Granulosa Cell Tumors: Novel Predictors of Recurrence in Early-stage Patients

Sakr, Sharif; Abdulfatah, Eman; Thomas, Sumi; Al-Wahab, Zaid; Beydoun, Rafic; Morris, Robert T.; Ali-Fehmi, Rouba; Bandyopadhyay, Sudeshna

doi:10.1097/pgp.0000000000000325

Cited by 21 publications

(10 citation statements)

References 65 publications

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“…Also, GCT recurrence remains largely unpredictable, although this risk may be increased by factors such as patient's age, tumor size >10 to >15 cm, intraoperative tumor rupture and genetic [ [16] , [17] , [18] ]. Recurrences after therapy have typically occurred within 5 to 10 years [ 19 ]. Therefore, we suggest following up every 3 months in endocrine clinic about regression of puberty signs and symptoms and at least every 6 months laboratory tests and pelvic ultrasound be done.…”

Section: Discussionmentioning

confidence: 99%

Vaginal bleeding imitated rape in a 6-year old girl, a case report about granulosa cell tumor as a reason of peripheral precocious puberty

Amirkashani,

Nasiri,

Dadakhani

et al. 2024

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Vaginal bleeding imitated rape in a 6-year old girl, a case report about granulosa cell tumor as a reason of peripheral precocious puberty

Amirkashani,

Nasiri,

Dadakhani

et al. 2024

International Journal of Surgery Case Reports

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“…Sakr et al [ 44 ] evaluated novel predictors of recurrence in GCTs from a single institution cohort of 125 case between 1975 and 2014, found for early-stage (stage I) aGCTs, high expression of SMAD3 was a independent predictors of recurrence.…”

Section: Discussionmentioning

confidence: 99%

Can adjuvant chemotherapy improve the prognosis of adult ovarian granulosa cell tumors?

et al. 2022

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Adult granulosa cell tumors (aGCTs) are rare ovarian neoplasms with a relatively favorable prognosis. They follow an indolent course, characterized by a prolonged natural history and a tendency to late recurrences, Around a quarter of patients develop recurrence and More than 70% of women with recurrence die from their disease, The percentage of patients received chemotherapy increases over time, whether adjuvant chemotherapy improve the prognosis of aGCTs is equivocal? The purpose of this review is to summarize the previously published evidence to evaluate whether adjuvant chemotherapy improve the prognosis of aGCTs to provide guidance for clinical practice. EMBASE, PubMed, Web of Science, WanFang Data and Chinese National Knowledge Infrastructure are searched up to December 2020, used the search strategy of ovar * and granulosa cell * and (tumor * or tumour * or malignan * or cancer * or carcinom * or neoplasm * ) and chemotherapy. The screening process was conducted strictly based on inclusion and exclusion criteria. Clinical studies based on human including randomized controlled trial, quasi-randomised controlled trials, nonrandomised trials cohort study and case control study were included without restriction of time. The percentage of patients received chemotherapy increases over time, but the benefit of adjuvant chemotherapy is lack of high-grade evidence of prospective study, based on the current retrospective studies, we still do not have the evidence to confirm the survival benefit of adjuvant chemotherapy in early stage, advanced stage or recurrent aGCT with no residual tumor, but for inoperable disseminated disease or disease with suboptimal cytoreduction, adjuvant chemotherapy maybe an Optable options. Multinational prospective randomised controlled trials are urgently needed to validate the role of adjuvant chemotherapy. Further research on molecular mechanisms and developing novel targeted medicines may improve the survival of aGCTs.Abbreviations: ACG = adjuvant chemotherapy group, aGCTs = adult granulosa cell tumors, BEP = bleomycin, etoposide, and cisplatin, CR = complete response, DFS = disease-free survival, FIGO = Federation International of Gynecology and Obstetrics, FOXL2 = fork head box protein L2, GCTs = granulosa cell tumors, GOG = Gynecologic Oncology Group, KMT2D = histone-lysine Nmethyltransferase 2D, HER = human epidermal growth factor receptors, NCCN = National Comprehensive Cancer Network, OS = overall survival, PFS = progression-free survival, PR = partial response, PVB = cisplatin, vinblastine, and bleomycin, RCTs = randomized controlled trials, TERT = telomerase reverse transcriptase, TP53 = tumor protein p53.

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“…It was reported that a high expression of CD56 or SMAD3 showed a significant prediction of recurrence. 16 It was recently reported that recurrence may be detected noninvasively from circulating plasma cell free DNA in patients with clinical disease via a liquid biopsy for the FOXL2 mutation. 17 …”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging of Recurrent Adult Granulosa Cell Tumor of the Ovary: A Retrospective Analysis of 11 Cases

Matsuki¹,

Numoto²,

Suzuki³

et al. 2020

J Comput Assist Tomogr

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Objective The aim of the study was to characterize magnetic resonance imaging findings in patients with recurrent ovarian adult granulosa cell tumors (AGCTs). Methods Clinical and magnetic resonance imaging manifestations of recurrent AGCTs were evaluated in 11 patients. Results Initial recurrences of AGCT were diagnosed between 13 months and 30 years (mean, 11.3 years). Recurrent tumors were located in the pelvic peritoneum, the abdominal peritoneum, the retroperitoneum, and bone. The number of recurrent tumors varied from 1 to 5. Tumors varied in morphology and all margins were well circumscribed. The internal structures noted were as follows: multilocular cystic and solid and cystic. Furthermore, internal hemorrhage and sponge-like multicystic components were identified. Conclusions Ovarian AGCTs recurred in the pelvic peritoneum, abdominal peritoneum, and the retroperitoneal lymph nodes. Large recurrent AGCTs were commonly well circumscribed, round or lobulated, and multilocular cystic or solid and cystic. Moreover, they frequently included internal hemorrhage and sponge-like multicystic components.

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Granulosa Cell Tumors: Novel Predictors of Recurrence in Early-stage Patients

Cited by 21 publications

References 65 publications

Vaginal bleeding imitated rape in a 6-year old girl, a case report about granulosa cell tumor as a reason of peripheral precocious puberty

Vaginal bleeding imitated rape in a 6-year old girl, a case report about granulosa cell tumor as a reason of peripheral precocious puberty

Can adjuvant chemotherapy improve the prognosis of adult ovarian granulosa cell tumors?

Magnetic Resonance Imaging of Recurrent Adult Granulosa Cell Tumor of the Ovary: A Retrospective Analysis of 11 Cases

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