Granulomatous Mastitis: A Lesion Clinically Simulating Carcinoma

Kessler, E; Wolloch, Y

doi:10.1093/ajcp/58.6.642

Cited by 620 publications

(529 citation statements)

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“…Breast mastitis can be lactation and occur during breastfeeding, or nonlactational, which, however, can be an infectious disease, such as tuberculosis, sarcoidosis, cat scratch, Cryptococci and other rare infections or inflammatory diseases like periareolar mastitis, fibrocystic change, or granulomatous mastitis 3,5 . Kessler and Wolloch first reported the IGM in 1972 like a lesion simulating breast carcinoma in five case reports 6 . This is a rare and benign condition, affecting young women, younger than 50 years of age.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic granulomatous mastitis: diagnosis and follow-up with magnetic resonance imaging

Andrade¹,

Heinzen²,

Pincerato³

et al. 2017

Rev. Bras. Mastol. (Impr.)

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A mastite granulomatosa é uma condição rara e benigna da mama que, em alguns casos, possui etiologia desconhecida de doença inflamatória benigna, a mastite idiopática. Seu diagnóstico normalmente é feito por exclusão. Os exames de imagens têm demonstrado achados inespecíficos que podem sugerir uma doença inflamatória, um carcinoma ou não apresentar alterações. Deve ser realizado um diagnóstico diferencial com outras causas de mastites, sempre alertando para o risco de carcinoma inflamatório. Os exames de imagem servem mais para descartar uma malignidade do que para confirmar a mastite granulomatosa idiopática. Em função de tanto os exames de imagem como o exame físico poderem simular uma lesão maligna da mama, o laudo histopatológico é fundamental para estabelecer o diagnóstico. A sua etiologia permanece desconhecida, portanto, o tratamento é controverso na literatura, com alguns autores recomendando cirurgia, outros a imunossupressão e, por fim, alguns antibióticos. É apresentado o caso de uma paciente de 21 anos com uma lesão suspeita na mama associada à descarga papilar. Durante a investigação, houve um realce de 12 x 6 x 8,5 cm na ressonância magnética associado a sinais inflamatórios na pele e nos linfonodos. O exame anatomopatológico evidenciou um quadro de mastite granulomatosa idiopática. O realce desapareceu completamente após o tratamento conservador com corticoterapia. A mamografia e o ultrassom também podem demonstrar alterações inespecíficas, tais como assimetria focal, massa indefinida ou distorção. Apesar das limitações dos exames de imagem, demonstrou-se, neste relato, que a ressonância magnética pode ser utilizada para monitorar a resposta clínica ao tratamento conservador e o acompanhamento pelo risco de recorrência. PALAVRAS-CHAVE:Diagnóstico por imagem; mastite; mastite granulomatosa. RESUMO ABSTRACTGranulomatous mastitis is a rare and benign condition of the breast that, in some cases, has an unknown etiology of benign inflammatory disease know as idiopathic mastitis. Your diagnosis is usually made by exclusion. Imaging tests have shown nonspecific findings that may suggest an inflammatory disease, a carcinoma, or no changes. A differential diagnosis should be made with other causes of mastitis, always alerting to the risk of inflammatory carcinoma. Imaging tests are more useful to rule out malignancy than to confirm idiopathic granulomatous mastitis. Because both imaging and physical examination can mimic a malignant lesion of the breast, the histopathological report is fundamental to establish the diagnosis. Its etiology remains unknown, so the treatment is controversial in the literature, with some authors recommending surgery, others immunosuppression, and, finally, some antibiotics. We report the case of a 21-year-old woman with a suspected lesion in the breast associated with papillary discharge. During the investigation, there was a 12 x 6 x 8.5 cm enhancement on magnetic resonance imaging associated with inflammatory signs on the skin and lymph nodes. Anatomopathological examination ...

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Section: Discussionmentioning

confidence: 99%

Idiopathic granulomatous mastitis: diagnosis and follow-up with magnetic resonance imaging

Andrade¹,

Heinzen²,

Pincerato³

et al. 2017

Rev. Bras. Mastol. (Impr.)

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“…Idiopathic Granulomatous Mastitis (IGM) is a rare, chronic, non-malignant and non-life-threatening breast disease (1). Clinically and radiologically, it mimics carcinoma of the breast.…”

Section: Introductionmentioning

confidence: 99%

Granulomatous Mastitis Concurrence with Breast Cancer

Çalış

Kilitçi

2018

Eur J Breast Health

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“…It is a rare, nonneoplastic chronic inflammatory disease of the breast [1]. This selflimiting, non-case eating benign disorder also known as Idiopathic Granulomatous Lobular Mastitis, a breast disease of unknown etiology that was first described by Kessler and Wolloch in 1972 [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Due to this masquerade as Breast carcinoma and its resemblance to infection; primarily exclusion of infectious causes of breast disease and malignancy is mandatory [2,[11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Non-surgical Management in Idiopathic Granulomatous Mastitis

Akbari¹,

Lotfolahzadeh²,

Nafissi³

et al. 2014

J Women's Health Care

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Introduction: Idiopathic Granulomatous Mastitis; Despite its low incidence, is in high interest due to masquerading as carcinoma of the breast. In confirmed IGM case series, it`s been reported that more than 50% of patients were initially misdiagnosed as affecting by carcinoma of the Breast. Herein we are introducing a non-surgical management of IGM with frequently aspiration of the masses accompanied by using bacteriostatics and close regular surveillance.

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Granulomatous Mastitis: A Lesion Clinically Simulating Carcinoma

Cited by 620 publications

References 0 publications

Idiopathic granulomatous mastitis: diagnosis and follow-up with magnetic resonance imaging

Idiopathic granulomatous mastitis: diagnosis and follow-up with magnetic resonance imaging

Granulomatous Mastitis Concurrence with Breast Cancer

Non-surgical Management in Idiopathic Granulomatous Mastitis

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