Granulosa cell tumors in Israel: A study of 172 cases

Ohel, Gonen; Kaneti, Hagai; Schenker, Joseph G.

doi:10.1016/0090-8258(83)90083-5

Cited by 117 publications

(98 citation statements)

References 14 publications

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“…Tumoral estrogen secretion can cause uterine enlargement and endometrial thickening. 40% of the adult forms are associated with endometrial hyperplasia and 10% is associated with endometrial adenocarcinoma, so some authors suggested that a preoperative endometrial sampling is required (Ohel et al, 1983;Chua et al, 2001). In our study we found that abnormal uterine bleeding is the most common presenting symptom, and also serum estradiol levels were higher in GCTO group, but the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Parameters for Predicting Granulosa Cell Tumor of the Ovary: A Single Center Retrospective Comparative Study

Yeşilyurt¹,

Tokmak²,

Güzel³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: To evaluate factors for predicting the granulosa cell tumor of the ovary (GCTO) pre-operatively. Materials and Methods: This retrospective designed study was conducted on 34 women with GCTO as the study group and 76 women with benign ovarian cysts as the control group. Data were recorded from the hospital database and included age, body mass index (BMI), parity, serum estradiol (E 2 ) levels, diameter of the mass, ultrasonographic features, serum CA125 level, risk of malignancy index (RMI), duration of menopause, postoperative histopathology result, and the neutrophil/lymphocyte ratio (NLR). Results: The demographic parameters showed no statistically significant difference between the groups. Preoperative diameter of the mass, CA125, duration of menopause, and neutrophil/lymphocyte ratio were significantly different between the groups. ROC curve analysis demonstrated that diameter of the mass, serum estradiol and Ca125 levels, RMI and NLR may be discriminative factors in predicting GCTO preoperatively. Conclusions: In conclusion, we think that a careful preoperative workshop including diameter of the mass, serum estradiol (E 2 ) and Ca125 levels, RMI and NLR may predict GCTO and may prevent incomplete approaches.

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Section: Discussionmentioning

confidence: 99%

Parameters for Predicting Granulosa Cell Tumor of the Ovary: A Single Center Retrospective Comparative Study

Yeşilyurt¹,

Tokmak²,

Güzel³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…11 The incidence of tumor in women of European and American background was almost twice that of women of African and Asian origin, 0.98 versus 0.522/100 000/y. The reported incidence of granulosa cell tumor has varied from 0.58 to 1.6/100 000/y 10,11,15 and was reported as 0.62/100 000/y in Finland. 11 In United States the calculated incidence for white females is 0.99/100 000/y.…”

Section: Epidemiologymentioning

confidence: 99%

“…[1][2][3][10][11][12][13][14][15] During a 15-year period in Israel, 172 new cases of this tumor were diagnosed, for an incidence of 0.9 cases per 100 000 women per year. 11 The incidence of tumor in women of European and American background was almost twice that of women of African and Asian origin, 0.98 versus 0.522/100 000/y. The reported incidence of granulosa cell tumor has varied from 0.58 to 1.6/100 000/y 10,11,15 and was reported as 0.62/100 000/y in Finland.…”

Section: Epidemiologymentioning

confidence: 99%

Granulosa Cell Tumor of the Ovary: Tumor Review

et al. 2008

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Granulosa cell tumors of the ovary are rare neoplasms that originate from sex-cord stromal cells. The long natural history of granulosa cell tumors and their tendency to recur years after the initial diagnosis are the most prominent of their characteristics. The secretion of estradiol is the reason for signs at presentation such as vaginal bleeding and precocious puberty. Abdominal pain and hemoperitoneum, which occasionally can occur, are attributable to tumor rupture. The most common finding in pelvic examination is a tumor mass, which is subsequently confirmed with imaging techniques. Surgery is the mainstay of initial management for histological diagnosis, appropriate staging, and debulking. A more conservative unilateral salpingo-oophorectomy is indicated in patients with stage I disease and patients of reproductive age. Total abdominal hysterectomy with bilateral salpingo-oophorectomy is the appropriate surgical treatment for postmenopausal women and those with more advanced disease. The stage of disease is the most important prognostic factor associated with the risk of relapse. There are no clear conclusions regarding the role of postoperative chemotherapy or radiotherapy in stage I disease and in those with completely resected tumor. The use of adjuvant chemotherapy or radiotherapy has sometimes been associated with prolonged disease-free survival and possibly overall survival. Chemotherapy is the treatment of choice for patients with advanced, recurrent, or metastatic disease, and BEP (bleomycin, etoposide, and cisplatin) is the preferred regimen. Although the overall rate of response to treatment is high, the impact of treatment on disease-free or overall survival is unknown. Prolonged surveillance is mandatory because tumors tend to recur years after the initial diagnosis.

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“…Uterine cancer is nearly always a low-grade, low-stage endometrioid adenocarcinoma (35). Moreover, women with GCT have a higher risk of breast cancer development (36,37). Unregulated inhibin production can cause infertility, and androgen secretion may induce virilizing symptoms in a small group of patients (31,32).…”

Section: Pure Sex Cord Tumors Adult and Juvenile Granulosa Cell Tumorsmentioning

confidence: 99%

Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists

Horta

Cunha

2015

Diagn Interv Radiol

115

108

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Granulosa cell tumors in Israel: A study of 172 cases

Cited by 117 publications

References 14 publications

Parameters for Predicting Granulosa Cell Tumor of the Ovary: A Single Center Retrospective Comparative Study

Parameters for Predicting Granulosa Cell Tumor of the Ovary: A Single Center Retrospective Comparative Study

Granulosa Cell Tumor of the Ovary: Tumor Review

Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists

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