Granulomatous lung diseases

Самсонова, М. В.; Черняев, А. Л.

doi:10.18093/0869-0189-2017-27-2-250-261

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…В настоящее время во всем мире признана эффективность применения компьютерной томографии высокого разрешения (КТВР) в изучении патологии органов дыхания, так как оценка структурных изменений легких и их локализация тесно связаны между собой. Сопоставление выявленных рентгенологических изменений с результатами морфологического исследования позволяет устранить многие вопросы, возникающие при установлении заболевания органов дыхания [10,11].…”

Section: Index Terms: Computed Tomography; Non-tuberculous Mycobacterunclassified

X-Ray Morphological Semiotics of Non-Tuberculous Mycobacterial Pulmonary Disease

Амансахедов¹,

Лепеха²,

Dmitrieva³

et al. 2018

Vestn. rentgenol. radiol.

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Objective: to evaluate the X-ray radiological features of nontuberculous mycobacterial pulmonary disease (NTMPD) versus morphological findings.Material and methods. The investigation enrolled 37 patients, in whom the radiographic signs of dissemination were determined and various types of NTMPD were identified. The investigation was conducted on a Siemens Somatom Emotion 16 multislice computed tomography (MSCT) scanner using a high-resolution algorithm (Quick Time Virtual Reality). To clarify the activity of pathological changes in the thoracic organs, 16 (43.2%) patients underwent a radionuclide study with 99mTc-technetrile on a Nucline Spirit gamma camera in planar and single photon emission computed tomography modes.The diagnosis was verified by sputum smear microscopy and clinical laboratory and bronchologic examinations: bronchoalveolar lavage in 11 (29.7%) patients, various types of bronchial biopsies in 17 (46.0%), morphological examinations, and videoassisted thoracoscopic surgery for pulmonary resection in 9 (24.3%).Results. The dissemination foci in mycobacterial diseases were characterized by their location in the lung parenchyma with vascular and bronchial involvement and reactive changes in the pulmonary pleurae and intrathoracic lymph nodes (ITLN). In 92.7% of cases, the detected foci were predominantly centrilobular with endobronchial localization. Their contours were mixed with clear and fuzzy outlines in 98.7% of cases. In 70.3% of cases, the foci were asymmetrically localized mainly in the subpleural areas of the lung and 12.3% of cases were accompanied by reactive involvement of the visceral pleura.CT study revealed a tree-in-bud sign in 96.7% of cases, frosted glass in 10.2%, and mosaic perfusion in 13.2%. A more than 10-mm increase in ITLN was found in 11.7% of cases.In a number of cases, it was difficult to speak about the activity of the pathological process in the lung and ITLN, as shown by MSCT. In this case, a lung radionuclide study with 99mTc-technetrile was carried out in the planar mode. The degree of tracer accumulation, localization, and extent were analyzed in the planar mode.Conclusion. Thus, the CT typical signs of NTMPD are the asymmetric location of its foci with an endobronchial extension, peribronchovascular localization of foci; the presence of a CT tree-in-bud sign; and the slight involvement of the pulmonary pleurae in the process. 99mTs-technetril radionuclide study has established that the most active inflammatory process is located in the lung and the tracer accumulates in the pathologically altered lymph nodes.

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Section: Index Terms: Computed Tomography; Non-tuberculous Mycobacterunclassified

X-Ray Morphological Semiotics of Non-Tuberculous Mycobacterial Pulmonary Disease

Амансахедов¹,

Лепеха²,

Dmitrieva³

et al. 2018

Vestn. rentgenol. radiol.

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“…Статистически значимой разницы между результатами уровня анти-MVC и анти-CCP в группе сравнения с контрольной группой обнаружено не было (р = 0,18). При туберкулезе у пациентов нередко наблюдаются различные клинические симптомы, характерные для системных заболеваний [11]. К наиболее ярким примерам можно отнести ревматоид Понсе, реактивный неспецифический артрит, возникающий на фоне туберкулезной инфекции, при котором M. tuberculosis не выявляется непосредственно в ткани суставов.…”

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Characteristics of Autoimmune Inflammation in the Patients With Lung Tuberculosis

et al. 2019

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Tuberculosis is a granulomatous disease caused by Mycobacterium tuberculosis, being characterized by the development of caseous granulomas in various organs, mainly in lungs. M. tuberculosis is known to be a trigger for autoimmune inflammation, due to the possible mimicry of bacterial proteins as autoantigens. Recently, a significance of mesenchymal vimentin as an autoantigen in mycobacterial infections has been actively discussed. The aim of the present study was to determine autoantibodies for various vimentin modifications in the patients with tuberculosis.The study was performed in 2014-2017 and included 28 patients with pulmonary tuberculosis (group I), 30 patients with nonspecific lung diseases (group II): 15 with granulomatous polyangiitis, and 15 with different alveolites. Control group consisted of healthy subjects (n = 40). Concentration of antibodies to mutated citrullinated vimentin (anti-MCV) was measured using ELISA (ORGENTEC, Germany). The patients with elevated anti-MCV levels were tested for antibodies to cyclic citrullinated peptide (anti-CCP) using ELISA technique (EUROIMMUN, Germany). Statistical analysis was carried out using GraphPad Prism 6 (GraphPad Software, USA), Statistica 10 (Statsoft, USA) using nonparametric analysis of samples with Mann-Whitney and Chi-square criteria, and Spearman method for correlation analysis. The differences were considered statistically significant at p < 0.05.The anti-MCV concentrations were significantly higher in patients with tuberculosis (group I, 60.7% of cases, 17/28) than in group II, and control group (23.6 and 25.0% of cases, respectively). No statistically significant differences were revealed between the results of anti-MVC and anti-CCP levels in comparison group with the control group (p = 0.18).High levels of anti-MCV antibodies in the patients with pulmonary tuberculosis reflect an opportunity of developing autoimmune process in the disease pathogenesis. Measurement of plasma anti-MCV antibody concentrations may be important for correction of the therapy, especially upon administration of immunosuppressive and hormonal corticosteroid drugs. It has been shown that anti-CCP are not characteristic to the lung diseases.

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Atypical histologic presentation of Pneumocystis pneumonia as granulomatous lung nodules

Pyden

VanderLaan

Alonso

et al. 2021

Human Pathology: Case Reports

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Granulomatous lung diseases

Cited by 6 publications

References 17 publications

X-Ray Morphological Semiotics of Non-Tuberculous Mycobacterial Pulmonary Disease

X-Ray Morphological Semiotics of Non-Tuberculous Mycobacterial Pulmonary Disease

Characteristics of Autoimmune Inflammation in the Patients With Lung Tuberculosis

Atypical histologic presentation of Pneumocystis pneumonia as granulomatous lung nodules

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