Granulomatous appendicitis in a 12-year-old boy

Yayla, Derya; Alpman, Bedriye Nuray; Dölek, Yasemin

doi:10.1016/j.jpedsurg.2010.06.017

Cited by 15 publications

(9 citation statements)

References 17 publications

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“…The differential diagnosis of Crohn's disease at the early stages of the disease is difficult, since the disease localizes only on the appendix. Therefore, additional gastroenterological tests and a careful clinical follow-up are necessary following the pathological assessment [18][19][20]. Crohn's disease is a chronic disorder that presents itself with transmural inflammation in which there is epithelioid granulation in the intestinal wall.…”

Section: Discussionmentioning

confidence: 99%

Unusual Histopathological Findings in Childhood Appendectomy Specimens

et al. 2013

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The purpose of this study was to find the unusual findings in the childhood appendectomy specimens and their incidence. The clinicopathological data of 1,306 patients whose ages ranged from 3 to 16 were retrospectively collected. Histopathological findings in appendectomy specimens taken from patients who had a prediagnosis of appendicitis were obtained. Incidental appendectomies were not included in the research. Unusual findings were reevaluated in the histopathological assessment of appendectomy specimens. The number of patients whose pathological findings are considered unusual is 25 (1.91 %). Nine of the patients were girls and 16 of them were boys. Their ages ranged from 6 to 15. Pathological results revealed that there were 16 (1.22 %) cases of parasitosis, 3 (0.23 %) cases of granulomatosis, 3 (0.23 %) cases of eosinophilic appendicitis, 2 (0.15 %) cases of carcinoid tumors, and 1 (0.08 %) case of appendiceal non-Hodgkin's lymphoma. All patients underwent a standard appendectomy. Uncommon histopathological findings in childhood appendectomy specimens are more common than those in adulthood. This kind of certain unexpected lesions of the appendix may require advanced diagnostics, careful clinical care, follow-up for years, and a multidisciplinary approach. Therefore, histopathological examinations of appendectomy specimens must be performed routinely.

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Section: Discussionmentioning

confidence: 99%

Unusual Histopathological Findings in Childhood Appendectomy Specimens

et al. 2013

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“…[10] Since then, more than two hundred articles related to GAp have been published in the literature. [11] GAp is a rare entity, and it has been detected in approximately 0.1-2% of all appendectomy specimens obtained from patients with AAp. [4,6,7,11] While the incidence of GAp in western countries ranges from 0.14 % to 0.30%, the incidence in developing countries ranges from 1.3% to 2.3%.…”

Section: Discussionmentioning

confidence: 99%

“…[11] GAp is a rare entity, and it has been detected in approximately 0.1-2% of all appendectomy specimens obtained from patients with AAp. [4,6,7,11] While the incidence of GAp in western countries ranges from 0.14 % to 0.30%, the incidence in developing countries ranges from 1.3% to 2.3%. [6,11] In our study, when all appendectomy specimens that obtained from patients underwent a presumed diagnosis of AAp were considered, the prevalence of GAp was 0.59%.…”

Section: Discussionmentioning

confidence: 99%

“…[4,6,7,11] While the incidence of GAp in western countries ranges from 0.14 % to 0.30%, the incidence in developing countries ranges from 1.3% to 2.3%. [6,11] In our study, when all appendectomy specimens that obtained from patients underwent a presumed diagnosis of AAp were considered, the prevalence of GAp was 0.59%. However, the actual prevalence of GAp was calculated as 0.75% based on histopathological proven AAp cases, which was consistent with the literature.…”

Section: Discussionmentioning

confidence: 99%

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Differential Diagnosis of the Granulomatous Appendicitis: Retrospective Analysis of Sixteen Cases

Akbulut

Koç

Sarıcı

et al. 2020

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:This study aims to present the usability of real-time polymerase chain reaction (PCR) and interferon-gamma release assay (IGRA) in the differential diagnosis of granulomatous appendicitis (GAp), especially in areas where tuberculosis (TB) is endemic. METHODS:Sixteen patients underwent appendectomy with presumed diagnosis of acute appendicitis were retrospectively analyzed for histopathological diagnosis of GAp. Real-time PCR method was used to show the whether presence of DNA of the tubercle bacilli in paraffin-embedded tissue blocks. IGRA test was used to investigate whether tubercle bacilli-specific interferon gamma was present in peripheral blood. RESULTS:Sixteen patients (male: 10 female: 6) aged between 21 and 82 years were included in this study. All patients had acute appendicitis and three of them also had appendiceal perforation. Histopathologically, necrotizing granulomatous inflammation was detected in all appendectomy specimens. Acid-fast bacilli were not detected in any of the pathology slides stained with Ehrlich-Ziehl-Neelsen . Real-time PCR was studied in paraffin-embedded tissue blocks of all patients with GAp, but the TB bacilli DNA was amplified in only three patients. IGRA test was studied in peripheral blood samples of 12 patients with GAp and results were as follows: negative (n=9), positive (n=2) and indeterminate (n=1). CONCLUSION:We believe that the use of anamnesis, histopathological findings, tissue PCR, blood IGRA and clinical findings together are important for differential diagnosis of GAp, especially where TB is endemic. We also suggest that all appendectomy specimens should be sent to the laboratory for histopathological evaluation even if specimens appear macroscopically normal.

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“…Few case series in adult population have reported the incidence of GA between 0.14% and 2% of appendectomies. [1][2][3] There are only anecdotal case reports [4,5] with no real cohort study of GA in children hitherto; clearly mentioning the incidence, or specific characteristics. We made an attempt to determine the incidence and characteristics of the cases of GA operated in children at a single tertiary care institution.…”

Section: Introductionmentioning

confidence: 99%

Granulomatous appendicitis in children: A single institutional experience

Pal¹

2014

Afr J Paediatr Surg

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GA in children is a rare entity, with incidence of 1.04% and male preponderance in our series. Idiopathic causes were the most common followed by Yersinia enterocolitis and CD. Although majority remained asymptomatic, IBD should be ruled out in case of recurrence of pain or alteration of bowel habit. Therefore, a long-term follow-up (at least for 5 years) of idiopathic GA is suggested in children.

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Granulomatous appendicitis in a 12-year-old boy

Cited by 15 publications

References 17 publications

Unusual Histopathological Findings in Childhood Appendectomy Specimens

Unusual Histopathological Findings in Childhood Appendectomy Specimens

Differential Diagnosis of the Granulomatous Appendicitis: Retrospective Analysis of Sixteen Cases

Granulomatous appendicitis in children: A single institutional experience

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