Granulomatous Lobular Mastitis: A Complex Diagnostic and Therapeutic Problem

Akçan, Alper; Akyıldız, Hızır; Deneme, Mehmet Ali; Akgün, Hülya; Arıtaş, Yücel

doi:10.1007/s00268-005-0476-0

Cited by 156 publications

(247 citation statements)

References 37 publications

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“…Granulomatous inflammation of the breast is an inflammatory process with multiple etiologies (Table 1). It can be caused by breast cancer, tuberculosis, granulomatous mastitis (GM), sarcoidosis, fungal infections such as actinomycosis, parasites such as filariasis, Wegener's granulomatosis, duct ectasia, brucellosis, and traumatic fat necrosis [42,43].…”

Section: Tissue Diagnosismentioning

confidence: 99%

Breast Tuberculosis

2015

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Section: Tissue Diagnosismentioning

confidence: 99%

Breast Tuberculosis

2015

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“…Several other reports of using 60 mg/kg/day prednisolone to treat IGM have also been published. However, in the literature the recommended dose ranges between 0.5 and 2 mg/kg/day (11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

The effect of corticosteroid treatment on bilateral idiopathic granulomatous mastitis

2017

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Idiopathic granulomatous mastitis (IGM) is the commonly encountered form of granulomatous mastitis that may result into repetitive infections and/or abscess formation. Mastitis may develop secondary to a systemic disorder such as tuberculosis, diabetes mellitus, or rheumatoid arthritis, or it may develop as an idiopathic disorder. Idiopathic granulomatous mastitis is the most frequent form of all granulomatous diseases affecting the breast. This disorder frequently presents as painful and fast-growing mass in the breast. Biopsy is required to confirm diagnosis. Surgical excision and immunosuppressive treatment with corticosteroids are employed for therapeutic management. Here we present 3 female cases of bilateral IGM who were followed up and treated successfully with 1 mg/kg/day prednisolone.

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“…In the relapsed cases supplementary therapeutic treatment is advised. Taghizadeh et al (2007) and Akcan et al (2006) other appropriate choices are as following: oral steroid therapy with a dose of 16 mg daily for 6 weeks and gradual tapering and surgical approach in the relapsed cases (Azlina et al, 2003;Hirata et al, 2003) waiting and conservative approach with short interval follow-up periods (Lai et al, 2005;Diesing et al, 2004) and finally using Metothrexate and Colchicine in cases resistant to corticotherapy. Diesing et al (2004) and Kim et al (2003) it is essential to ruled out infectious causes in corticotherapy cases and antibiotic treatment should start before administration of oral steroid in abscess cases.…”

Section: Resultsmentioning

confidence: 99%

Idiopathic Granulomatous Mastitis: A Case Report

Varshochi¹

2010

American Journal of Infectious Diseases

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Problem statement: Granulomatous Lobular Mastitis (GLM) or autoimmune mastitis is a rare and benign disease which, except one case reported in an old man, is usually seen during pregnancy or lactation period. This disease was described for the first time by Kessler. Approach: Our case is a 34 year-old woman who has a child with a history of using OCP that primary complaint was swelling, heat and erythema in the right breast. She was diagnosed with mastitis and treated with antibiotics for one month, later on she had experienced stiffness in the breast and a mass was also palpable. The patient was performed surgical drainage and treated with wide spectrum antibiotics being diagnosed with abscess. After one month, a solid mass was palpable so, mammography was performed and the mass was surgically resected with a suspicion of tumor. Results: The pathology report revealed granulomatous mastitis with non caseified granuloma. For Anti-TB treatment was started as medication regime and after 40 days fistula with frequent secretions appeared. Antituberculosis medications stopped and other conditions resulting in none caseified granuloma. In microscopic view granulomatous mastitis along with abscess was reported. Corticosteroids were started and the mass became smaller gradually, the fistula also closed and secretions dried out. Conclusion: Granulomatous Lobular Mastitis is a benign inflammatory breast disease. Cause of disease is still unknown, but some factors have been suggested such as local autoimmune, reaction to the delivery, previous use of contraceptives and infectious causes. The best treatment proposed is corticosteroid therapy in which the mass dwindle and the fistula is closed and secretions dried. The case is now under treatment with corticosteroids and all her symptoms have improved.

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Granulomatous Lobular Mastitis: A Complex Diagnostic and Therapeutic Problem

Cited by 156 publications

References 37 publications

Breast Tuberculosis

Breast Tuberculosis

The effect of corticosteroid treatment on bilateral idiopathic granulomatous mastitis

Idiopathic Granulomatous Mastitis: A Case Report

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