Granulomatous gastritis associated with Campylobacter pylori

Abstract

gastritis associated with Camp-vlobacrer pylori. APMIS 97:Three cases of granulomatous inflammation in gastric biopsies showing Campylobacter pylori infestation are described. This type of reaction to Campylobacterpylori has not previously been described, and occurred in I . 1% of gastric biopsies containing Campylobacter-like organisms (CLO), in this series of all gastric biopsies submitted for histological examination during one year. Two other cases each showed a mucosal granuloma: one was a patient with Crohn's disease and the other had foreign body giant cells in a biopsy of the edge of a healing gastric ulcer. Each of our three CLO-positive cases with granulomas showed scanty CLOs only. Thus, although granulomatous inflammation associated with CLOs is uncommon as a proportion of all CLO-positive gastric biopsies, these currently represent the commonest condition associated with granulomas in gastric biopsies, in our experience.

An unusual cause of granulomatous gastritis in an elderly patient: Helicobacter pylori

“…Hp infection of the gastric mucosa is frequently associated with nonspecific gastritis (5). Dhillon and Sawyerr first reported an association between granulomatous gastritis and Hp in 1989 (6). In our case, we showed the resolution of symptoms, endoscopic findings, and granulomatous gastritis after successful Hp eradication therapy.…”

Age-related differences in granulomatous gastritis: a retrospective, clinicopathological analysis

“…GG is an uncommon histological finding present in 0.08–0.35% of gastric biopsy samples,2 3 0.27% of biopsy samples from patients with gastritis,1 and 1.1% of samples from patients with H pylori gastritis 7. We conducted a retrospective study of 23 children and 23 adults with a final histological diagnosis of GG identified over a 7-year period to compare age-related differences in clinical and pathological features and to determine the prevalence of GG in a paediatric population.…”

“…Controversy persists with regard to the existence of ‘isolated’ or ‘idiopathic’ GG. One thought is that isolated GG is a well-described entity of unknown aetiology that may represent a non-specific reaction to a variety of unidentified agents 3 7. A competing thought is that isolated GG does not exist and that, with adequate long-term follow-up, an underlying aetiology could be determined 2…”

Abdominal Pain, Gastrointestinal Bleeding, and Weight Loss in a 17-Year-Old Male

“…Maeng et al [2] noted that 88.9% of the 18 cases they reviewed were positive for H. pylori, indicating a possible association of granulomatous gastritis with H. pylori. Dhillon and Sawyerr [3] were the first to report successful treatment of H. pylori-associated granulomatous gastritis with bismuth. Miyamoto et al [4] reported two cases of idiopathic granulomatous gastritis that resolved with H. pylori eradication.…”