Granulomas in Dermatopathology: Principal Diagnoses — Part 2

Aguilar, J. Aróstegui; Diago, A.; Gijón, R. Carrillo; Figueras, M. Fernández; Fraga, Javier; Herrera, A. García; Garrido, María C.; Gastearena, Miguel Ángel Idoate; Laga, Alvaro C.; Llamas‐Velasco, M.; Campayo, N. Martínez; Monteagudo, Carlos; Onrubia, Jorge; Muñoz, N. Pérez; Ríos‐Martín, J.J.; Ríos‐Viñuela, E.; Peralto, J.L. Rodríguez; Muñoz, E. Rozas; Sanmartín, O.; Santonja, Carlos; Santos‐Briz, Ángel; Saus, Carlos; Peñaranda, José Manuel Suárez; Benito, V. Velasco; Merino, María J.; Fernández-Flores, Ángel

doi:10.1016/j.adengl.2021.07.010

Cited by 2 publications

(1 citation statement)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasma proteins coating the surface of any foreign material may have integrin receptors that allow macrophages to bind 34,35 . When phagocytosis fails (“frustrated phagocytosis”), macrophages join to form foreign body giant cells (FBGCs) pathognomonic with a foreign body response (FBR) 36,37 . FBGC continue to attempt to destroy the foreign material by secreting enzymes and reactive oxygen species 38 …”

Section: Dermal Wound Healingmentioning

confidence: 99%

Introducing aesthetic regenerative scaffolds: An immunological perspective

Corduff¹

2023

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background Skin aging arises from immunological responses to tissue deterioration and damage. Tissue repair processes encompass the regeneration of original tissue and ‘scarless’ wound healing seen in foetuses, and the extreme fibrotic responses and scarring seen in adults. Anti‐aging aesthetic medicine uses interventions like biomaterial‐based fillers to influence these immunological responses and renew aged tissue structure and function. At filler injection sites, an inflammatory response occurs that causes a spectrum of outcomes, ranging from tissue regeneration to fibrosis and filler encapsulation. Importantly, the resulting inflammatory pathway can be predetermined by the biomaterial injected. Aims By understanding this immunological process, we can develop Aesthetic Regenerative Scaffolds (ARS) ‐ aesthetic injectable biomaterials ‐ to direct inflammatory wound healing away from chronic, fibrotic responses, and towards physiological tissue regeneration. Materials and Methods We identified and reviewed literature on the immunological and cellular responses to injected dermal fillers, whereby the wound healing response to the injection was moderated under the influence of an injected biomaterial. Results We described the mechanisms of dermal wound healing and the use of ARS to direct healing towards tissue regeneration instead of scarring. We also summarised studies on extracellular matrix remodeling by calcium hydroxylapatite. We found that Calcium hydroxylapatite fillers produce collagen as they gradually degrade and their spherical structures serve as a scaffold for tissue regeneration. Furthermore, CaHA improved fibroblast contractility, collagen type III and elastin production, proliferation and angiogenesis with less inflammation than hyaluronic acid fillers. Discussion Regneration pathways can be influenced at specific points between a facial filler biomaterial and the wound healingmechanisms at its site of implantaion. Conclusion Physicians can select scaffolds that direct the immune response away from a fibrotic chronic inflammatory pathway and towards regeneration to enable true repair of the aging skin.

show abstract

Section: Dermal Wound Healingmentioning

confidence: 99%

Introducing aesthetic regenerative scaffolds: An immunological perspective

Corduff¹

2023

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

Oral Granulomatous Disorders: A Diagnostic Insight

Roychowdhury,

Chatterjee,

Gayen

et al. 2024

Cureus

View full text Add to dashboard Cite

Granulomatous inflammation represents a unique pattern of chronic inflammation observed in a restricted form of infectious and certain non-infectious diseases. The formation of granulomas typically involves immune responses. Granulomatous disorders encompass a broad spectrum of conditions that share the common histological feature of granuloma formation. Their involvement in the oral soft and hard tissues is quite infrequent; however, their manifestation can pose a diagnostic challenge due to the diverse range of potential causes and the relatively non-specific appearance of the individual lesions. The ultimate outcome of a complex entails the formation of a granuloma, resulting from the interplay among an invading pathogen or antigen, chemical substance, medication, or other irritant, persistent presence of antigens in the bloodstream, activation of macrophages, initiation of Th1 cell response, B-cell overactivity, presence of circulating immune complexes, and a wide range of biological signaling molecules, ultimately leading to the development of fibrosis attributed to the actions of transforming and platelet-derived growth factor. This article emphasizes the clinicopathological diagnostic criteria of oral granulomatous disorders as a guide for treatment and management.

show abstract

Granulomas in Dermatopathology: Principal Diagnoses — Part 2

Cited by 2 publications

References 57 publications

Introducing aesthetic regenerative scaffolds: An immunological perspective

Introducing aesthetic regenerative scaffolds: An immunological perspective

Oral Granulomatous Disorders: A Diagnostic Insight

Contact Info

Product

Resources

About