Granulomatosis with polyangiitis: A case report and brief review of literature

Abstract

Granulomatosis with polyangiitis formerly known as Wegener's granulomatosis was first described by German pathologist Friedrich Wegener in 1936. It is a multi-system necrotizing noncaseating granulomatous vasculitis which affects small to medium-sized vessels. It can involve any organ system, most commonly the lungs and kidneys. American College of Rheumatology requires 2 of 4 criteria for diagnosis: Positive biopsy for granulomatous vasculitis, urinary sediment with red blood cells, abnormal chest radiograph and oral/nasal inflammation. Here we present a case of Granulomatosis with polyangiitis with brief review of literature.

Granulomatosis with polyangiitis with salivary glands involvement: presenting a case and describing its clinical, pathophysiological, and therapeutic aspects

“…Wegener granulomatosis or GPA is one of the rare components of a wide spectrum of diseases named ANCAassociated vasculitides. This disease was first described by Heinz Klinger and colleagues in 1931 those five years later; Friedrich Wegener described a series of affected patients and introduced it as a distinct form of vasculitis (7). From an etiological point of view, the exact etiologies of GPA remain unknown, however, the relationship between the pathophysiological changes of the disease and ANCA has been fully confirmed.…”

Granulomatosis with polyangiitis with salivary glands involvement: Presenting a case and describing its clinical, pathophysiological, and therapeutic aspects

“…Wegener granulomatosis or GPA is one of the rare components of a wide spectrum of diseases named ANCA‐associated vasculitides. This disease was first described by Heinz Klinger and colleagues in 1931 those 5 years later; Friedrich Wegener described a series of affected patients and introduced it as a distinct form of vasculitis 7 . From an etiological point of view, the exact etiologies of GPA remain unknown; however, the relationship between the pathophysiological changes of the disease and ANCA has been fully confirmed.…”

Acute ischemic optic neuropathy in a case of heroin overdose

“…Arteritic AION has female predisposition, whereas no gender discrepancy is noted in nonarteritic AION. Arteritic AION requires management of underlying vasculitis [14] , [15] , [16] . Nonarteritic AION encompasses majority (94.7%) of AION cases, with an estimated annual incidence of 2.3–10.2 per 100,000 population [ 9 , 17 , 18 ].…”