Granulomatous mastitis: A retrospective review of 49 patients

Gırgın, Sadullah; Uslukaya, Ömer; Yılmaz, Edip Erdal; Fırat, Uğur; Gümüş, Hatice; Kapan, Murat; Gümüş, Metehan

doi:10.5798/diclemedj.0921.2015.01.0524

Cited by 6 publications

(7 citation statements)

References 25 publications

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“…On the contrary, Western countries like the USA [15], the UK [5], and New Zeeland [20] have a remarkably lower rate of IGM. Our work, as well as that of others [20,28,29], revealed that IGM is usually seen in women who are lactating or those who have been lactating. This finding may explain why IGM is more common in Middle Eastern countries such as Iran, Turkey, and Egypt than in other regions of the world.…”

Section: Discussionmentioning

confidence: 76%

“…Undoubtedly, these figures do not provide accurate data regarding the exact frequency of IGM in the mentioned countries. The present study shows that the frequency of IGM in Egypt approximates those in Turkey and Iran [21,28]. On the contrary, Western countries like the USA [15], the UK [5], and New Zeeland [20] have a remarkably lower rate of IGM.…”

Section: Discussionmentioning

confidence: 99%

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Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients

Helal

Shash²,

El-Din³

et al. 2016

Acta Cytologica

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Background: The etiology of idiopathic granulomatous mastitis (IGM) is unknown, and it is commonly misdiagnosed clinically and/or radiologically as breast cancer. The role of fine-needle aspiration cytology (FNAC) in its diagnosis is still a matter of debate. The aim of the current study is to assess the value of FNAC in the diagnosis of IGM, and to search for the presence of bacteria in IGM with cystic vacuoles, which was described recently by a few authors. Materials and Methods: Retrospective study of cytologic smears and histologic tissue sections of 65 Egyptian IGM cases was done along with microbiologic testing. A comparison of the frequency of IGM in Egypt to that of other populations was also made. Results: IGM has typical FNA features which can easily exclude malignancy. Histologically, cystic vacuoles were encountered in 35 out of 65 cases (53.9%), with only 6 (17.14%) of these cases showing Gram-positive bacilli (GPB). The frequency of IGM in Egypt is comparable to those in other Middle Eastern countries but much higher than in Western countries. Conclusion: IGM is a common breast disease in Egypt. FNAC in IGM has a high diagnostic accuracy. This study supports the few recent studies that have detected GPB in IGM with cystic vacuoles. Thus, bacteriologic examination in such cases may affect the treatment strategy.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients

Helal

Shash²,

El-Din³

et al. 2016

Acta Cytologica

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“…Although it has been reported in the literature that some patients diagnosed with IGM used OCS, no relation was found between OCS use and IGM 5 . In the study by Shin et al 5 9 . In a study conducted by Özşen et al on 90 patients, it was reported that sarcoidosis was diagnosed in 1 patient 12 .…”

Section: Discussionmentioning

confidence: 97%

The Role of Corynebacterium in The Etiology of Granulomatous Mastitis

YAMAN,

GİRGİN,

AKPOLAT

et al. 2023

J Cukurova Anesth Surg

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Introduction: Granulomatous mastitis (GM) is a rare, benign, chronic inflammatory illness of the breast. It is characterized by necrotizing granulomatous lobulitis of the breast that clinically mimics breast cancer. The aim of this study was to examine the existence of Corynebacterium strains thought to be covered in the etiology of idiopathic granulomatous mastitis. Material and Methods: In this study, we retrospectively analyzed the results of 201 breast tru-cut biopsies carry out for diagnostic purposes in the Department of General Surgery. The tissue samples of 41 patients with histopathologically diagnosed GM were examined by Gram staining. The existence of Corynebacterium kinds was investigated microscopically by adding appropriate medium. Results: The mean age of 41 female patients with GM was 35. 7 years and the age range was 20-58 years. At the end of the study, Corynebacterium amycolatum was defined as the causative microorganism as a consequence of microbiologic examination of the tissue sample of one patient (2.4%). Conclusion: We consider that Corynebacterium is not the etiologic agent of GM. Additionally studies with large case series are needed to explain the etiology.

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“…Moreover, it is difficult to treat idiopathic granulomatous mastitis especially if presented with fistula and abscess formation. 2 The treatments for idiopathic granulomatous mastitis include corticosteroids 2,3 , immunosuppressants 4 , antibiotics, abscess drainage, and surgical excision. 5 Although a preferred therapeutic modality has not been established, corticosteroid therapy is effective for shrinking the granulomatous mass.…”

Section: Introductionmentioning

confidence: 99%

“…5 Although a preferred therapeutic modality has not been established, corticosteroid therapy is effective for shrinking the granulomatous mass. 2,6 Systemic corticosteroid therapy was first proposed by De Hertogh et al 3 , who investigated the efficacy of different treatments and concluded that a corticosteroid is an appropriate option for the treatment of the disease. Furthermore, Sukurai et al 7 sought this pharmacological approach and they authenticated that corticosteroids could be efficient in 87% of patients without any relapse, whereas Maffini et al reported successful outcomes by administering systemic antibiotic therapy and 25 mg/kg/day prednisolone.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Oral Prednisolone in the Management of Idiopathic Granulomatous Mastitis

Tazdina Hoque Khan,

Shahidul Huq,

S M Minhajul Hasan Chowdhury

et al. 2024

Mediscope

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Background: Idiopathic granulomatous mastitis (IGM) is a benign inflammatory lesion of the mammary gland. Globally it possesses a major diagnostic and therapeutic problem. To date, there is no universally agreed treatment for this condition. Many treatment modalities have been attempted from conservative therapy to mastectomy but none of them has shown satisfactory results. Recent studies have shown promising results of corticosteroids on idiopathic granulomatous mastitis, so steroid therapy can be an effective treatment for idiopathic granulomatous mastitis. The goal of the study is to provide a therapeutic strategy in the future for idiopathic granulomatous mastitis. Methods: Our study included all patients with idiopathic granulomatous mastitis confirmed histologically by core needle/incisional biopsy at the general surgery unit of Chittagong Medical College Hospital and the private hospitals in the Chittagong Metropolitan City for a period of one year from October 2016 to September 2017. A total of seventy patients were included in the study provided they fulfilled predetermined criteria. All of them were included in this study by purposive sampling. After diagnosis oral prednisolone (1mg/kg/day) was given and the cases were observed by personal interview and through telephone interview. The patients were on follow-up for 06 months. Age, size of the breast lump, breast pain, nipple discharge, and skin changes were recorded in all cases. Results were analyzed using mean, percentage, and proportion as appropriate. Results: The mean age was 26.35±13.5 years ranging from 19 to 40 years. Out of 70 patients, Core cut biopsy was done in 55 patients (78.58%), and incisional biopsy with abscess drainage was performed in 15 patients (21.42%). 59 patients (84.28%) had complete recovery after a single cycle of steroid treatment, remaining 11 patients (15.72%) had recurrence, among them 6 patients were cured after 2nd cycle of steroids but unfortunately, 5 patients did not respond. Though complications were found in 50 patients, all of them made good progress in the short term. Conclusion: We recommend steroid therapy as the first-line treatment in our study. However, prospective, randomized clinical trials are needed to determine the treatment algorithm. Mediscope 2024;11(1): 22-26

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Granulomatous mastitis: A retrospective review of 49 patients

Cited by 6 publications

References 25 publications

Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients

Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients

The Role of Corynebacterium in The Etiology of Granulomatous Mastitis

Efficacy of Oral Prednisolone in the Management of Idiopathic Granulomatous Mastitis

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