Granulomatous skin infection caused by Scopulariopsis brevicaulis

Bruynzeel, Ineke; Starink, Th. M.

doi:10.1016/s0190-9622(98)70392-5

Cited by 22 publications

(8 citation statements)

References 17 publications

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“…Among the genus Scopulariopsis , which are saprophytes found in soil worldwide, S. brevicaulis , S. brumptii , S. acremonium , S. fusca , and S. koningii are frequently related to human infections4,8. Most human infection caused by S. brevicaulis is onychomycosis, although there are several reports of other infections including skin infection, endocarditis, and endophthalmitis in patients with impaired immunity, trauma or surgery2,9,10. S. brevicaulis onychomycosis represents 1~10% of the nondermatophytic onychomycosis cases depending on the population, geographic regions, and the reporters3-5.…”

Section: Discussionmentioning

confidence: 99%

“…and Acremonium spp., which have been often considered as saprophytic or opportunistic fungi1. Since several cases of nondermatophytic onychomycosis have been reported, even in healthy subjects, recent increase in diseases with immune suppressed individuals as well as prominent environmental changes have brought these non-dermatophytic fungi into focus2,3. S. brevicaulis represents 1~10% of the non-dermatophytic onychomycoses3-5.…”

Section: Introductionmentioning

confidence: 99%

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Onychomycosis Caused byScopulariopsis brevicaulis: Report of Two Cases

et al. 2012

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Onychomycosis is usually caused by dermatophytes, but some nondermatophytic molds and yeasts are also associated with invasion of nails. Scopulariopsis brevicaulis is a nondermatophytic mold found in soil as a saprophyte. We report two cases of onychomycosis caused by S. brevicaulis in a 48-year-old male and a 79-year-old female. The two patients presented with a typical distal and lateral subungual onychomycosis. Direct microscopic examination of the potassium hydroxide preparation revealed fungal elements. From toenail lesions of the patients, brown colonies with powdery surface, which are a characteristic of S. brevicaulis, were cultured on two Sabouraud's dextrose agar plates. Three cultures taken from nail plates within a 2-week interval yielded similar findings. Numerous branched conidiophores with chains of rough walled, lemon-shaped conidia were observed in slide culture by light microscopy and scanning electron microscopy. The nucleotide sequences of the internal transcribed spacer for the two clinical isolates were identical to that of S. brevicaulis strain WM 04.498. To date, a total of 13 cases of S. brevicaulis onychomycosis including the two present cases have been reported in Korea. Mean age of the patients was 46.1 years, with a higher prevalence in males (69.2%). Toenail involvement was observed in all cases including a case involving both fingernail and toenail. The most frequent clinical presentation was distal and lateral subungual onychomycosis in 12 cases, while one case was proximal subungual onychomycosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Onychomycosis Caused byScopulariopsis brevicaulis: Report of Two Cases

et al. 2012

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“…The spectrum of severe human mycoses includes the formation of fungus balls in preformed pulmonary cavities (1), keratitJs (2), post-traumatic endophthalmitis (3), disseminated skin lesions in patients with AIDS (4), granulomatous subcutaneous infections (5). invasive hyalohyphomycosis (6), pneumonia in leukaemic patients (7), endocarditis related to valvuloplasty or prosthetic valves (8), and even fatal disseminated infection following bone marrow transplantation (9).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Granulomatous Infection Caused by Scopulariopsis brevicaulis

Wu¹,

Lee²,

Lin³

et al. 2009

Acta Derm Venerol

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“…Rare reports have documented S. brevicaulis infection in skin sites other than nails. [13][14][15][16] While in all cases, S. brevicaulis was confirmed by culture, in none is there a histomorphologic description of the mould.…”

Section: Scopulariopsis Brevicaulis and Dermatophyte Histopathologymentioning

confidence: 94%

Histopathologic evidence of the nondermatophytic mould Scopulariopsis brevicaulis masking the presence of dermatophytes in a toenail infection

Stefanato

Verdolini

2009

J Cutan Pathol

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Nondermatophytic toenail infection with Scopulariopsis brevicaulis is rare, but may occur often in association with dermatophytes. We report a case of an 84-year-old man who presented with onychomycosis of the big toenail. Histopathologic examination of the avulsed nail showed evidence of S. brevicaulis coinfection with a dermatophyte, despite negative mycology results for the latter. Our case underscores the importance of histopathologic examination of nail specimens as an additional invaluable tool in the diagnosis of onychomycosis, as it may unmask false-negative mycology findings.

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Granulomatous skin infection caused by Scopulariopsis brevicaulis

Cited by 22 publications

References 17 publications

Onychomycosis Caused byScopulariopsis brevicaulis: Report of Two Cases

Onychomycosis Caused byScopulariopsis brevicaulis: Report of Two Cases

Cutaneous Granulomatous Infection Caused by Scopulariopsis brevicaulis

Histopathologic evidence of the nondermatophytic mould Scopulariopsis brevicaulis masking the presence of dermatophytes in a toenail infection

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