Granulomatous mycosis fungoides, a rare subtype of cutaneous T-cell lymphoma

Kogut, Marta; Hadaschik, Eva; Grabbe, Stephan; Andrulis, Mindaugas; Enk, Alexander H.; Hartschuh, Wolfgang

doi:10.1016/j.jdcr.2015.05.010

Cited by 9 publications

(10 citation statements)

References 7 publications

(15 reference statements)

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“…The diagnosis of lupus vulgaris is often challenging due to varied clinical presentations. Lupus vulgaris has been reported to be misdiagnosed as mycosis fungoides, 4 leishmaniasis, 5 cutaneous malignancy, 6 hemangioma 7 etc. The patient was initially misdiagnosed with sarcoidosis, which, and leprosy, are exactly two chief diseases in diagnostic difficulty to distinguish.…”

Section: Discussionmentioning

confidence: 99%

Giant Lupus Vulgaris with Negative T-SPOT.TB, a Case Report and Literature Review

Wang¹,

Wang²

2022

CCID

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Lupus vulgaris is a paucibacillary form of cutaneous tuberculosis (CTB) which is accounting for 1–2% of all tuberculosis cases. Here, we report a rare huge lupus vulgaris misdiagnosed as sarcoidosis for 11 years. A 65-year-old man presented to dermatology outpatient with a large asymptomatic erythematous plaque and erosions on his neck. Sarcoidosis was initially diagnosed on the basis of negative interferon-gamma release tests and biopsies of lymph nodes and lesions. The patient was treated with long-term oral steroid and immunosuppressive agents, but the lesions expanded gradually. Lupus vulgaris was finally diagnosed by combining molecular detection and mycobacterial culture. The skin lesions were resolved after six months of standard antituberculosis therapy. We report this case to analyze the reasons for the misdiagnosis and review-related literature to further provide experience for the diagnosis and treatment of cutaneous tuberculosis with negative T-SPOT.TB.

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Section: Discussionmentioning

confidence: 99%

Giant Lupus Vulgaris with Negative T-SPOT.TB, a Case Report and Literature Review

Wang¹,

Wang²

2022

CCID

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“…The diagnosis may be supported by immunohistochemistry and T-cell receptor gene rearrangement. Interestingly, a case of granulomatous mycosis fungoides of the auricle resembling a turkey ear that was initially suspected as LV has been described in the literature …”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, a case of granulomatous mycosis fungoides of the auricle resembling a turkey ear that was initially suspected as LV has been described in the literature. 9 Leishmania recidivans develops in the site of previous infection that had healed and may mimic LV both clinically and histopathologically. 10 Definitive diagnosis requires the demonstration of Leishmania-Donovan bodies or positive result of polymerase chain reaction testing.…”

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confidence: 99%

A “Turkey Ear” Persisting for 5 Decades

2021

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A woman in her 50s presented with an edematous, massively enlarged right auricle. The patient had immigrated to Israel 9 years before admission. She was adamant that the lesion had been present since early childhood but had gradually increased with a recent appearance of foul-smelling otorrhea. On examination, the auricle was markedly enlarged, edematous, and encircled by an erythematous, indurated plaque partially covered with a fine scale (Figure 1A). Diascopy revealed an "apple jelly" appearance. There was no local or distant lymphadenopathy; general physical examination findings were unremarkable.Results of routine laboratory investigations, including complete blood cell count, biochemical profile, liver function tests, and chest radiography, were normal. An intradermal Mantoux test induced a 20-mm induration. Histopathologic evaluation of the cutaneous lesion revealed noncaseating granulomatous dermatitis involving the dermis (Figure 1B). High magnification demonstrated tuberculoid dermal granulomas composed of histiocytes and Langhans giant cells surrounded by lymphoplasmacytic infiltrate (Figure 1C). Results of polarized light examination and periodic acid-Schiff, Ziehl-Neelsen, Giemsa, Gram, and Grocott methenamine silver stains were negative for microorganisms.

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“…Cutaneous granulomatous lesions in patients with malignant lymphomas have been reported; however, no previous reports have described cutaneous lesions of mucosa-associated lymphoid tissue (MALT) lymphoma with a granulomatous reaction. [1][2][3][4] A 61-year-old woman presented with reddish-brown plaques on her trunk (Fig. 1a).…”

Section: Cutaneous Granulomatous Lesions In a Patient With Mucosa-assmentioning

confidence: 99%

“…1 It may present with non-scaly, thick plaques or nodules and can mimic benign disease such as granuloma annulare or granulomatous rosacea. 2 Granulomatous mycosis fungoides has more frequent disease progression and poorer response to skindirected therapy when compared with classic mycosis fungoides. 3 Despite this, overall survival does not appear to differ.…”

mentioning

confidence: 99%