Granulomatous tattoo reactions in permanent makeup of the eyebrows

Huisman, Sanne; Bent, S A S van der; Wolkerstorfer, Albert; Rustemeyer, Thomas

doi:10.1111/jocd.12540

Cited by 25 publications

(24 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although signs of cutaneous or systemic sarcoidosis were absent, it cannot be ruled out that sarcoidosis will develop later in these patients. 36 A further study with more focus on immunohistochemical analyses may give an additional insight on these red tattoo reactions. We are planning to perform these studies, together with electron microscopic studies of the tattoo pigment particles and lymphoid cells that we observed on apoptotic keratinocytes.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Histopathology of Red Tattoo Reactions

Bent¹,

Oyen²,

Rustemeyer³

et al. 2020

The American Journal of Dermatopathology

Self Cite

View full text Add to dashboard Cite

Background: Despite popularity of tattoos, complications may occur. In particular, red tattoo reactions due to allergic reactions are the most frequent chronic tattoo reactions. However, little is known about its histopathology and underlying pathomechanisms.Objective: The aim of this article is to analyze the histopathology of red tattoo reactions for diagnostic purposes and to acquire more insight into pathogenesis.Methods: A retrospective cross-sectional study was conducted by reviewing the histopathology of 74 skin biopsies of patients with allergic red tattoo reactions. Histopathological findings, such as inflammation patterns, inflammatory cells and pigment depth and color, were semi-quantified with an in-house validated scoring system by 2 independent senior investigators.Results: Histiocytes and lymphocytes were both present in .93%.Histiocytes were the predominant inflammatory cells in 74.3%, but well-defined granulomas were mostly absent (78.0%). Eosinophils were uncommon (8.1%) The predominantly histiocytic reaction combined with interface dermatitis was the main inflammation pattern (37.9%). Most biopsies showed more than one reaction pattern. Interface involvement was observed in 64.8%, despite the intended depth of standard tattoo procedures, in which pigment is placed deeper, in the upper-and mid-dermis. Statistical analyses showed a significant association between inflammation severity and pigment depth (P = 0.024). In 6 cases (8.1%) pigments could not be retrieved histologically. Conclusions:In this cohort we demonstrated that cutaneous reactions to red tattoo ink are frequently characterized by the combination of dermal predominantly histiocytic infiltrates and epidermal interface dermatitis. Allergic reactions to red tattoo pigments probably represent a combination of a subtype IVa and IVc allergic reaction. Clinicians should be aware of the specific histopathology of these reactions and therefore the importance of taking a diagnostic skin biopsy.

show abstract

Section: Strengths and Limitationsmentioning

confidence: 99%

Histopathology of Red Tattoo Reactions

Bent¹,

Oyen²,

Rustemeyer³

et al. 2020

The American Journal of Dermatopathology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Histopathology is mainly granulomatous inflammation, as shown in our study. These reactions are known to be a possible manifestation of sarcoidosis, tattoo‐associated uveitis, or non‐sarcoidosis 20,21 . Purely based on the cutaneous clinical and histological aspects, differentiation cannot always be made.…”

Section: Discussionmentioning

confidence: 99%

Complications of tattoos and permanent makeup: overview and analysis of 308 cases

Bent

Rauwerdink

Oyen

et al. 2021

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background: Worldwide 10-20% of the population is tattooed. However, tattoo complications can occur, such as allergic tattoo reactions, infections, and manifestations of autoimmune dermatoses. Despite the growing popularity of tattoos and changes in tattoo ink composition over the last decades, little is known about these complications, its clinical aspects, pathomechanism, and relative occurrence.Objective: The aim of this article is to describe the types and clinical aspects of dermatological tattoo complications, its relative occurrence and underlying conditions. Methods:We performed a retrospective cohort study enrolling all patients with tattoo complications from the Tattoo Clinic. Tattoo complications were categorized into infections, inflammatory tattoo reactions, neoplasms, or miscellaneous reactions and correlated to clinical data.Results: Of the total of 326 patients, 301 patients were included with 308 complications. The majority of the complications were chronic: 91.9%. Allergic red tattoo reactions and chronic inflammatory black tattoo reactions (CIBTR) accounted for 50.2% and 18.2%, respectively, of all tattoo complications. Of these CIBTR reactions, extracutaneous involvement was found in 21.4%, including tattoo-associated uveitis (7.1%) and systemic sarcoidosis (14.2%). Of all black tattoo reactions, systemic sarcoidosis was found in 7.8%. Conclusion:Tattoos can cause a wide range in complications that may start years after getting the tattoo. The most frequent tattoo reactions are allergic red tattoo reactions and chronic inflammatory black tattoo reactions, making these the most relevant for the dermatologist. CIBTR have a high percentage of multi-organ involvement, and therefore, screening for sarcoidosis, including ocular involvement, is advised.

show abstract

“…Es zeigten sich bei histopathologischen Untersuchungen eine Persistenz des eingebrachten Pigments als freie Granula in der Epidermis und Dermis, die meisten in Makrophagen in der Dermis und im Bereich der Lidränder an der Oberfläche des Orbicularis-Muskels. Als Nebenwirkungen können neben traumatischen Verletzungen während der kosmetischen Behandlung (dabei liegen auch Fallstudien vor, die eine akzidentielle Verletzung der Hornhaut demonstrieren) Allergien, Dislokation des Pigments sowohl oberflächlich als auch in tiefere Schichten, Entzündungen, Nekrosen und Granulome entstehen [17][18][19][20][21][22][23][24][25].…”

Section: Original Articleunclassified

Einfluss von Permanent Make-up auf die Meibomdrüsen und den Tränenfilm

Laufenböck¹

2020

Spektrum Augenheilkd.

View full text Add to dashboard Cite

Zusammenfassung Hintergrund Ziel dieser Studie war es, Veränderungen hinsichtlich der Meibomdrüsen, der Augenoberfläche und des Tränenfilms durch Lidrandtätowierungen zu ermitteln. Methodik Querschnittsstudie: 100 Augen mit Permanent-Make-up von 50 Patientinnen wurden 100 Augen ohne Permanent-Make-up von 50 Patientinnen gegenübergestellt. Die subjektive Symptomabfrage erfolgte mittels OSDI-Fragebogen und wurde mit den objektiven Testergebnissen – erhoben durch die klinische Untersuchung an der Spaltlampe sowie am Keratographen 5M (Oculus, Germany) – verglichen. Resultate Es zeigte sich ein statistisch signifikanter Unterschied zwischen den beiden Gruppen hinsichtlich des OSD-Index, der NIK-BUT, der Meibomdrüsen und der LIPKO-Falten. Keinen Unterschied zeigte sich in der bulbären Injektion und der Tränenmeniskushöhe. Schlussfolgerungen In der durchgeführten Studie zeigte sich, dass Permanent-Make-up an den Lidrändern zu anatomischen und funktionellen Veränderungen der Meibomdrüsen und des Tränenfilms führt. Diese Ergebnisse korrelieren auch stark mit einem subjektiven okulären Dyskomfort der Patientinnen.

show abstract

Granulomatous tattoo reactions in permanent makeup of the eyebrows

Cited by 25 publications

References 8 publications

Histopathology of Red Tattoo Reactions

Histopathology of Red Tattoo Reactions

Complications of tattoos and permanent makeup: overview and analysis of 308 cases

Einfluss von Permanent Make-up auf die Meibomdrüsen und den Tränenfilm

Contact Info

Product

Resources

About