Granulosa-Cell Tumor of Ovary with Sexual Precocity

WITHIN RECENT years granulosa\x=req-\ theca-cell tumors have attracted much interest, primarily because of their hormonal function. These tumors are the principal feminizing neoplasms of the ovary; and it has been emphasized that when they occur in prepubertal females, they almost always cause sexual precocity. Because of this known and rather constant relationship, the diagnosis of granulosa-theca-cell tumor usually is entertained in the differential diagnosis of isosexual precocity in females. Although it is appropriate that some consideration should be given to this diagnosis in all such patients, it should be remembered that not more than 10% of cases of sexual precocity in the female arise from ovarian tumors.The purpose of this article is to review the literature on this interesting problem, especially as it relates to children, and to emphasize the pitfalls in making the diagnosis. IncidenceThe rarity of granulosa-theca-cell tumors of the ovary is appreciated if it is remembered that primary ovarian tumors are rare, and that of these the granulosatheca-cell variety constitute only about

show abstract

An Association of Hypothalamic Hamartoma, Central Precocious Puberty and Juvenile Granulosa Cell Tumour in Early Childhood

Jørgensen

Jacobsen²,

Ahrons³

et al. 1998

Horm Res Paediatr

View full text Add to dashboard Cite

A case of central precocious puberty from infancy due to a hypothalamic hamartoma and associated with an ovarian juvenile granulosa cell tumour is presented. Central precocious puberty was diagnosed by gonadotropin stimulation tests and LHRH agonist therapy was successful. A MR scan, but not a CT scan, demonstrated the hypothalamic hamartoma. The possible influence of early LH stimulation for the development of the granulosa cell tumour is discussed.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Granulosa-Cell Tumor of Ovary with Sexual Precocity

Cited by 3 publications

References 6 publications

Precocious Pseudopuberty Due to Granulosa Cell Tumor in Three Girls

Precocious Pseudopuberty Due to Granulosa Cell Tumor in Three Girls

Granulosa-Theca-Cell Tumor of the Ovary in Children

An Association of Hypothalamic Hamartoma, Central Precocious Puberty and Juvenile Granulosa Cell Tumour in Early Childhood

Contact Info

Product

Resources

About