Granulomatous Choroiditis in Wegener Granulomatosis

Proia, Alan D.

doi:10.1001/archophthalmol.2011.62

Cited by 14 publications

(9 citation statements)

References 6 publications

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“…The Figure 5 The necrotizing granulomatous vasculitis in a patient with orbital GPA which was antineutrophil cytoplasmic antibody negative scleritis may be the only ocular manifestation or may occur in association with orbital disease and/or choroidal disease. Retinal and choroidal arteritis has been described but is also rare [47,48]. Keratitis has also been noted and is usually a peripheral ulcerative keratitis.…”

Section: Ocular Disease In Antineutrophil Cytoplasmic Antibodyassociamentioning

confidence: 99%

Ocular manifestations of systemic disease

Schmidt

Pulido

Matteson

2011

Current Opinion in Ophthalmology

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Section: Ocular Disease In Antineutrophil Cytoplasmic Antibodyassociamentioning

confidence: 99%

Ocular manifestations of systemic disease

Schmidt

Pulido

Matteson

2011

Current Opinion in Ophthalmology

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“…Like in dogs, human NS shows a rapidly extending, painful, and vision-threatening behavior [ 18 ]. They represent about 25% of human scleritis [ 7 , 8 ] and often occur in systemic autoimmune disease like granulomatosis with polyangiitis (GPA) [ 7 , 8 , 18 ], rheumatoid arthritis, systemic lupus erythematosus… However some GPA variants have been reported more recently in patients who presented only ocular lesions (e.g., dacryoadenitis, scleritis, episcleritis, orbitopathy or panuveitis) [ 9 , 11 , 23 , 25 , 26 , 27 ]. In this report, we decided to compare NS in our dog to NS observed in GPA.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Anti-Myeloperoxidase Antibodies in a Dog with Bilateral Necrotizing Scleritis

Cazalot

Lavergne

2015

Veterinary Sciences

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Necrotizing scleritis is uncommon in dogs and presumed to be immune-mediated. Its clinical pattern and histopathology are similar to ocular lesions observed in humans suffering from granulomatosis with polyangiitis (GPA), formerly named Wegener’s granulomatosis, where the pathogenesis revolves around anti-neutrophil antibodies (e.g., anti-myeloperoxidase). These antibodies are used to diagnose and follow-up the disease in humans, but variants that only affect the eyes often test negative. Here, we present the first case of canine necrotizing scleritis where measurement of anti-myeloperoxidase antibodies was attempted. A 1.5 year-old female Scottish Terrier was presented with bilateral deep multifocal scleromalacia, severe inflammation of corneal/uveal/retrobulbar tissues, perilimbal corneal oedema and neovascularization, hypotony, and mild exophthalmos. Corticosteroids and antibiotics had been administrated (topically and orally) without success. Due to painful multifocal scleral perforation with vitreal haemorrhage, the left eye underwent enucleation, so did the right eye one week later. The histopathology of the left eye revealed a neutrophilic and histiocytic scleral infiltration with extension of pyogranulomatous inflammation to the cornea, choroid, ciliary body, and orbital fat. Levels of plasma anti-myeloperoxidase antibodies were not statistically significant to those of 13 healthy dogs. Further research is warranted to investigate the presence and role of anti-neutrophil antibodies in canine necrotizing scleritis.

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“…On the other hand, retinal artery occlusion is usually associated with vasculitis [30]. Retinal and choroid manifestations that can be recognized in GPA are retinitis, chorioretinitis, macular edema, exudative retinal detachment, and retinal necrosis [4, 31–33]. Sclerochoroidal granulomas may also appear as uveal melanoma [4].…”

Section: Ocular Manifestations Of Granulomatosis With Polyangiitismentioning

confidence: 99%

Ocular Manifestations of Granulomatosis with Polyangiitis: A Review of the Literature

et al. 2019

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Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease of unknown etiology that is characterized by granulomatous inflammation, tissue necrosis, and vasculitis in small- and medium-sized vessels. Ocular and orbital manifestations are common in almost half of patients with GPA, affecting every structure of the eye, from the eyelid and orbit to the retina, the choroid, and the optic nerve, with a wide range of severity. Since imaging findings are not always specific for the diagnosis of GPA, biopsy is useful to confirm the diagnosis. Regarding treatment, a localized pharmaceutical and surgical approach may be helpful to achieve remission, while immunosuppressive therapy, corticosteroids, and cyclosporine are also useful. In any case, multidisciplinary intervention is required to reduce the rates of relapse and morbidity in patients with GPA.

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Granulomatous Choroiditis in Wegener Granulomatosis

Cited by 14 publications

References 6 publications

Ocular manifestations of systemic disease

Ocular manifestations of systemic disease

Investigation of Anti-Myeloperoxidase Antibodies in a Dog with Bilateral Necrotizing Scleritis

Ocular Manifestations of Granulomatosis with Polyangiitis: A Review of the Literature

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