Granulomatosis linfomatoide con presentación neurológica. A propósito de un caso y revisión de la literatura

Gimeno, Javier; Alameda, Francesc; Garcı́a, M.; Bellosillo, Beatríz; Juanpere, Núria; Lopez, Laura; Murillo, Raquel; Munné, Jessica; Comerma, Laura; Padrón, Andreina; Torné, Ariadna; Baró, Teresa; Serrano, Sergio

doi:10.1016/j.patol.2009.12.001

Cited by 1 publication

(3 citation statements)

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“…LG is a lymphoproliferative disorder, in which tumorous B cells transform after infection with the Epstein-Barr virus. [ 4 ] This disease has a mortality rate of 60–90% and cerebral involvement occurs in 30% of cases. Primary CNS involvement is rare, being higher in men (2:1) with or without immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

“…LG can be graded based on the relative amount of tumor reactive cells and accompanying tumor cells. [ 4 14 ] When there is a predominance of small lymphocytes without cytological atypia, less than five Epstein-Barr virus (EBV) infected cells, and no necrosis, the condition may be said to be Grade 1. Grade 2 is characterized by a variable number of lymphoid cells transformed by EBV (5–20) and some necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Because of its angiocentric and angiodestructive character, LG can debut with intraparenchymal hemorrhage, stroke, or aneurysms. [ 4 22 ] Cerebral angiography may reveal changes consistent with vasculitis. [ 22 ]…”

Section: Discussionmentioning

confidence: 99%

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Lymphomatoid granulomatosis of the brain: A case report

et al. 2016

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Background:Lymphomatoid granulomatosis is a rare disorder of the central nervous system (CNS) with few cases being reported in literature. We present the case of an adult with an unusual lesion of the CNS who presented with motor seizures and was diagnosed with lymphomatoid granulomatosis, followed by a discussion of the process of evaluation and management.Case Description:A 42-year-old male presented with motor seizures and loss of consciousness for 10 minutes along with dysarthria and left hemiplegia. Neurological examination and imaging with magnetic resonance imaging (MRI) of the brain revealed a mass in the right striatum. The patient was hospitalized and underwent an image-guided right frontal craniotomy using the Leksell Stereotactic G-Frame. Pathology reported a lymphomatoid granulomatosis. Being immunocompetent, the patient received medical treatment with prednisone and rituximab. Two years after his diagnosis, the patient had no active disease and his brain MRI did not show contrast enhancement. After almost 3 years of follow-up, the patient has a mild weakness in the left-side of his body (4/5), is seizure-free, and can walk and perform daily activities.Conclusions:This rare lesion in an adult, immunocompetent patient, debuting with motor seizures represents a challenge in terms of diagnosis and treatment. After surgical and medical treatment, the patient had a satisfactory recovery. Clinical features, imaging, differential diagnosis, and pathology are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%