Granulomatous uveitis and choroidal detachment in a patient after topical treatment with Bimatoprost: A case report

Abstract

Background: Bimatoprost 0.03% is an intraocular pressure (IOP) lowering prostaglandin analog with different adverse side effects such as potential ocular inflammatory effect and ocular hyperemia. Case presentation: We report a case of 80-year-old woman diagnosed with bilateral glaucomatous uveitis, and choroidal detachment in the left eye after topical bimatoprost administration. During the patient’s hospitalization, Bimatoprost treatment was discontinued and local steroid therapy was administrated. After 1 week we reported a marked improvement of visual acuity, IOP measurement was 12 mmHg in both eyes. Anterior segment examination showed complete resolution of conjunctival and pericheratic hyperemia with significant reduction of endothelial precipitates in both eyes. Conclusions: In our case, the anterior granulomatous uveitis occurred in both pseudophakic eyes and the choroidal detachment (CD) in the eye that previously had trabeculectomy. Probably the scar tissue of the trabeculectomy allowed a better penetration of the Bimatoprost or a greater sensitivity due to an altered trabecular tissue. This work confirms that the onset physiopathology mechanism of granulomatous uveitis and CD following instillation of Bimatoprost remains uncertain.

Drugs Causing Uveitis: Pathogenesis, Diagnosis and Treatment

“…PG analoglarına bağlı gelişen üveit genellikle ön kamarada sınırlı, non-granülomatöz reaksiyon şeklinde olmakla birlikte, literatürde yoğun granülomatöz üveit eşliğinde posterior sineşi ve hatta koroid dekolmanı bildiren yayınlar da mevcuttur. [103,104]…”