Granulomatous Hepatitis

Guckian, James C.

doi:10.7326/0003-4819-65-5-1081

Cited by 126 publications

(11 citation statements)

References 56 publications

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“…After this, adult worms can cause obstruction of the biliary tracts, with thickening, dilatation, and fibrosis of the segmental bile ducts. 3 The degree of hepatic destruction is consistent with the number of flukes. The overall time of vitality of mature F. hepatica worms in the liver is 10 years.…”

Section: Discussionmentioning

confidence: 49%

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Granulomatous hepatitis triggered by liver Fasciola infestation: A case report

Ghavidel¹

2016

J Anal Res Clin Med

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Section: Discussionmentioning

confidence: 49%

“…Diagnosis was eosinophil rich necrotizing granuloma (Figure 3). [6][7][8] Hepatic granulomatosis is seen with a large number of diseases, 3 their prevalence depends upon topography and geographical status. It may be an accidental finding on otherwise normal liver biopsy specimen.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous hepatitis triggered by liver Fasciola infestation: A case report

Ghavidel¹

2016

J Anal Res Clin Med

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“…Serum levels of liver enzymes such as aspartate aminotransferase and alanine aminotransferase were raised in 80% in tubercular group; others have reported elevated levels in 70% [4]. Abnormalities in these enzyme levels in hepatic TB patients were present in 91–94% of jaundiced group and in only 5% of the nonjaundiced patients [18]. Other parameters like serum albumin, serum globulin, albumin/globulin ratio, and gamma-glutamyl transpeptidase were considered in some of the studies [4, 5, 15] but are nonspecific for hepatic TB.…”

Section: Discussionmentioning

confidence: 99%

“…Oliva et al in his review stated that out of 15 cases of isolated tuberculoma and tubercular liver abscess, 11 had positive reactions of tuberculin skin test whereas two patients were negative and two were anergic [14]. Guckian and Perry reported 41% patients were positive for tuberculin skin test [18]. …”

Section: Discussionmentioning

confidence: 99%

Tuberculosis as an Etiological Factor in Liver Abscess in Adults

Dey

Gautam

Venugopal

et al. 2016

Tuberculosis Research and Treatment

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Background. Tuberculosis of the liver without active pulmonary or miliary tuberculosis is considered as an uncommon diagnosis. The aim of the present study was to determine the etiological role of tuberculosis in adult patients presenting with features of liver abscess. Methods. A total of 40 patients with liver abscess were included in the study. The liver abscess aspirate was subjected to microscopy, culture, and polymerase chain reaction to determine the role of tuberculosis as an etiological factor in liver abscess. Results. Of the 40 patients enrolled, 25% (10/40) were diagnosed with having tubercular liver abscess. In a total of 40 specimens, 2.5% (1/40) were positive for acid fast bacilli by Ziehl-Neelsen method, while 10% (4/40) were positive for M. tuberculosis by culture using BACTEC 460 and the yield increased to 25% (10/40) by polymerase chain reaction for M. tuberculosis. Conclusion. 25% of the patients presenting with liver abscess had tubercular etiology without features of active pulmonary or miliary tuberculosis. Liver can act as the primary site of involvement in the absence of activity elsewhere in the body. Tuberculosis should be considered as an important differential diagnosis of liver abscess irrespective of evidence of active tuberculosis elsewhere in the body.

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“…Indeed, radioisotope scans of 17 Crohn patients re vealed half to have small spleens [9], al though splenic amyloid deposition may oc cur rarely with 2 cases out of 38 patients in one study [3]. However, splenic enlargement is frequent in sarcoid with up to 20% of patients having a palpable spleen [10] and half of 7 patients with hepatic involvement had splenomegaly [11], Thus the hepatic granulomas and splenomegaly favor the diagnosis of sarcoid not Crohn's disease. With granulomas in 3 sites, this case fulfills the criteria for sarcoidosis [2].…”

Section: Discussionmentioning

confidence: 99%