Granulomatosis anogenitales

Idiopathic granulomatous vulvitis and subsequent oral granulomatosis: a diagnostic and therapeutic challenge

“…Granulomatous vulvitis (GV) and anogenital granulomatosis (AGG) are descriptive terms for a rare inflammatory, chronic, relapsing erythema, oedema and ulcerations in the genitoperineal area, which lead to progressive distortion with permanent swelling and lymphoedema . AGG describes conditions, both infectious (e.g.…”

“…tuberculosis, sexually transmitted diseases or deep mycoses) and noninfectious, sharing clinical and histopathological features . Among the noninfectious granulomatous conditions, it is essential to consider metastatic (extraintestinal) Crohn disease (CD), sarcoidosis, foreign body granulomas and hidradenitis suppurativa . GV/AGG can affect people of all ages, while metastatic CD seems more frequent in women in the second to fourth decades of life .…”

“…Among the noninfectious granulomatous conditions, it is essential to consider metastatic (extraintestinal) Crohn disease (CD), sarcoidosis, foreign body granulomas and hidradenitis suppurativa . GV/AGG can affect people of all ages, while metastatic CD seems more frequent in women in the second to fourth decades of life . Treatment of both conditions is challenging, with options including corticosteroids, antibiotics and immunosuppressants (azathioprine and ciclosporin) .…”

“…GV/AGG can affect people of all ages, while metastatic CD seems more frequent in women in the second to fourth decades of life . Treatment of both conditions is challenging, with options including corticosteroids, antibiotics and immunosuppressants (azathioprine and ciclosporin) . Drugs based on monoclonal antibodies targeting antitumour necrosis factor‐α are newer promising options …”