcription factor of the ovary

FOXL2: a central transcription factor of the ovary

Granulosa theca cell tumour in a pregnant mare: concentrations of inhibin and testosterone in serum before and after surgery

Treatment of haemoperitoneum secondary to ruptured granulosa cell tumours in two mares

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