Granulomatous dysimmune reactions (sarcoidosis, granuloma annulare, and others) on differently injured skin areas

Schiavo, Ada Lo; Ruocco, Eleonora; Gambardella, Alessio; O’Leary, Ryan; Gee, Sarah N.

doi:10.1016/j.clindermatol.2014.04.012

Cited by 34 publications

(32 citation statements)

References 73 publications

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“…SS represents approximately 6–14% of cutaneous sarcoidosis lesions in adults, but in one large series identifying 147 patients with cutaneous sarcoidosis lesions, SS was observed in 42 (28.6%) . The SS rate of 36.7% in our small series seems to be the highest rate hitherto reported.…”

Section: Demographic and Clinical Findings Of Patients With Sscontrasting

confidence: 49%

“…c,d). It is known that scars from accidental or surgical trauma are particularly susceptible to SS involvement but surgical scars may be preserved, as in our series, which needs further explanation …”

Section: Demographic and Clinical Findings Of Patients With Ssmentioning

confidence: 72%

“…Although infiltration of scars by noncaseating granulomas, i.e. scar sarcoidosis (SS), is a well‐known specific manifestation of cutaneous sarcoidosis, there are variable estimates of its frequency, and evaluation of the clinical features has been limited to small numbers of cases …”

Section: Demographic and Clinical Findings Of Patients With Ssmentioning

confidence: 99%

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Scar sarcoidosis: 11 patients with variable clinical features and invariable pulmonary involvement

et al. 2019

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Section: Demographic and Clinical Findings Of Patients With Sscontrasting

confidence: 49%

Section: Demographic and Clinical Findings Of Patients With Ssmentioning

confidence: 72%

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Scar sarcoidosis: 11 patients with variable clinical features and invariable pulmonary involvement

et al. 2019

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“…Recently, the term ‘Immunocompromised districts’ (ICD) has been proposed for a localized immune dysbalance in the skin after trauma. Interestingly, granulomatous skin diseases occur frequently in ICD predilection sites . As compared to the other patterns, level of evidence for a dominating role of a single lymphocyte subset is low for the granulomatous pattern.…”

Section: An Immunologic View At Inflammatory Skin Diseasesmentioning

confidence: 97%

Immune response patterns in non‐communicable inflammatory skin diseases

Eyerich

2018

Acad Dermatol Venereol

125

143

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Non‐communicable inflammatory skin diseases (ncISD) such as psoriasis or atopic eczema are a major cause of global disease burden. Due to their impact and complexity, ncISD represent a major challenge of modern medicine. Dermatology textbooks describe more than 100 different ncISD based on clinical phenotype and histological architecture. In the last decades, this historical description was complemented by increasing molecular knowledge – and this knowledge is now being translated into specific therapeutics. Combining the enormous advances made in lymphocyte immunology and molecular genetics with clinical and histological phenotyping reveals six immune response patterns of the skin – type I immune cells cause the lichenoid pattern characterized by immune‐mediated cell death of keratinocytes; type II immune cells underlie the eczematous pattern with impaired epidermal barrier, infection and eosinophils as well as the bullous pattern with loss of epithelial integrity; Th17 cells and ILC3 mediate the psoriatic pattern characterized by acanthosis, high metabolic activity and neutrophils; dysbalance of regulatory T cells causes either the fibrogenic pattern with rarefication of cells and dermal thickening or the granulomatous pattern defined by formation of granulomas. With more and more specific therapeutic agents approved, classifying ncISD also according to their immune response pattern will become highly relevant. This review defines the six immune response patterns of ncISD and highlights therapeutic strategies targeting key lymphocyte mediators.

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“…Conversely, another hypothesis is to consider granuloma in sarcoidosis as a host related inflammatory/immune reaction non‐specific of a special antigen or particulate occurring at sites where potential incidental triggering agents (scars, foreign material, antigens…) are already located. In line with this hypothesis is the observation of granuloma recurrence on tattoos or scars in parallel with exacerbation or relapse of systemic sarcoidosis …”

Section: Discussionmentioning

confidence: 77%

Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis

Colboc

Moguelet

Bazin

et al. 2018

Acad Dermatol Venereol

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This study emphasizes the need of using combined methods for assessment of mineral deposits in granulomatous diseases. According to the location and characteristics of deposits, we can hypothesize that SiO particles contribute to the granuloma formation, whereas CaCO deposits are related to the granuloma biology. However, the significance of the association between SiO deposits and sarcoidosis is still disputed.

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Granulomatous dysimmune reactions (sarcoidosis, granuloma annulare, and others) on differently injured skin areas

Cited by 34 publications

References 73 publications

Scar sarcoidosis: 11 patients with variable clinical features and invariable pulmonary involvement

Scar sarcoidosis: 11 patients with variable clinical features and invariable pulmonary involvement

Immune response patterns in non‐communicable inflammatory skin diseases

Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis

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