Granulomatose de Wegener du sujet âgé

Fauchais, A.L.; Michon-Pasturel, U.; Rugale, C.; Asseray, Nathalie; Bulckaen, H.; Queyrel, V.; Puisieux, François; Hebbar, Mohamed; Hachulla, É.; Hatron, Pierre‐Yves; Devulder, B

doi:10.1016/s0248-8663(00)00302-7

Cited by 11 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Son diagnostic repose sur des arguments cliniques, biologiques et histologiques. La GPA reste une maladie rare, survenant en général chez des patients âgés de 40 à 50 ans [ 5 ] et se voit rarement chez le sujet âgé comme en témoigne la rareté des séries gériatriques publiées [ 6 , 7 ]. Le diagnostic est souvent porté plus tardivement dans cette tranche d’âge, les différentes séries de la littérature retrouvent en effet un délai diagnostique moyen de cinq à 13 mois après le début des premiers symptômes [ 4 , 6 ].…”

Section: Discussionunclassified

“…Différents travaux font état d'une prévalence accrue de l'atteinte rénale de la GPA chez les sujets âgés [ 4 , 6 , 13 ], l'atteinte rénale était en effet présente chez notre deuxième patiente et découverte lors d'un bilan rénal de dépistage dans le cadre de sa maladie, elle était absente dans le premier cas. Dans une série gériatrique publiée par Fauchais et al [ 7 ] incluant 11 patients âgés de plus de 60 ans et suivis pour GPA, l'atteinte ORL était observée dans 91% des cas et l'atteinte pulmonaire était aussi fréquente touchant 82% des cas. Les atteintes ORL et pulmonaire étaient en effet constantes dans nos deux observations.…”

Section: Discussionunclassified

See 1 more Smart Citation

Granulomatose avec polyangéite du sujet âgé: à propos de deux cas et revue de la littérature

Berriche¹,

Hammami

Ammari³

et al. 2015

Pan Afr Med J

View full text Add to dashboard Cite

show abstract

Section: Discussionunclassified

Granulomatose avec polyangéite du sujet âgé: à propos de deux cas et revue de la littérature

Berriche¹,

Hammami

Ammari³

et al. 2015

Pan Afr Med J

View full text Add to dashboard Cite

show abstract

Predicting mortality in systemic Wegener's granulomatosis: A survival analysis based on 93 patients

Bligny¹,

Mahr²,

Toumelin³

et al. 2004

Arthritis & Rheumatism

141

View full text Add to dashboard Cite

Objective. To determine predictors of survival of patients with systemic Wegener's granulomatosis (WG).Methods. We retrospectively studied 93 patients (median age 52 years, male/female ratio 1.7) with systemic WG. All subjects received cytotoxic drugs. Survival was evaluated as a function of the main clinical and laboratory parameters and 2 disease activity scores assessed at diagnosis. Statistical analyses used the multivariate Cox proportional hazards regression model. Results. The mean followup was 4.5 years; 25 (27%) patients died. According to univariate analysis, a pejorative prognostic value was attributed to serum creatinine >160 mole/liter (P < 0.001); age >52 years (P < 0.002); absence of ear, nose, and throat (ENT) involvement (P < 0.001); and hemoglobin <11.8 gm/dl (P ‫؍‬ 0.02). Multivariate analysis retained age >52 years (hazard ratio [HR] ‫؍‬ 3.40, P ‫؍‬ 0.04) as an independent predictor of poor outcome, whereas the presence of ENT involvement was associated with a longer survival (HR ‫؍‬ 0.31, P ‫؍‬ 0.02). Conclusion. Our results suggest that an older age and the absence of ENT involvement at diagnosis independently predict an increased risk of mortality for WG patients. These findings could indicate that the prognosis of WG might be governed by the balance between the granulomatosis as opposed to the vasculitic disease process.

show abstract

Wegener’s granulomatosis: experience from a Brazilian tertiary center

et al. 2010

View full text Add to dashboard Cite

Most epidemiological studies with Wegener's granulomatosis (WG) patients are based on populations from the Northern hemisphere, whereas very few studies have been conducted in Southern hemisphere populations, particularly from South America. The authors performed a large retrospective, demographic study including clinical and laboratory profiles of 134 consecutive WG patients seen at one Brazilian center from 1999 to 2009. Mean age at initial WG diagnosis was 43.4 +/- 15.5 years, and mean disease duration was 8.6 +/- 6.6 years. Sixty-four (47.8%) patients were male and a total of 113 (84.3%) subjects were white. Ear/nose/throat involvement occurred in 85.8%. The classic lung and renal involvement were observed in 77.6% and 75.4%, respectively, followed by ocular (35.8%), musculoskeletal (33.4%), cutaneous (29.1%), neurological (20.1%), cardiac (11.2%), and genitourinary involvement in 2.2% of cases. Cytoplasmic pattern-antineutrophil cytoplasmic antibody was detected in 83 (61.9%) cases. Ten (7.5%) individuals presented limited forms of WG. Classic therapy with corticosteroids and cyclophosphamide was used in 97 cases (72.4%). There were no cases of tuberculosis or Pneumocystis jiroveci pneumonia, but cutaneous herpes zoster occurred in eight (6.0%) individuals. There were 29 deaths (21.6%). Eighteen patients died of septic shock (mainly bacterial pneumonia), whereas four died of alveolar hemorrhage, four of myocardial infarction, and three of other causes. In summary, our data from a very large retrospective and descriptive study mirrored the main clinical features of WG described in other countries, demonstrating that they may serve as a reference for South American populations.

show abstract

Granulomatose de Wegener du sujet âgé

Cited by 11 publications

References 7 publications

Granulomatose avec polyangéite du sujet âgé: à propos de deux cas et revue de la littérature

Granulomatose avec polyangéite du sujet âgé: à propos de deux cas et revue de la littérature

Predicting mortality in systemic Wegener's granulomatosis: A survival analysis based on 93 patients

Wegener’s granulomatosis: experience from a Brazilian tertiary center

Contact Info

Product

Resources

About