Granulomatous spinal infections: MR imaging.

Sharif, Hassan; Clark, David; Aabed, M Y; Haddad, Maurice C.; Deeb, S. M. Al; Yaqub, Basim A.; Moutaery, Khalaf R. Al

doi:10.1148/radiology.177.1.2399306

Cited by 162 publications

(90 citation statements)

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“…But it has limited value as it can persist in successfully treated cases [25], as occurred in 15 % (n = 3) of our patients. The resolution of process by means of MR imaging takes approximately 12 weeks [7,8]. From 9 to 12 months after the treatment begins, the image shows increasing signal intensity on T1-weighted images where previous abnormalities were observed on T2 sequences as occurred in 50 % (n = 10) of our series (Figs.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 53%

“…5, 9). Therefore, T2 images revert to normal [7]. This can be due the stimulation of the fat conversion in the yellow bone marrow [12].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 97%

“…Therefore, it is especially helpful in detecting the subclinical ''spinal cord compression syndrome'', in which the neuronal damage can be clearly seen [2]. Surgical election, choosing between anterior and posterior decompression, must be established on the basis of MRI [7]. New technological advances and compatible surgical materials now permit the performance of guided interventional proceedings [29].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…Musculoskeletal involvement of TB is estimated in 1-13 % of patients and spine is affected in more than 50 % of cases [2][3][4][5][6][7][8][9]. It is most prevalent in adults with no sex predominance [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…The sources of spinal infection can be hematogenous spread through arterial vessels, postoperative infection, direct puncture or trauma and also spread from a contiguous focus [1,7,22]. Spinal spread is thought to be hematogenous in most instances [5,22].…”

Section: Introductionmentioning

confidence: 99%

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Imaging findings of Pott’s disease

Rivas-Garcia¹,

et al. 2012

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Tuberculosis (TB) continues to be an important public health problem in developed countries especially in deprived socioeconomic groups, older people, immunocompromised patients, drug-therapy resistant cases and the immigrant population. The spine is the most frequent location of musculoskeletal TB. The wide range of clinical presentations results in difficulties and delays in diagnosis. Advanced disease mimics other infections and malignancy. The diagnosis of spinal infections relies on three main factors: clinical symptoms, imaging and bacteriological culture. Advanced imaging such as Magnetic Resonance Imaging (MRI), Multidetector Computed Tomography (MDCT) and Fluor18-Deoxiglucose Positron Emission Tomography combined with CT (F-18 FDG PET-CT) demonstrate lesion extent, serve as guide for biopsy with aspiration for culture, assist surgery planning and contribute to follow-up. Diagnosis of TB cannot be established solely on the basis of clinical tests or imaging findings and biopsy may be required. Differential diagnosis between tuberculous and pyogenic spondylitis is of clinical importance, but may be difficult on the basis of radiological findings alone. Findings not pathognomonic but favoring tuberculous etiology include: slow progression of lesions with late preservation of disk space, involvement of several contiguous segments, large intraosseous and paraspinal abscesses containing calcifications, and body collapse with kyphotic deformity. In this essay the highlights of TB imaging are reviewed through published literature. In addition, we review retrospectively the radiological findings of 48 patients with tuberculous spondylitis treated from 1993 to 2010. There were 23 male and 25 female patients with a mean age of 53 years.

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Section: Magnetic Resonance Imagingmentioning

confidence: 53%

“…5, 9). Therefore, T2 images revert to normal [7]. This can be due the stimulation of the fat conversion in the yellow bone marrow [12].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 97%

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Imaging findings of Pott’s disease

Rivas-Garcia¹,

et al. 2012

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Spinal Inflammation

Jinkins

Stark

2001

CP Magnetic Resonance Imaging

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Regional myocardial blood volume and flow: First‐pass MR imaging with polylysine‐Gd‐DTPA

Wilke

Kroll

Merkle

et al. 1995

Magnetic Resonance Imaging

131

104

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The authors investigated the utility of an intravascular magnetic resonance (MR) contrast agent, poly-L-lysine-gadolinium diethylenetriaminepentaacetic acid (DTPA), for differentiating acutely ischemic from normally perfused myocardium with first-pass MR imaging. Hypoperfused regions, identified with microspheres, on the first-pass images displayed significantly decreased signal intensities compared with normally perfused myocardium (P < .0007). Estimates of regional myocardial blood content, obtained by measuring the ratio of areas under the signal intensityversus-time curves in tissue regions and the left ventricular chamber, averaged 0.12 mL/g ± 0.04 (n = 35), compared with a value of 0.11 mL/g ± 0.05 measured with radiolabeled albumin in the same tissue regions. To obtain MR estimates of regional myocardial blood flow, in situ calibration curves were used to transform first-pass intensity-time curves into content-time curves for analysis with a multiple-pathway, axially distributed model. Flow estimates, obtained by automated parameter optimization, averaged 1.2 mL/min/g ± 0.5 [n = 29), compared with 1.3 mL/min/g ± 0.3 obtained with tracer microspheres in the same tissue specimens at the same time. The results represent a combination of T1-weighted first-pass imaging, intravascular relaxation agents, and a spatially distributed perfusion model to obtain absolute regional myocardial blood flow and volume. Index termsContrast agent, blood pool; Contrast enhancement; Coronary vessels, diseases, 54.76; Heart, flow dynamics; Heart, MR, 51.12143; Model, mathematical; Myocardium, blood supply, 511.12143; Myocardium, MR, 511.12143 NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptA growing body of evidence supports the feasibility of evaluating myocardial perfusion with magnetic resonance (MR) imaging with contrast agents. A variety of intravascular and extracellular MR contrast agents have been studied for delineation of infarcted myocardium (1-3) and for identification of acutely ischemic and reperfused cardiac muscle (4,5). The first-pass MR imaging technique with the extracellular contrast agent gadolinium diethylenetriaminepentaacetic acid (DTPA) has been used to assess myocardial perfusion in patients at rest (6,7) and during pharmacologic stress (8,9). Although experimental (10) and patient studies have demonstrated the suitability of extracellular contrast agents for detecting hypoperfused myocardium, such agents are inherently disadvantageous for flow quantification because they are not confined to a single volume compartment within the tissue. Consequently, first-pass kinetics of an extracellular agent are determined not only by blood flow but by the intravascular and interstitial distribution volumes and by permeability across the capillary wall. This exchange between the vascular and interstitial compartments greatly complicates quantification of tissue blood flow unless it is either very fast or slow compared with flow rates (11).The objective of the present study was to...

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Granulomatous spinal infections: MR imaging.

Cited by 162 publications

References 0 publications

Imaging findings of Pott’s disease

Imaging findings of Pott’s disease

Spinal Inflammation

Regional myocardial blood volume and flow: First‐pass MR imaging with polylysine‐Gd‐DTPA

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